U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Wed Apr 02 19:21:35 GMT 2025
Edited
by admin
on Wed Apr 02 19:21:35 GMT 2025
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials State LIVE GENETICALLY MODIFIED
Source Materials Parent
Part BLOOD
Fraction Name CD4+/CD8+ enriched T cells
Record UNII
6NEK9A2UZ5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Liraltagene Autoleucel
INN  
Official Name English
autologous CD4+/CD8+ enriched T lymphocytes derived from leukapheresis material, transduced with a non-replicating murine stem cell virus (MSCV)-derived gamma retroviral vector, encoding codon-optimised follicle-stimulating hormone (FSH) (subunits FSH? a
Preferred Name English
liraltagene autoleucel [INN]
Common Name English
Code System Code Type Description
INN
13378
Created by admin on Wed Apr 02 19:21:35 GMT 2025 , Edited by admin on Wed Apr 02 19:21:35 GMT 2025
PRIMARY
FDA UNII
6NEK9A2UZ5
Created by admin on Wed Apr 02 19:21:35 GMT 2025 , Edited by admin on Wed Apr 02 19:21:35 GMT 2025
PRIMARY
Related Record Type Details
TARGET->CYTOTOXIC T-CELL
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
EXPANSION
ACTIVATOR
RETROVIRAL TRANSFECTION TRANSFECTION GENE MODIFICATION Liraltagene autoleucel vector EH2R77URG3

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN Liraltagene autoleucel expressed follicle stimulating hormone fusion protein PR73HQV9RS
INSERTED GENE EXPRESSION VECTOR Liraltagene autoleucel transgene insert U4HZC9CG3U
Name Property Type Amount Referenced Substance Defining Parameters References
ANTIGEN LOW EXPRESSION BIOLOGICAL
ANTIGEN EXPRESSED BIOLOGICAL
ANTIGEN NOT EXPRESSED BIOLOGICAL