KOSN-1724

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H39NO6
Molecular Weight	473.6017
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H]1C=CCC(C)=CC[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)C(\C)=C\C2=NOC(C)=C2

InChI

InChIKey=JAYGOFBXDFAXBW-CYEKYUJNSA-N

InChI=1S/C27H39NO6/c1-16-9-8-10-17(2)25(31)20(5)26(32)27(6,7)23(29)15-24(30)33-22(12-11-16)18(3)13-21-14-19(4)34-28-21/h8,10-11,13-14,17,20,22-23,25,29,31H,9,12,15H2,1-7H3/b10-8-,16-11-,18-13+/t17-,20+,22-,23-,25-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C27H39NO6
Molecular Weight	473.6017
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://clinicaltrials.gov/ct2/show/NCT01379287 | https://www.cancer.gov/publications/dictionaries/cancer-drug/def/iso-fludelone

KOSN-1724, also known as iso-fludelone, is the third-generation epothilone B analogue. It binds to tubulin and induces microtubule polymerization/reduces microtubule depolymerization, resulting in the inhibition of cell division and induction of apoptosis. KOSN-1724 is in phase I clinical trials for the treatment of solid tumors.

Originator

Approval Year

PubMed

Title	Date	PubMed
Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones.	2008 Sep 2	18755900
Quantitative method for the determination of iso-fludelone (KOS-1803) in human plasma by LC-MS/MS.	2014 Nov	25168219

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:14:38 GMT 2023` Edited by `admin` on `Sat Dec 16 05:14:38 GMT 2023`
Record UNII	6MUO20693U
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

KOSN-1724

Common Name

English

OXACYCLOHEXADECA-10,13-DIENE-2,6-DIONE, 4,8-DIHYDROXY-5,5,7,9,13-PENTAMETHYL-16-((1E)-1-METHYL-2-(5-METHYL-3-ISOXAZOLYL)ETHENYL)-, (4S,7R,8S,9S,10E,13Z,16S)-

Systematic Name

English

ISO-FLUDELONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2584