Mitopodozide (“Proresid') is a cytotoxic drug, also of natural origin, being derived from the root of an American plant of the podophyllum family. Proresid has also been used as a disease-modifying antirheumatic drug since the late 1960s. Proresid is a microtubulin antagonist comparable to colchicine and griseofulvin. It has antimitotic and granulocytechemotaxis-inhibiting properties. Proresid has been used with good results as a disease-modifying drug (DMD) in the treatment of Rheumatoid Arthritis (RA). A high frequency of gastrointestinal side effects, mostly diarrhoea is reported. Initially, Proresid was used as an anticancer agent, but it was later discovered that his anti-tumor effect is limited in comparison with other cytostatics, and its use for this purpose has therefore been discontinued. Later it was discovered that Proresid may be used in the treatment of rheumatoid arthritis and rare cases of secondary amyloidosis. However, the gastrointestinal tract side effects have made it impossible to use Proresid in doses high enough to provide really useful therapeutic effect.