ZOLASARTAN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H20BrClN6O3
Molecular Weight	555.811
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC1=NC(Cl)=C(N1CC2=CC3=C(OC(=C3Br)C4=CC=CC=C4C5=NN=NN5)C=C2)C(O)=O

InChI

InChIKey=FIKYECRHLXONOX-UHFFFAOYSA-N

InChI=1S/C24H20BrClN6O3/c1-2-3-8-18-27-22(26)20(24(33)34)32(18)12-13-9-10-17-16(11-13)19(25)21(35-17)14-6-4-5-7-15(14)23-28-30-31-29-23/h4-7,9-11H,2-3,8,12H2,1H3,(H,33,34)(H,28,29,30,31)

HIDE SMILES / InChI

Molecular Formula	C24H20BrClN6O3
Molecular Weight	555.811
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8012689 | https://adisinsight.springer.com/drugs/800001788

Zolasartan (previously known as GR 117289) is an angiotensin II (AT1) receptor antagonist that was studied for the treatment of hypertension. It was undergoing phase II clinical trials with Glaxo Wellcome in the United Kingdom before the study was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Pharmacological profile of GR117289 in vitro: a novel, potent and specific non-peptide angiotensin AT1 receptor antagonist.	1992 Dec	1467838
Angiotensin II receptor antagonists: an emerging new class of cardiovascular therapeutics.	1999 Jul	10487332
Pharmacological properties of angiotensin II receptor antagonists.	1999 Nov	10579749

Sample Use Guides

In Vivo Use Guide

10 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:50:02 UTC 2023` Edited by `admin` on `Fri Dec 15 15:50:02 UTC 2023`
Record UNII	6NA6UHB9SW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZOLASARTAN

Official Name

English

GR 117289C

Code

English

GR117289

Code

English

GR-117289

Code

English

GR-117289X

Code

English

GR 117289X

Code

English

GR-117289C

Code

English

zolasartan [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66930