Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H19FN4O4S |
| Molecular Weight | 430.453 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=C2N=CC=CC2=C(N=C1C(=O)NCC3=CC=C(F)C=C3)N4CCCCS4(=O)=O
InChI
InChIKey=DIDKWCOCQJWMDJ-UHFFFAOYSA-N
InChI=1S/C20H19FN4O4S/c21-14-7-5-13(6-8-14)12-23-20(27)17-18(26)16-15(4-3-9-22-16)19(24-17)25-10-1-2-11-30(25,28)29/h3-9,26H,1-2,10-12H2,(H,23,27)
| Molecular Formula | C20H19FN4O4S |
| Molecular Weight | 430.453 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Dihydroxythiophenes are novel potent inhibitors of human immunodeficiency virus integrase with a diketo acid-like pharmacophore. | 2006 Jul |
|
| A potent and orally active HIV-1 integrase inhibitor. | 2007 Mar 1 |
|
| Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). | 2008 Jan |
|
| Primary mutations selected in vitro with raltegravir confer large fold changes in susceptibility to first-generation integrase inhibitors, but minor fold changes to inhibitors with second-generation resistance profiles. | 2010 Jul 5 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:16:53 GMT 2023
by
admin
on
Sat Dec 16 08:16:53 GMT 2023
|
| Record UNII |
6TXL33ZFOP
|
| Record Status |
Validated (UNII)
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| Record Version |
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6TXL33ZFOP
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410544-95-5
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457930
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admin on Sat Dec 16 08:16:53 GMT 2023 , Edited by admin on Sat Dec 16 08:16:53 GMT 2023
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