Liraltagene Autoleucel

Investigational

Approval Year

Substance Class	Structurally Diverse
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Name	CD4+/CD8+ enriched T cells
Record UNII	6NEK9A2UZ5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Liraltagene Autoleucel

Official Name

English

autologous CD4+/CD8+ enriched T lymphocytes derived from leukapheresis material, transduced with a non-replicating murine stem cell virus (MSCV)-derived gamma retroviral vector, encoding codon-optimised follicle-stimulating hormone (FSH) (subunits FSH? a

Preferred Name

English

liraltagene autoleucel [INN]

Common Name

English

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Code System

Code

Type

Description

INN

13378

PRIMARY

FDA UNII

6NEK9A2UZ5

PRIMARY

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Related Record

Type

Details


					KB2P81D50D

FOLLICLE-STIMULATING HORMONE RECEPTOR

TARGET->CYTOTOXIC T-CELL

Amount:

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Related Record

Type

Details


					6NEK9A2UZ5

Liraltagene Autoleucel

ACTIVE MOIETY

Amount:

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Agent Modifications

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Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
	EXPANSION		expanded in growth media containing anti-CD3 and IL-2
	ACTIVATOR		activation with anti-CD3 and interleukin 2 (IL-2)
RETROVIRAL TRANSFECTION	TRANSFECTION	GENE MODIFICATION		Liraltagene autoleucel vector	EH2R77URG3

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					Liraltagene autoleucel expressed follicle stimulating hormone fusion protein	PR73HQV9RS
INSERTED GENE EXPRESSION VECTOR					Liraltagene autoleucel transgene insert	U4HZC9CG3U

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Name	Property Type	Amount	Referenced Substance
ANTIGEN LOW EXPRESSION	BIOLOGICAL	[<0.5] % (average)	`0X8U3V6C5K` MONOCYTE DIFFERENTIATION ANTIGEN CD14
ANTIGEN EXPRESSED	BIOLOGICAL	[>90] % (average)	`ZLW14X2D30` CD3
ANTIGEN NOT EXPRESSED	BIOLOGICAL	[<0.08] % (average)	`IYZ9TI08W3` B-LYMPHOCYTE ANTIGEN CD19

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