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Details

Stereochemistry ABSOLUTE
Molecular Formula C8H10BrNO3S
Molecular Weight 280.139
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BROBACTAM

SMILES

CC1(C)S[C@@H]2[C@H](Br)C(=O)N2[C@H]1C(O)=O

InChI

InChIKey=DAVPSCAAXXVSFU-ALEPSDHESA-N
InChI=1S/C8H10BrNO3S/c1-8(2)4(7(12)13)10-5(11)3(9)6(10)14-8/h3-4,6H,1-2H3,(H,12,13)/t3-,4+,6-/m1/s1

HIDE SMILES / InChI

Molecular Formula C8H10BrNO3S
Molecular Weight 280.139
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Brobactam is a synthetic inhibitor of beta-lactamases produced by both gram-positive and gram-negative bacteria. Brobactam potentiates the antibacterial activity of ampicillin against a wide range of clinically important bacterial strains which produce beta-lactamase. No resistant sub-population was observed amongst the strain s of staphylococci studied, and the development of resistance in vitro was not recorded in individual strains of Staphylococcus aureus and Escherichia coli exposed to subinhibitory concentrations of ampicillin/brobactam. Reduced sensitivity was observed in the case of one strain of M. morganii, which was known to produce an inducible chromosomal cephalosporinase.

Approval Year

PubMed

Patents

Substance Class Chemical
Record UNII
6I6JCF8EOE
Record Status Validated (UNII)
Record Version