Details
Stereochemistry | ACHIRAL |
Molecular Formula | C33H31ClF3NO3 |
Molecular Weight | 582.052 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CC1=CC=CC(OCCCN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CC4=CC=CC(=C4Cl)C(F)(F)F)=C1
InChI
InChIKey=NAXSRXHZFIBFMI-UHFFFAOYSA-N
InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40)
Molecular Formula | C33H31ClF3NO3 |
Molecular Weight | 582.052 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL4093 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22406419 |
5.0 nM [EC50] | ||
Target ID: CHEMBL2808 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22406419 |
22.0 nM [EC50] |
PubMed
Title | Date | PubMed |
---|---|---|
LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. | 2009 Nov |
|
The human ADFP gene is a direct liver-X-receptor (LXR) target gene and differentially regulated by synthetic LXR ligands. | 2010 Jan |
|
Stimulation of lipogenesis as well as fatty acid oxidation protects against palmitate-induced INS-1 beta-cell death. | 2011 Mar |
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Liver X receptor α bidirectionally transactivates human CYP1A1 and CYP1A2 through two cis-elements common to both genes. | 2012 Nov 23 |
|
Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator. | 2013 Aug 1 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:26:32 GMT 2023
by
admin
on
Sat Dec 16 08:26:32 GMT 2023
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Record UNII |
6JI5YOG7RC
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Record Status |
Validated (UNII)
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Record Version |
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6JI5YOG7RC
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DTXSID60961002
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405911-09-3
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DB03791
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