U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C10H15NO.ClH
Molecular Weight 201.693
Optical Activity ( + )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Pseudoephedrine hydrochloride

SMILES

Cl.CN[C@@H](C)[C@@H](O)C1=CC=CC=C1

InChI

InChIKey=BALXUFOVQVENIU-KXNXZCPBSA-N
InChI=1S/C10H15NO.ClH/c1-8(11-2)10(12)9-6-4-3-5-7-9;/h3-8,10-12H,1-2H3;1H/t8-,10+;/m0./s1

HIDE SMILES / InChI
Molecular Formula C10H15NO
Molecular Weight 165.2322
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/12373557 | http://www.mayoclinic.org/drugs-supplements/ephedra--ma-huang/background/hrb-20059270 | https://www.sudafed.com/adult-products/congestion/sudafed-24-hour#uses-and-directions | https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0011888 | https://www.ncbi.nlm.nih.gov/pubmed/11772135 | https://www.ncbi.nlm.nih.gov/pubmed/10449190 | https://www.ncbi.nlm.nih.gov/pubmed/12954796

Pseudoephedrine is a sympathomimetic drug. Pseudoephedrine acts as an adrenomimetic and inhibitor of monoamine transporters. Ephedra sinica, a species of ephedra (ma huang), contains ephedrine and pseudoephedrine. Ephedra has been found to stimulate the nervous system, increase airflow into the lungs and constrict blood vessels. In combination with caffeine, ephedra appears to cause weight loss. Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Pseudoephedrine is used to relieve nasal or sinus congestion caused by the common cold, sinusitis, and hay fever and other respiratory allergies.

CNS Activity

Originator

Ladenburg, A.
4
Sources: A. Ladenburg, C. Oelschlägel, Ber. 22, 1823 (1889).
Curator's Comment: (+)-threo-isomer of ephedrine, q.v. Isoln from E. vulgaris: A. Ladenburg, C. Oelschlägel, Ber. 22, 1823 (1889). Synthesis: E. Späth, R. Göhring, Monatsh. Chem. 41, 319 (1920). reference retrieved from http://www.drugfuture.com/chemdata/pseudoephedrine.html

Approval Year

1961
146
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
 5.6 µM [IC50]
Inhibitor
8297
 1.18 µM [IC50]
Agonist
2678
Agonist
2678
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
SUDAFED 24 HOUR

Approved Use

temporarily relieves nasal congestion due to the common cold, hay fever or other upper respiratory allergies; reduces swelling of nasal passages; relieves sinus pressure

Launch Date

1992
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
292 ng/mL
OTHER GOV
https://www.accessdata.fda.gov/drugsatfda_docs/nda/pre96/073585Orig1s000.pdf
120 mg single, oral
dose: 120 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PSEUDOEPHEDRINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
4346 ng × h/mL
OTHER GOV
https://www.accessdata.fda.gov/drugsatfda_docs/nda/pre96/073585Orig1s000.pdf
120 mg single, oral
dose: 120 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PSEUDOEPHEDRINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
6.3 h
OTHER GOV
https://www.accessdata.fda.gov/drugsatfda_docs/nda/pre96/073585Orig1s000.pdf
120 mg single, oral
dose: 120 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PSEUDOEPHEDRINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
1500 mg single, oral
Overdose
Dose: 1500 mg
Route: oral
Route: single
Dose: 1500 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/19006543
unknown, 16 years
n = 1
Health Status: unknown
Age Group: 16 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/19006543
Other AEs: Rhabdomyolysis, Creatine kinase increased...
Other AEs:
Rhabdomyolysis (1 patient)
Creatine kinase increased (1 patient)
Blood myoglobin increased (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/19006543
150 mg 2 times / day multiple, oral
Highest studied dose
Dose: 150 mg, 2 times / day
Route: oral
Route: multiple
Dose: 150 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
healthy, 24 years
n = 17
Health Status: healthy
Age Group: 24 years
Sex: M
Population Size: 17
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
Other AEs: Tension, Dry mouth...
Other AEs:
Tension (10 patients)
Dry mouth (6 patients)
Tachycardia (9 patients)
Palpitations (10 patients)
Anxiety (13 patients)
Insomnia (12 patients)
Anorexia (7 patients)
Restlessness (10 patients)
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
90 mg 1 times / day multiple, oral
Overdose
Dose: 90 mg, 1 times / day
Route: oral
Route: multiple
Dose: 90 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/18365604
unhealthy, 3 years
n = 1
Health Status: unhealthy
Age Group: 3 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/18365604
Disc. AE: Urinary retention...
AEs leading to
discontinuation/dose reduction:
Urinary retention (acute, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/18365604
30 mg 2 times / day multiple, oral
Dose: 30 mg, 2 times / day
Route: oral
Route: multiple
Dose: 30 mg, 2 times / day
Co-administed with::
acetominophen(500 mg twice daily, oral)
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
unhealthy, 37 years
n = 1
Health Status: unhealthy
Condition: sinusitis
Age Group: 37 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
Disc. AE: Ischemic colitis, Abdominal pain...
AEs leading to
discontinuation/dose reduction:
Ischemic colitis (1 patient)
Abdominal pain (acute, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
720 mg 1 times / day multiple, oral
Highest studied dose
Dose: 720 mg, 1 times / day
Route: oral
Route: multiple
Dose: 720 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/23918202
unhealthy, 38.8 years
n = 38
Health Status: unhealthy
Age Group: 38.8 years
Sex: M+F
Population Size: 38
Sources:
https://pubmed.ncbi.nlm.nih.gov/23918202
Sources:
https://pubmed.ncbi.nlm.nih.gov/23918202
30 mg 3 times / day multiple, oral
Dose: 30 mg, 3 times / day
Route: oral
Route: multiple
Dose: 30 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
unhealthy, 44 years
n = 1
Health Status: unhealthy
Condition: upper airway infection
Age Group: 44 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
Disc. AE: Ischemic colitis, Abdominal pain...
AEs leading to
discontinuation/dose reduction:
Ischemic colitis (1 patient)
Abdominal pain (acute, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
120 mg 1 times / day multiple, oral
Dose: 120 mg, 1 times / day
Route: oral
Route: multiple
Dose: 120 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
unhealthy, 46 years
n = 1
Health Status: unhealthy
Condition: chronic sinusitis | allergic rhinitis
Age Group: 46 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
Disc. AE: Ischemic colitis, Abdominal pain...
AEs leading to
discontinuation/dose reduction:
Ischemic colitis (1 patient)
Abdominal pain (acute, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
30 mg 2 times / day multiple, oral
Dose: 30 mg, 2 times / day
Route: oral
Route: multiple
Dose: 30 mg, 2 times / day
Co-administed with::
acetominophen(500 mg twice daily, oral)
chlorpheniramine maleate(2 mg; twice daily, oral)
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
unhealthy, 50 years
n = 1
Health Status: unhealthy
Condition: rhinitis
Age Group: 50 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
Disc. AE: Ischemic colitis, Abdominal pain...
AEs leading to
discontinuation/dose reduction:
Ischemic colitis (1 patient)
Abdominal pain (acute, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
720 mg single, oral
Overdose
Dose: 720 mg
Route: oral
Route: single
Dose: 720 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/18608273
unhealthy, 87 years
n = 1
Health Status: unhealthy
Age Group: 87 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/18608273
Other AEs: Hypertension...
Other AEs:
Hypertension (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/18608273
AEs

AEs

AESignificanceDosePopulation
Blood myoglobin increased 1 patient
1500 mg single, oral
Overdose
Dose: 1500 mg
Route: oral
Route: single
Dose: 1500 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/19006543
unknown, 16 years
n = 1
Health Status: unknown
Age Group: 16 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/19006543
Creatine kinase increased 1 patient
1500 mg single, oral
Overdose
Dose: 1500 mg
Route: oral
Route: single
Dose: 1500 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/19006543
unknown, 16 years
n = 1
Health Status: unknown
Age Group: 16 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/19006543
Rhabdomyolysis 1 patient
1500 mg single, oral
Overdose
Dose: 1500 mg
Route: oral
Route: single
Dose: 1500 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/19006543
unknown, 16 years
n = 1
Health Status: unknown
Age Group: 16 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/19006543
Palpitations 10 patients
150 mg 2 times / day multiple, oral
Highest studied dose
Dose: 150 mg, 2 times / day
Route: oral
Route: multiple
Dose: 150 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
healthy, 24 years
n = 17
Health Status: healthy
Age Group: 24 years
Sex: M
Population Size: 17
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
Restlessness 10 patients
150 mg 2 times / day multiple, oral
Highest studied dose
Dose: 150 mg, 2 times / day
Route: oral
Route: multiple
Dose: 150 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
healthy, 24 years
n = 17
Health Status: healthy
Age Group: 24 years
Sex: M
Population Size: 17
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
Tension 10 patients
150 mg 2 times / day multiple, oral
Highest studied dose
Dose: 150 mg, 2 times / day
Route: oral
Route: multiple
Dose: 150 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
healthy, 24 years
n = 17
Health Status: healthy
Age Group: 24 years
Sex: M
Population Size: 17
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
Insomnia 12 patients
150 mg 2 times / day multiple, oral
Highest studied dose
Dose: 150 mg, 2 times / day
Route: oral
Route: multiple
Dose: 150 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
healthy, 24 years
n = 17
Health Status: healthy
Age Group: 24 years
Sex: M
Population Size: 17
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
Anxiety 13 patients
150 mg 2 times / day multiple, oral
Highest studied dose
Dose: 150 mg, 2 times / day
Route: oral
Route: multiple
Dose: 150 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
healthy, 24 years
n = 17
Health Status: healthy
Age Group: 24 years
Sex: M
Population Size: 17
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
Dry mouth 6 patients
150 mg 2 times / day multiple, oral
Highest studied dose
Dose: 150 mg, 2 times / day
Route: oral
Route: multiple
Dose: 150 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
healthy, 24 years
n = 17
Health Status: healthy
Age Group: 24 years
Sex: M
Population Size: 17
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
Anorexia 7 patients
150 mg 2 times / day multiple, oral
Highest studied dose
Dose: 150 mg, 2 times / day
Route: oral
Route: multiple
Dose: 150 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
healthy, 24 years
n = 17
Health Status: healthy
Age Group: 24 years
Sex: M
Population Size: 17
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
Tachycardia 9 patients
150 mg 2 times / day multiple, oral
Highest studied dose
Dose: 150 mg, 2 times / day
Route: oral
Route: multiple
Dose: 150 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
healthy, 24 years
n = 17
Health Status: healthy
Age Group: 24 years
Sex: M
Population Size: 17
Sources:
https://pubmed.ncbi.nlm.nih.gov/729619
Urinary retention acute, 1 patient
Disc. AE
90 mg 1 times / day multiple, oral
Overdose
Dose: 90 mg, 1 times / day
Route: oral
Route: multiple
Dose: 90 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/18365604
unhealthy, 3 years
n = 1
Health Status: unhealthy
Age Group: 3 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/18365604
Ischemic colitis 1 patient
Disc. AE
30 mg 2 times / day multiple, oral
Dose: 30 mg, 2 times / day
Route: oral
Route: multiple
Dose: 30 mg, 2 times / day
Co-administed with::
acetominophen(500 mg twice daily, oral)
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
unhealthy, 37 years
n = 1
Health Status: unhealthy
Condition: sinusitis
Age Group: 37 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
Abdominal pain acute, 1 patient
Disc. AE
30 mg 2 times / day multiple, oral
Dose: 30 mg, 2 times / day
Route: oral
Route: multiple
Dose: 30 mg, 2 times / day
Co-administed with::
acetominophen(500 mg twice daily, oral)
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
unhealthy, 37 years
n = 1
Health Status: unhealthy
Condition: sinusitis
Age Group: 37 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
Ischemic colitis 1 patient
Disc. AE
30 mg 3 times / day multiple, oral
Dose: 30 mg, 3 times / day
Route: oral
Route: multiple
Dose: 30 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
unhealthy, 44 years
n = 1
Health Status: unhealthy
Condition: upper airway infection
Age Group: 44 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
Abdominal pain acute, 1 patient
Disc. AE
30 mg 3 times / day multiple, oral
Dose: 30 mg, 3 times / day
Route: oral
Route: multiple
Dose: 30 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
unhealthy, 44 years
n = 1
Health Status: unhealthy
Condition: upper airway infection
Age Group: 44 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
Ischemic colitis 1 patient
Disc. AE
120 mg 1 times / day multiple, oral
Dose: 120 mg, 1 times / day
Route: oral
Route: multiple
Dose: 120 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
unhealthy, 46 years
n = 1
Health Status: unhealthy
Condition: chronic sinusitis | allergic rhinitis
Age Group: 46 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
Abdominal pain acute, 1 patient
Disc. AE
120 mg 1 times / day multiple, oral
Dose: 120 mg, 1 times / day
Route: oral
Route: multiple
Dose: 120 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
unhealthy, 46 years
n = 1
Health Status: unhealthy
Condition: chronic sinusitis | allergic rhinitis
Age Group: 46 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
Ischemic colitis 1 patient
Disc. AE
30 mg 2 times / day multiple, oral
Dose: 30 mg, 2 times / day
Route: oral
Route: multiple
Dose: 30 mg, 2 times / day
Co-administed with::
acetominophen(500 mg twice daily, oral)
chlorpheniramine maleate(2 mg; twice daily, oral)
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
unhealthy, 50 years
n = 1
Health Status: unhealthy
Condition: rhinitis
Age Group: 50 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
Abdominal pain acute, 1 patient
Disc. AE
30 mg 2 times / day multiple, oral
Dose: 30 mg, 2 times / day
Route: oral
Route: multiple
Dose: 30 mg, 2 times / day
Co-administed with::
acetominophen(500 mg twice daily, oral)
chlorpheniramine maleate(2 mg; twice daily, oral)
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
unhealthy, 50 years
n = 1
Health Status: unhealthy
Condition: rhinitis
Age Group: 50 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/10484004
Hypertension 1 patient
720 mg single, oral
Overdose
Dose: 720 mg
Route: oral
Route: single
Dose: 720 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/18608273
unhealthy, 87 years
n = 1
Health Status: unhealthy
Age Group: 87 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/18608273
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:51209
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:51209
ZINC
ZINC000000020259
http://zinc15.docking.org/substances/ZINC000000020259
eMolecules
494893
https://www.emolecules.com/cgi-bin/more?vid=494893
PubMed

PubMed

TitleDatePubMed
A Double-blind crossover trial of pseudoephedrine and triprolidine, alone and in combination, for the treatment of allergenic rhinitis.
1975 Jan
Dextromethorphan- and pseudoephedrine-induced agitated psychosis and ataxia: case report.
1999 Mar-Apr
Cetirizine/pseudoephedrine.
2001
Clinical prescribing of allergic rhinitis medication in the preschool and young school-age child: what are the options?
2001
Recurrent ischaemic colitis associated with pseudoephedrine use.
2001 Apr
Chromatographic analysis of phenethylamine-antihistamine combinations using C8, C18 or cyano columns and micellar sodium dodecyl sulfate-pentanol mixtures.
2001 Apr
A fast and efficient determination of amines and preservatives in cough and cold liquid and suspension formulations using a single isocratic ion-pairing high performance [correction of power] liquid chromatography method.
2001 Aug
Aziridine ring-opening reactions with chiral enolates. Stereocontrolled synthesis of 5-substituted-3-methyl-pyrrolidin-2-ones.
2001 Aug 24
Effect of organic cations on the renal tubular secretion of pseudoephedrine in the rat.
2001 Jan-Feb
Cold-syrup induced movement disorder.
2001 Jun
Stability indicating HPTLC method for the simultaneous determination of pseudoephedrine and cetirizine in pharmaceutical formulations.
2001 Jun
Asymmetric synthesis of beta-substituted alpha-methyl-beta-amino esters by Mannich reaction of (S,S)-(+)-pseudoephedrine acetamide derived enolate with imines.
2001 Mar 8
Factitious hypertension by pseudoephedrine.
2001 Mar-Apr
Acute myocardial ischemia associated with ingestion of bupropion and pseudoephedrine in a 21-year-old man.
2001 May
Linezolid: pharmacokinetic and pharmacodynamic evaluation of coadministration with pseudoephedrine HCl, phenylpropanolamine HCl, and dextromethorpan HBr.
2001 May
Cardiovascular sympathomimetic amine interactions in rats treated with monoamine oxidase inhibitors and the novel oxazolidinone antibiotic linezolid.
2001 May
Epinephrine analogues.
2001 Nov
[Separation and determination of pseudoephedrine in bufferin cold tablet by capillary electrophoresis with hydropropyl-beta-cyclodextrin as chiral selective reagent].
2001 Nov
Biotransformation of benzaldehyde into (R)-phenylacetylcarbinol by filamentous fungi or their extracts.
2001 Oct
Separation and determination of ephedrine alkaloids and tetramethylpyrazine in Ephedra sinica Stapf by gas chromatography-mass spectrometry.
2001 Sep
Rapid chiral on-chip separation with simplified amperometric detection.
2001 Sep 14
Analysis of enantiomers giving partially overlapped peaks by using different treatments of the chromatographic ultraviolet signals: quantification of pseudoephedrine enantiomers.
2001 Sep 28
Linezolid: its role in the treatment of gram-positive, drug-resistant bacterial infections.
2002 Feb 15
Pseudoephedrine causing mania-like symptoms.
2002 Feb 22
Maternal medication use and risks of gastroschisis and small intestinal atresia.
2002 Jan 1
Modifying the bitterness of selected oral pharmaceuticals with cation and anion series of salts.
2002 Jul
Pharmacology of ephedra alkaloids and caffeine after single-dose dietary supplement use.
2002 Jun
Implementation of the Comprehensive Methamphetamine Control Act of 1996; regulation of pseudoephedrine, phenylpropanolamine, and combination ephedrine drug products and reports of certain transactions to nonregulated persons. Final rule.
2002 Mar 28
Pigmented purpuric dermatosis due to pseudoephedrine.
2002 May
[Blood supply of the lips].
2002 Oct
Stereospecific inhibition of monoamine uptake transporters by meta-hydroxyephedrine isomers.
2002 Oct
Efficacy of once-daily desloratadine/pseudoephedrine for relief of nasal congestion.
2002 Sep-Oct
Pharmacokinetic interaction study of a fixed combination of 500 mg acetylsalicylic acid/30 mg pseudoephedrine versus each of the single active ingredients in healthy male volunteers.
2003
[Improving the medical treatment of minors who are victims of sexual assault or physical abuse: a receiving center and partnership between a psychiatric hospital and university hospital].
2003 Apr
Surfing, self-medicating and safety: buying non-prescription and complementary medicines via the internet.
2003 Apr
Nonpigmenting solitary fixed drug eruption caused by a Chinese traditional herbal medicine, ma huang (Ephedra Hebra), mainly containing pseudoephedrine and ephedrine.
2003 Apr
Controlled porosity osmotic pump-based controlled release systems of pseudoephedrine. I. Cellulose acetate as a semipermeable membrane.
2003 Apr 14
Efficacy and safety of clemastine-pseudoephedrine-acetaminophen versus pseudoephedrine-acetaminophen in the treatment of seasonal allergic rhinitis in a 1-day, placebo-controlled park study.
2003 Jan
Safety of selegiline with cold medications.
2003 Mar
In vitro evaluation of apical microleakage following canal filling with a coated carrier system compared with lateral and thermomechanical Gutta-Percha condensation techniques.
2003 May
A comparative study of root canal preparation using FlexMaster and HERO 642 rotary Ni-Ti instruments.
2003 May
Canine model of nasal congestion and allergic rhinitis.
2003 May
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Sample Use Guides

In Vivo Use Guide
SUDAFED® 24 HOUR TABLET, EXTENDED RELEASE; ORAL (PSEUDOEPHEDRINE HYDROCHLORIDE) 240MG adults and children 12 years and older: a tablet with water every 24 hours children under 12 years: do not use this product in children under 12 years of age
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: Pseudoephedrine inhibits interleukin-2 (IL-2) and tumor necrosis factor (TNF) alpha-gene transcription in stimulated Jurkat cells, a human T-cell leukemia cell line.
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 19:06:44 GMT 2023
Edited
by admin
on Sat Dec 16 19:06:44 GMT 2023
Record UNII
6V9V2RYJ8N
Record Status Validated (UNII)
Record Version
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Name Type Language
Pseudoephedrine hydrochloride
EP   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
USAN  
Official Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ALLEGRA-D
Common Name English
ACTAHIST COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
CODIMAL-L.A. 12 COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
BROMANATE DM COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
ALLERFED COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
RHINALAIR
Brand Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF HISTAFED
Common Name English
SINE-AID IB COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ALEVE-D
Common Name English
TRIACIN-C COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
TRIPHED COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
MYFED COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE [EP MONOGRAPH]
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF CODIMAL-L.A. 12
Common Name English
HISTAFED COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF CHILDREN'S ADVIL COLD
Common Name English
ALLEGRA-D COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE [ORANGE BOOK]
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ACTIFED
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF SINE-AID IB
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF BROMANATE DM
Common Name English
TRILITRON COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ADVIL ALLERGY SINUS
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE [MART.]
Common Name English
CORPHED COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF TRIPHED
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ZYRTEC-D
Common Name English
GALSUD
Brand Name English
DIMETANE-DX COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF TRILITRON
Common Name English
SEMPREX-D COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
CHILDREN'S ADVIL COLD COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
SUDAFED
Brand Name English
PSEUDOEPHEDRINE HYDROCHLORIDE [USP-RS]
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE [MI]
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE [USAN]
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF MYFED
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF BROMFED-DM
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF DIMETANE-DX
Common Name English
HYCOFENIX COMPONENT OF PSEUDOEPHEDRINE HYDROCHLORIDE
Brand Name English
OTRINOL
Brand Name English
ZYRTEC-D COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
NSC-33634
Code English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF TRIACIN-C
Common Name English
BROMFED-DM COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
Pseudoephedrine hydrochloride [WHO-DD]
Common Name English
CHILDREN'S MOTRIN COLD COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ALLERFED
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF MUCINEX D
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE [VANDF]
Common Name English
EFIDAC 24
Brand Name English
PSEUDOEPHEDRINE HYDROCHLORIDE [USP MONOGRAPH]
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF CHILDREN'S MOTRIN COLD
Common Name English
PSEUDOEPHEDRINE HCL
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ISOCLOR
Common Name English
MUCINEX D COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF SEMPREX-D
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ACTAHIST
Common Name English
ADVIL ALLERGY SINUS COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
ALEVE-D COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
ACTIFED COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF HYCOFENIX
Brand Name English
GALPSEUD
Brand Name English
ISOCLOR COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Common Name English
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF CORPHED
Common Name English
NSC-106567
Code English
Classification Tree Code System Code
NCI_THESAURUS C29709
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
CFR 21 CFR 341.20
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
DEA NO. 8112
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
Code System Code Type Description
NSC
106567
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY
DAILYMED
6V9V2RYJ8N
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY
SMS_ID
100000092030
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY
EVMPD
SUB04119MIG
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY
RS_ITEM_NUM
1581005
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY
NCI_THESAURUS
C29390
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY
ChEMBL
CHEMBL1590
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY
EPA CompTox
DTXSID10889343
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY
CAS
345-78-8
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY
RXCUI
91168
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY RxNorm
NSC
33634
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY
ECHA (EC/EINECS)
206-462-1
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY
DRUG BANK
DBSALT000149
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY
PUBCHEM
9581
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY
FDA UNII
6V9V2RYJ8N
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY
MERCK INDEX
m9294
Created by admin on Sat Dec 16 19:06:44 GMT 2023 , Edited by admin on Sat Dec 16 19:06:44 GMT 2023
PRIMARY Merck Index
Related Record Type Details
Structure of Pseudoephedrine hydrochloride
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
Term
Structure of PSEUDOEPHEDRINE
PARENT -> SALT/SOLVATE
Structure of Pseudoephedrine hydrochloride
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
Structure of PSEUDOEPHEDRINE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of Pseudoephedrine hydrochloride
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of PSEUDOEPHEDRINE
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
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HHS VULNERABILITY DISCLOSURE
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