GAROMEFRINE HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C9H13FN2O3S.ClH
Molecular Weight	284.735
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CS(=O)(=O)NC1=CC([C@@H](O)CN)=C(F)C=C1

InChI

InChIKey=NYBZUGIMUSJVGU-FVGYRXGTSA-N

InChI=1S/C9H13FN2O3S.ClH/c1-16(14,15)12-6-2-3-8(10)7(4-6)9(13)5-11;/h2-4,9,12-13H,5,11H2,1H3;1H/t9-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	C9H13FN2O3S
Molecular Weight	248.275
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8719417 | https://adisinsight.springer.com/drugs/800005693

Garomefrine (NS-49) is a partial agonist of 1a-adrenoreceptor, selective with respect to other alpha 1 adrenoreceptors. It was developed by Nippon Shinyaku and investigated in clinical trials for the treatment of urinary incontinence in Japan, Europe, and the USA.

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:31:29 GMT 2025` Edited by `admin` on `Mon Mar 31 18:31:29 GMT 2025`
Record UNII	6GS0T2F4ZR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GAROMEFRINE HYDROCHLORIDE

Common Name

English

ABT-232

Preferred Name

English

METHANESULFONAMIDE, N-(3-((1R)-2-AMINO-1-HYDROXYETHYL)-4-FLUOROPHENYL)-, MONOHYDROCHLORIDE

Common Name

English

GAROMEFRIN HYDROCHLORIDE, (-)-

Common Name

English

GAROMEFRIN MONOHYDROCHLORIDE

Common Name

English

(-)-GAROMEFRIN HYDROCHLORIDE

Common Name

English

PNO-49B

Common Name

English

METHANESULFONAMIDE, N-(3-(2-AMINO-1-HYDROXYETHYL)-4-FLUOROPHENYL)-, MONOHYDROCHLORIDE, (R)-

Common Name

English

((R)-(-)-3'-(2-AMINO-1-HYDROXYETHYL)-4'-FLUORO-METHANESULFONANILIDE HYDROCHLORIDE

Common Name

English

METHANESULFONAMIDE, N-(3-((1R)-2-AMINO-1-HYDROXYETHYL)-4-FLUOROPHENYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

GAROMEFRINE HYDROCHLORIDE [JAN]

Common Name

English

NS-49

Common Name

English

Code System Code Type Description

CHEBI

167680