DROCINONIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H35FO6
Molecular Weight	438.5295
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CC[C@H]5CC(=O)CC[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO

InChI

InChIKey=GZBONOYGBJSTHF-QLRNAMTQSA-N

InChI=1S/C24H35FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h13,15-17,19,26,28H,5-12H2,1-4H3/t13-,15-,16-,17-,19+,21-,22-,23-,24+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C24H35FO6
Molecular Weight	438.5295
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	9 / 9
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/508182 | https://www.ncbi.nlm.nih.gov/pubmed/1185572 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 471, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Drocinonide is a synthetic glucocorticoid used as anti-inflammatory agent. It was shown that drocinonide phosphate potassium is effective ocular anti-inflammatory agent that does not show a strong tendency to elevate the intra-ocular pressure. Drocinonide phosphate potassium forms an insoluble complex with neomycin sulfate in aqueous solution. Dibasic sodium phosphate can be employed in an ophthalmic formulation to prevent the formation of this precipitate without affecting the stability of the steroid or the bioactivity of the antibiotic.

Approval Year

PubMed

Title	Date	PubMed
Intraocular pressure response to topically administered fluorometholone.	1979-11	508182
Stabilizing effect of inorganic phosphate salts on antibiotic-steroid ophthalmic preparations.	1975-09	1185572

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:49:51 GMT 2025` Edited by `admin` on `Wed Apr 02 09:49:51 GMT 2025`
Record UNII	6UJ1P9T59P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DROCINONIDE

Official Name

English

9-Fluoro-11?,16?,17,21-tetrahydroxy-5?-pregnane-3,20-dione cyclic 16,17-acetal with acetone

Preferred Name

English

TETRAHYDROTRIAMCINOLONE ACETONIDE

Common Name

English

DROCINONIDE [USAN]

Common Name

English

PREGNANE-3,20-DIONE, 9-FLUORO-11,21-DIHYDROXY-16,17-((1-METHYLETHYLIDENE)BIS(OXY))-, (5.ALPHA.,11.BETA.,16.ALPHA.)-

Common Name

English

drocinonide [INN]

Common Name

English

Code System Code Type Description

WIKIPEDIA

Drocinonide