KOSN-1724

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H39NO6
Molecular Weight	473.6017
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H]1C=CCC(C)=CC[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)C(\C)=C\C2=NOC(C)=C2

InChI

InChIKey=JAYGOFBXDFAXBW-CYEKYUJNSA-N

InChI=1S/C27H39NO6/c1-16-9-8-10-17(2)25(31)20(5)26(32)27(6,7)23(29)15-24(30)33-22(12-11-16)18(3)13-21-14-19(4)34-28-21/h8,10-11,13-14,17,20,22-23,25,29,31H,9,12,15H2,1-7H3/b10-8-,16-11-,18-13+/t17-,20+,22-,23-,25-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C27H39NO6
Molecular Weight	473.6017
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://clinicaltrials.gov/ct2/show/NCT01379287 | https://www.cancer.gov/publications/dictionaries/cancer-drug/def/iso-fludelone

KOSN-1724, also known as iso-fludelone, is the third-generation epothilone B analogue. It binds to tubulin and induces microtubule polymerization/reduces microtubule depolymerization, resulting in the inhibition of cell division and induction of apoptosis. KOSN-1724 is in phase I clinical trials for the treatment of solid tumors.

Originator

Approval Year

PubMed

Title	Date	PubMed
Quantitative method for the determination of iso-fludelone (KOS-1803) in human plasma by LC-MS/MS.	2014-11	25168219
Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones.	2008-09-02	18755900

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:27:52 GMT 2025` Edited by `admin` on `Mon Mar 31 21:27:52 GMT 2025`
Record UNII	6MUO20693U
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ISO-FLUDELONE

Preferred Name

English

KOSN-1724

Common Name

English

OXACYCLOHEXADECA-10,13-DIENE-2,6-DIONE, 4,8-DIHYDROXY-5,5,7,9,13-PENTAMETHYL-16-((1E)-1-METHYL-2-(5-METHYL-3-ISOXAZOLYL)ETHENYL)-, (4S,7R,8S,9S,10E,13Z,16S)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2584