Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H19FN4O4S |
| Molecular Weight | 430.453 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=C(N=C(N2CCCCS2(=O)=O)C3=CC=CN=C13)C(=O)NCC4=CC=C(F)C=C4
InChI
InChIKey=DIDKWCOCQJWMDJ-UHFFFAOYSA-N
InChI=1S/C20H19FN4O4S/c21-14-7-5-13(6-8-14)12-23-20(27)17-18(26)16-15(4-3-9-22-16)19(24-17)25-10-1-2-11-30(25,28)29/h3-9,26H,1-2,10-12H2,(H,23,27)
| Molecular Formula | C20H19FN4O4S |
| Molecular Weight | 430.453 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Comparative antiviral activity of integrase inhibitors in human monocyte-derived macrophages and lymphocytes. | 2011-11 |
|
| Primary mutations selected in vitro with raltegravir confer large fold changes in susceptibility to first-generation integrase inhibitors, but minor fold changes to inhibitors with second-generation resistance profiles. | 2010-07-05 |
|
| The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore. | 2009-03-15 |
|
| Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase. | 2009-03 |
|
| Potent inhibitors of HIV-1 integrase display a two-step, slow-binding inhibition mechanism which is absent in a drug-resistant T66I/M154I mutant. | 2009-02-24 |
|
| Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors. | 2008-08 |
|
| Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents. | 2008-04-24 |
|
| Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). | 2008-01 |
|
| Mirabamides A-D, depsipeptides from the sponge Siliquariaspongia mirabilis that inhibit HIV-1 fusion. | 2007-11 |
|
| New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors. | 2007-06 |
|
| A potent and orally active HIV-1 integrase inhibitor. | 2007-03-01 |
|
| Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors. | 2006-08-01 |
|
| Dihydroxythiophenes are novel potent inhibitors of human immunodeficiency virus integrase with a diketo acid-like pharmacophore. | 2006-07 |
|
| Novel HIV-1 integrase inhibitors derived from quinolone antibiotics. | 2006-03-09 |
|
| Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors. | 2005-11-03 |
|
| A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase. | 2004-08-03 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:58:55 GMT 2025
by
admin
on
Mon Mar 31 21:58:55 GMT 2025
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| Record UNII |
6TXL33ZFOP
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| Record Status |
Validated (UNII)
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| Record Version |
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