CPG-52852

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H23N5O2S
Molecular Weight	361.462
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1=NC2=C(N)N=C3C=CC=CC3=C2N1CCCCNS(C)(=O)=O

InChI

InChIKey=YZOQZEXYFLXNKA-UHFFFAOYSA-N

InChI=1S/C17H23N5O2S/c1-3-14-21-15-16(12-8-4-5-9-13(12)20-17(15)18)22(14)11-7-6-10-19-25(2,23)24/h4-5,8-9,19H,3,6-7,10-11H2,1-2H3,(H2,18,20)

HIDE SMILES / InChI

Molecular Formula	C17H23N5O2S
Molecular Weight	361.462
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18056192 | https://www.ncbi.nlm.nih.gov/pubmed/20820775 | https://www.ncbi.nlm.nih.gov/pubmed/21689140

CPG-52852 (PF-04878691) is a toll-like receptor 7 (TRL7) agonist. The drug was developed by 3M Pharmaceuticals and the Coley Pharmaceutical Group and was investigated in a number of clinical trials in patients with advanced cancer. Sustained tolerability and modest clinical benefit were demonstrated in heavily pretreated recurrent breast, ovarian, and cervix cancers. After Coley was acquired by Pfizer in 2007, the drug was repurposed for the treatment of hepatitis C. A phase 1 clinical trial was conducted. The development of the compound was discontinued because the compound was believed to unlikely to achieve the proof-of-concept criteria as a result of pharmacodynamic modeling.

Approval Year

PubMed

Title	Date	PubMed
Toll-like receptor-7 agonist administered subcutaneously in a prolonged dosing schedule in heavily pretreated recurrent breast, ovarian, and cervix cancers.	2010-12	20820775

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:03:52 GMT 2025` Edited by `admin` on `Mon Mar 31 18:03:52 GMT 2025`
Record UNII	6PJC3KPK6S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CPG-52852

Common Name

English

852A

Preferred Name

English

N-(4-(4-AMINO-2-ETHYL-IMIDAZO(4,5-C)QUINOLIN-1-YL)BUTYL)METHANESULFONAMIDE

Systematic Name

English

PF-4878691

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

218105