Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C17H23N5O2S |
| Molecular Weight | 361.462 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC1=NC2=C(N)N=C3C=CC=CC3=C2N1CCCCNS(C)(=O)=O
InChI
InChIKey=YZOQZEXYFLXNKA-UHFFFAOYSA-N
InChI=1S/C17H23N5O2S/c1-3-14-21-15-16(12-8-4-5-9-13(12)20-17(15)18)22(14)11-7-6-10-19-25(2,23)24/h4-5,8-9,19H,3,6-7,10-11H2,1-2H3,(H2,18,20)
| Molecular Formula | C17H23N5O2S |
| Molecular Weight | 361.462 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
CPG-52852 (PF-04878691) is a toll-like receptor 7 (TRL7) agonist. The drug was developed by 3M Pharmaceuticals and the Coley Pharmaceutical Group and was investigated in a number of clinical trials in patients with advanced cancer. Sustained tolerability and modest clinical benefit were demonstrated in heavily pretreated recurrent breast, ovarian, and cervix cancers. After Coley was acquired by Pfizer in 2007, the drug was repurposed for the treatment of hepatitis C. A phase 1 clinical trial was conducted. The development of the compound was discontinued because the compound was believed to unlikely to achieve the proof-of-concept criteria as a result of pharmacodynamic modeling.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:38:17 UTC 2023
by
admin
on
Fri Dec 15 15:38:17 UTC 2023
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| Record UNII |
6PJC3KPK6S
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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Common Name | English | ||
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Systematic Name | English | ||
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Code | English | ||
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Code | English |
| Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
218105
Created by
admin on Fri Dec 15 15:38:18 UTC 2023 , Edited by admin on Fri Dec 15 15:38:18 UTC 2023
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FDA ORPHAN DRUG |
176603
Created by
admin on Fri Dec 15 15:38:18 UTC 2023 , Edited by admin on Fri Dec 15 15:38:18 UTC 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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6PJC3KPK6S
Created by
admin on Fri Dec 15 15:38:18 UTC 2023 , Edited by admin on Fri Dec 15 15:38:18 UTC 2023
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C61104
Created by
admin on Fri Dec 15 15:38:18 UTC 2023 , Edited by admin on Fri Dec 15 15:38:18 UTC 2023
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532959-63-0
Created by
admin on Fri Dec 15 15:38:17 UTC 2023 , Edited by admin on Fri Dec 15 15:38:17 UTC 2023
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300000042572
Created by
admin on Fri Dec 15 15:38:18 UTC 2023 , Edited by admin on Fri Dec 15 15:38:18 UTC 2023
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10309114
Created by
admin on Fri Dec 15 15:38:18 UTC 2023 , Edited by admin on Fri Dec 15 15:38:18 UTC 2023
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DTXSID20201416
Created by
admin on Fri Dec 15 15:38:18 UTC 2023 , Edited by admin on Fri Dec 15 15:38:18 UTC 2023
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DB12476
Created by
admin on Fri Dec 15 15:38:18 UTC 2023 , Edited by admin on Fri Dec 15 15:38:18 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
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TARGET -> AGONIST |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |
