U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C15H22N2O2
Molecular Weight 262.3474
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DABELOTINE

SMILES

CN1CCCC2=C1C(OCC3CNCCO3)=CC=C2

InChI

InChIKey=VXQWMLATWQSCBE-UHFFFAOYSA-N
InChI=1S/C15H22N2O2/c1-17-8-3-5-12-4-2-6-14(15(12)17)19-11-13-10-16-7-9-18-13/h2,4,6,13,16H,3,5,7-11H2,1H3

HIDE SMILES / InChI

Molecular Formula C15H22N2O2
Molecular Weight 262.3474
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Dabelotine is a cognitive-enhancing drug, developed by Servier. The drug has been shown to improve some aspects of cognitive processes, such as attention, curiosity, motivation, acquisition, and recall of memory. Dabelotine has also been shown to reduce the effect of an anticholinergic drug such as scopolamine. The drug increases the in vitro K+-induced norepinephrine release in rodent cerebral slices, and have no effect on noradrenergic and cholinergic receptor binding sites. Dabelotine was investigated in phase 2 clinical trials for the treatment of dementia, where it was demonstrated that 50-mg and 100-mg doses produced an improvement in reaction time and performance in memory tasks.

Approval Year

Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 15:54:27 GMT 2023
Edited
by admin
on Sat Dec 16 15:54:27 GMT 2023
Record UNII
6RY56RB98P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DABELOTINE
INN  
INN  
Official Name English
QUINOLINE, 1,2,3,4-TETRAHYDRO-1-METHYL-8-(2-MORPHOLINYLMETHOXY)-, (±)-
Systematic Name English
(±)-1,2,3,4-TETRAHYDRO-1-METHYL-8-(2-MORPHOLINYLMETHOXY)QUINOLINE
Systematic Name English
QUINOLINE, 1,2,3,4-TETRAHYDRO-1-METHYL-8-(2-MORPHOLINYLMETHOXY)-
Systematic Name English
dabelotine [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29747
Created by admin on Sat Dec 16 15:54:27 GMT 2023 , Edited by admin on Sat Dec 16 15:54:27 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C74103
Created by admin on Sat Dec 16 15:54:27 GMT 2023 , Edited by admin on Sat Dec 16 15:54:27 GMT 2023
PRIMARY
EVMPD
SUB06881MIG
Created by admin on Sat Dec 16 15:54:27 GMT 2023 , Edited by admin on Sat Dec 16 15:54:27 GMT 2023
PRIMARY
FDA UNII
6RY56RB98P
Created by admin on Sat Dec 16 15:54:27 GMT 2023 , Edited by admin on Sat Dec 16 15:54:27 GMT 2023
PRIMARY
CAS
118976-38-8
Created by admin on Sat Dec 16 15:54:27 GMT 2023 , Edited by admin on Sat Dec 16 15:54:27 GMT 2023
PRIMARY
SMS_ID
100000083971
Created by admin on Sat Dec 16 15:54:27 GMT 2023 , Edited by admin on Sat Dec 16 15:54:27 GMT 2023
PRIMARY
ChEMBL
CHEMBL2106098
Created by admin on Sat Dec 16 15:54:27 GMT 2023 , Edited by admin on Sat Dec 16 15:54:27 GMT 2023
PRIMARY
PUBCHEM
177949
Created by admin on Sat Dec 16 15:54:27 GMT 2023 , Edited by admin on Sat Dec 16 15:54:27 GMT 2023
PRIMARY
EPA CompTox
DTXSID70869621
Created by admin on Sat Dec 16 15:54:27 GMT 2023 , Edited by admin on Sat Dec 16 15:54:27 GMT 2023
PRIMARY
INN
7289
Created by admin on Sat Dec 16 15:54:27 GMT 2023 , Edited by admin on Sat Dec 16 15:54:27 GMT 2023
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE
Related Record Type Details
ACTIVE MOIETY