Details
Stereochemistry | ABSOLUTE |
Molecular Formula | 2C18H20FN3O4.H2O |
Molecular Weight | 740.7503 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.C[C@H]1COC2=C3N1C=C(C(O)=O)C(=O)C3=CC(F)=C2N4CCN(C)CC4.C[C@H]5COC6=C7N5C=C(C(O)=O)C(=O)C7=CC(F)=C6N8CCN(C)CC8
InChI
InChIKey=SUIQUYDRLGGZOL-RCWTXCDDSA-N
InChI=1S/2C18H20FN3O4.H2O/c2*1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21;/h2*7-8,10H,3-6,9H2,1-2H3,(H,24,25);1H2/t2*10-;/m00./s1
Molecular Formula | H2O |
Molecular Weight | 18.0153 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C18H20FN3O4 |
Molecular Weight | 361.3675 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Levofloxacin is the L-isomer of the racemate, ofloxacin, a quinolone antimicrobial agent. Levofloxacin is used for oral and intravenous administration. Levofloxacin is sold under brand name levaquin and is used to treat infections in adults (≥18 years of age) caused by designated, susceptible bacteria such as, pneumonia: nosocomial and community acquired; skin and skin structure infections: complicated and uncomplicated; chronic bacterial prostatitis; inhalational anthrax. In addition this drug is used to treat plague; urinary tract infections: complicated and uncomplicated; acute pyelonephritis; acute bacterial exacerbation of chronic bronchitis and acute bacterial sinusitis. Levofloxacin, like other fluoroquinolones, inhibits the bacterial DNA gyrase, halting DNA replication. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing. In addition, levofloxacin inhibits a bacterial type II topoisomerase.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14506016
Curator's Comment: levofloxacin penetrates the cerebrospinal fluid (CSF) during meningeal inflammation both in animals and in humans
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2363033 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26525786 |
|||
Target ID: CHEMBL2311225 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26459538 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Curative | LEVAQUIN Approved UseLEVAQUIN is a fluoroquinolone antibacterial indicated in adults (≥18 years of age) with infections caused by designated, susceptible bacteria. Pneumonia: nosocomial and community acquired; skin and skin structure infections: complicated and uncomplicated; chronic bacterial prostatitis; inhalational anthrax. Post-Exposure and plague; urinary tract infections: complicated and uncomplicated; acute pyelonephritis; acute bacterial exacerbation of chronic bronchitis and acute bacterial sinusitis. Launch Date8.5104001E11 |
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Curative | LEVAQUIN Approved UseLEVAQUIN is a fluoroquinolone antibacterial indicated in adults (≥18 years of age) with infections caused by designated, susceptible bacteria. Pneumonia: nosocomial and community acquired; skin and skin structure infections: complicated and uncomplicated; chronic bacterial prostatitis; inhalational anthrax. Post-Exposure and plague; urinary tract infections: complicated and uncomplicated; acute pyelonephritis; acute bacterial exacerbation of chronic bronchitis and acute bacterial sinusitis. Launch Date8.5104001E11 |
|||
Curative | LEVAQUIN Approved UseLEVAQUIN is a fluoroquinolone antibacterial indicated in adults (≥18 years of age) with infections caused by designated, susceptible bacteria. Pneumonia: nosocomial and community acquired; skin and skin structure infections: complicated and uncomplicated; chronic bacterial prostatitis; inhalational anthrax. Post-Exposure and plague; urinary tract infections: complicated and uncomplicated; acute pyelonephritis; acute bacterial exacerbation of chronic bronchitis and acute bacterial sinusitis. Launch Date8.5104001E11 |
|||
Curative | LEVAQUIN Approved UseLEVAQUIN is a fluoroquinolone antibacterial indicated in adults (≥18 years of age) with infections caused by designated, susceptible bacteria. Pneumonia: nosocomial and community acquired; skin and skin structure infections: complicated and uncomplicated; chronic bacterial prostatitis; inhalational anthrax. Post-Exposure and plague; urinary tract infections: complicated and uncomplicated; acute pyelonephritis; acute bacterial exacerbation of chronic bronchitis and acute bacterial sinusitis. Launch Date8.5104001E11 |
|||
Curative | LEVAQUIN Approved UseLEVAQUIN is a fluoroquinolone antibacterial indicated in adults (≥18 years of age) with infections caused by designated, susceptible bacteria. Pneumonia: nosocomial and community acquired; skin and skin structure infections: complicated and uncomplicated; chronic bacterial prostatitis; inhalational anthrax. Post-Exposure and plague; urinary tract infections: complicated and uncomplicated; acute pyelonephritis; acute bacterial exacerbation of chronic bronchitis and acute bacterial sinusitis. Launch Date8.5104001E11 |
|||
Curative | LEVAQUIN Approved UseLEVAQUIN is a fluoroquinolone antibacterial indicated in adults (≥18 years of age) with infections caused by designated, susceptible bacteria. Pneumonia: nosocomial and community acquired; skin and skin structure infections: complicated and uncomplicated; chronic bacterial prostatitis; inhalational anthrax. Post-Exposure and plague; urinary tract infections: complicated and uncomplicated; acute pyelonephritis; acute bacterial exacerbation of chronic bronchitis and acute bacterial sinusitis. Launch Date8.5104001E11 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
7.9 mg/L |
500 mg 2 times / day multiple, intravenous dose: 500 mg route of administration: Intravenous experiment type: MULTIPLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
7.8 mg/L |
500 mg 2 times / day multiple, oral dose: 500 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
11.8 mg/L |
1000 mg 1 times / day multiple, oral dose: 1000 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
8.85 mg/L |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
2.04 mg/L |
200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
6.3 mg/L |
500 mg single, intravenous dose: 500 mg route of administration: Intravenous experiment type: SINGLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
49.6 mg × h/L |
500 mg 2 times / day multiple, intravenous dose: 500 mg route of administration: Intravenous experiment type: MULTIPLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
59 mg × h/L |
500 mg 2 times / day multiple, oral dose: 500 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
118 mg × h/L |
1000 mg 1 times / day multiple, oral dose: 1000 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
111 mg × h/L |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
19.88 mg × h/L |
200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
55.3 mg × h/L |
500 mg single, intravenous dose: 500 mg route of administration: Intravenous experiment type: SINGLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
7.6 h |
500 mg 2 times / day multiple, intravenous dose: 500 mg route of administration: Intravenous experiment type: MULTIPLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
8.4 h |
500 mg 2 times / day multiple, oral dose: 500 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
8.9 h |
1000 mg 1 times / day multiple, oral dose: 1000 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
7.9 h |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
5.97 h |
200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
6.6 h |
500 mg single, intravenous dose: 500 mg route of administration: Intravenous experiment type: SINGLE co-administered: |
LEVOFLOXACIN unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
250 mg 1 times / day multiple, oral Recommended Dose: 250 mg, 1 times / day Route: oral Route: multiple Dose: 250 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Disc. AE: Gastrointestinal disorder, Nausea... AEs leading to discontinuation/dose reduction: Gastrointestinal disorder (1.4%) Sources: Page: 19Nausea (0.6%) Vomiting (0.4%) Dizziness (0.3%) Headache (0.2%) |
500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Disc. AE: Gastrointestinal disorder, Nausea... AEs leading to discontinuation/dose reduction: Gastrointestinal disorder (1.4%) Sources: Page: 19Nausea (0.6%) Vomiting (0.4%) Dizziness (0.3%) Headache (0.2%) |
750 mg 1 times / day steady, oral Recommended Dose: 750 mg, 1 times / day Route: oral Route: steady Dose: 750 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Disc. AE: Gastrointestinal disorder, Nausea... AEs leading to discontinuation/dose reduction: Gastrointestinal disorder (1.2%) Sources: Page: 19Nausea (0.6%) Vomiting (0.5%) Dizziness (0.3%) Headache (0.3%) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Headache | 0.2% Disc. AE |
250 mg 1 times / day multiple, oral Recommended Dose: 250 mg, 1 times / day Route: oral Route: multiple Dose: 250 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Dizziness | 0.3% Disc. AE |
250 mg 1 times / day multiple, oral Recommended Dose: 250 mg, 1 times / day Route: oral Route: multiple Dose: 250 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Vomiting | 0.4% Disc. AE |
250 mg 1 times / day multiple, oral Recommended Dose: 250 mg, 1 times / day Route: oral Route: multiple Dose: 250 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Nausea | 0.6% Disc. AE |
250 mg 1 times / day multiple, oral Recommended Dose: 250 mg, 1 times / day Route: oral Route: multiple Dose: 250 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Gastrointestinal disorder | 1.4% Disc. AE |
250 mg 1 times / day multiple, oral Recommended Dose: 250 mg, 1 times / day Route: oral Route: multiple Dose: 250 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Headache | 0.2% Disc. AE |
500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Dizziness | 0.3% Disc. AE |
500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Vomiting | 0.4% Disc. AE |
500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Nausea | 0.6% Disc. AE |
500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Gastrointestinal disorder | 1.4% Disc. AE |
500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Dizziness | 0.3% Disc. AE |
750 mg 1 times / day steady, oral Recommended Dose: 750 mg, 1 times / day Route: oral Route: steady Dose: 750 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Headache | 0.3% Disc. AE |
750 mg 1 times / day steady, oral Recommended Dose: 750 mg, 1 times / day Route: oral Route: steady Dose: 750 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Vomiting | 0.5% Disc. AE |
750 mg 1 times / day steady, oral Recommended Dose: 750 mg, 1 times / day Route: oral Route: steady Dose: 750 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Nausea | 0.6% Disc. AE |
750 mg 1 times / day steady, oral Recommended Dose: 750 mg, 1 times / day Route: oral Route: steady Dose: 750 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Gastrointestinal disorder | 1.2% Disc. AE |
750 mg 1 times / day steady, oral Recommended Dose: 750 mg, 1 times / day Route: oral Route: steady Dose: 750 mg, 1 times / day Sources: Page: 19 |
unhealthy, mean 50 years n = 7537 Health Status: unhealthy Condition: infectious diseases Age Group: mean 50 years Sex: M+F Population Size: 7537 Sources: Page: 19 |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Drug as perpetrator
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/27853934/ Page: - |
inconclusive | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/19026171/ Page: - |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/27853934/ Page: - |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/27853934/ Page: - |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/27853934/ Page: - |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/27853934/ Page: - |
weak | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/19026171/ Page: - |
yes [IC50 210 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/16928358/ Page: - |
yes [IC50 6800 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/27853934/ Page: - |
yes | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/27853934/ Page: - |
yes |
Drug as victim
Tox targets
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/16474415/ Page: - |
PubMed
Title | Date | PubMed |
---|---|---|
Purification and inhibition by quinolones of DNA gyrases from Mycobacterium avium, Mycobacterium smegmatis and Mycobacterium fortuitum bv. peregrinum. | 1999 Sep |
|
Activity of moxifloxacin against mycobacteria. | 1999 Sep |
|
Antimycobacterial activities of novel levofloxacin analogues. | 2000 Aug |
|
In vitro activity of levofloxacin against coagulase-positive and -negative staphylococci. | 2001 |
|
Comparative pharmacokinetics and pharmacodynamics of the newer fluoroquinolone antibacterials. | 2001 |
|
The role of fluoroquinolones in tuberculosis today. | 2001 |
|
Activity of BMS284756 against 2,681 recent clinical isolates of Haemophilus influenzae and Moraxella catarrhalis: Report from The SENTRY Antimicrobial Surveillance Program (2000) in Europe, Canada and the United States. | 2001 Apr |
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Enantioseparation of ofloxacin in urine by capillary electrokinetic chromatography using charged cyclodextrins as chiral selectors and assessment of enantioconversion. | 2001 Apr |
|
[Injectable quinolones]. | 2001 Apr |
|
Steady-state plasma and intrapulmonary concentrations of levofloxacin and ciprofloxacin in healthy adult subjects. | 2001 Apr |
|
Inhibitory activity of quinolones against DNA gyrase of Mycobacterium tuberculosis. | 2001 Apr |
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A nosocomial outbreak of fluoroquinolone-resistant Streptococcus pneumoniae. | 2001 Aug 15 |
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Quinolones alter defense reactions mediated by macrophages. | 2001 Feb |
|
Workplace costs associated with acute exacerbation of chronic bronchitis: a comparison of moxifloxacin and levofloxacin. | 2001 Feb |
|
Lack of interaction between levofloxacin and oxycodone: pharmacokinetics and drug disposition. | 2001 Feb |
|
Effects of common topical otic preparations on the morphology of isolated cochlear outer hair cells. | 2001 Jan |
|
[In vitro antimycobacterial activities of a new quinolone, balofloxacin]. | 2001 Jan |
|
In vitro activity of ketolides HMR 3004 and HMR 3647 and seven other antimicrobial agents against Corynebacterium diphtheriae. | 2001 Jan |
|
New directions in antiinfective therapy for community-acquired pneumonia in the emergency department. | 2001 Jul |
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A controlled trial of a critical pathway for treating community-acquired pneumonia: the CAPITAL study. Community-Acquired Pneumonia Intervention Trial Assessing Levofloxacin. | 2001 Jul |
|
Comparison of in-vitro activities of SCH27899 and other antibiotics against Mycoplasma pneumoniae. | 2001 Jun |
|
Susceptibility of Canadian isolates of Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae to oral antimicrobial agents. | 2001 Jun |
|
Activity of oral agents against pediatric isolates of Streptococcus pneumoniae. | 2001 Mar |
|
Antidepressant, anxiogenic, and antinociceptive properties of levofloxacin in rats and mice. | 2001 Mar |
|
Treatment of tularemia with levofloxacin. | 2001 Mar |
|
In vitro activity of four fluoroquinolones against Mycobacterium tuberculosis. | 2001 Mar |
|
Antimicrobial activity of fluoroquinolone photodegradation products determined by parallel-line bioassay and high performance liquid chromatography. | 2001 Mar |
|
Clinical perspectives on new antimicrobials: focus on fluoroquinolones. | 2001 Mar 15 |
|
Active intestinal secretion of new quinolone antimicrobials and the partial contribution of P-glycoprotein. | 2001 May |
|
Activity of moxifloxacin and other quinolones against pneumococci resistant to first-line agents, or with high-level ciprofloxacin resistance. | 2001 May |
|
An HPLC assay and a microbiological assay to determine levofloxacin in soft tissue, bone, bile and serum. | 2001 May |
|
Activity of BMS284756 (T-3811) tested against anaerobic bacteria, Campylobacter jejuni, Helicobacter pylori and Legionella spp. | 2001 May-Jun |
|
In vitro activity of ABT-773 versus macrolides and quinolones against resistant respiratory tract pathogens. | 2001 May-Jun |
|
Molecular epidemiology and mutations at gyrA and parC genes of ciprofloxacin-resistant Escherichia coli isolates from a Taiwan medical center. | 2001 Spring |
|
In vitro activity of 19 antimicrobial agents against enterococci from healthy subjects and hospitalized patients and use of an ace gene probe from Enterococcus faecalis for species identification. | 2001 Spring |
Sample Use Guides
The usual dose of LEVAQUIN tablets or oral solution is 250 mg, 500 mg, or 750 mg administered orally every 24 hours. The usual dose of LEVAQUIN Injection is 250 mg or 500 mg administered by slow infusion over 60 minutes every 24 hours or 750 mg administered by slow infusion over 90 minutes every 24 hours.
Nosocomial Pneumonia: 750 mg during 7–14 days
Community Acquired Pneumonia: 500 mg during 7–14 days
Community Acquired Pneumonia§ 750 mg during 5 days
Complicated Skin and Skin Structure Infections (SSSI) 750 mg during 7–14 days
Uncomplicated SSSI 500 mg during 7–10 days
Chronic Bacterial Prostatitis 500 mg during 28 days
Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) 750 mg during 5 days
Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) 250 mg during 10 days
Uncomplicated Urinary Tract Infection 250 mg 3 during days
Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB) 500 mg during 7 days
Acute Bacterial Sinusitis (ABS) 750 mg days or 500 mg during 10–14 days.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8077990
Levofloxacin was compared to ofloxacin and ciprofloxacin against > 6000 recent clinical isolates of Gram-positive and Gram-negative bacteria from six different countries. This international multicenter study demonstrated a high level of antibacterial activity of levofloxacin against all the members of Enterobacteriaceae [minimum inhibitory concentration (MIC)50s, < or = 0.03 to 0.12 mg/L] except Providencia rettgeri (MIC50, 2 mg/L), and Providencia stuartii (MIC50, 1 mg/L). Levofloxacin was also active against non-enteric Gram-negative bacilli, including Acinetobacter species (MIC50s, < or = 0.03 to 1 mg/L), Pseudomonas species (MIC50s, 0.5 to 1 mg/L) and Xanthomonas maltophilia (MIC50, 0.5 mg/L). Overall, levofloxacin inhibited 50% and 90% of all the tested strains at the concentrations of 0.12 and 4 mg/L, respectively. The activity of levofloxacin was generally two-fold greater than ofloxacin and equal to or slightly less potent than ciprofloxacin.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 16 17:17:08 UTC 2022
by
admin
on
Fri Dec 16 17:17:08 UTC 2022
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Record UNII |
6GNT3Y5LMF
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Record Status |
Validated (UNII)
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Record Version |
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-
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Classification Tree | Code System | Code | ||
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WHO-ATC |
S01AE05
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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WHO-ATC |
A02BD10
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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NDF-RT |
N0000007606
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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FDA ORPHAN DRUG |
253707
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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WHO-ATC |
J01MA12
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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LIVERTOX |
NBK548357
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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NDF-RT |
N0000175937
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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NCI_THESAURUS |
C795
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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EU-Orphan Drug |
EU/3/08/566
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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WHO-VATC |
QS01AE05
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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WHO-VATC |
QJ01RA05
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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WHO-ATC |
J01RA05
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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EMA ASSESSMENT REPORTS |
QUINSAIR (AUTHORIZED: CYSTIC FIBROSIS)
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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WHO-VATC |
QJ01MA12
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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Code System | Code | Type | Description | ||
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C1586
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | |||
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1362103
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | |||
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6GNT3Y5LMF
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | |||
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DTXSID60160533
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | |||
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6GNT3Y5LMF
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | |||
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LEVOFLOXACIN
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | |||
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1569
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | |||
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63598
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | |||
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II-30
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | |||
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SUB21640
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | |||
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138199-71-0
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | |||
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M8133
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | |||
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3033924
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | |||
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Levofloxacin
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | |||
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DB01137
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | |||
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82122
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY | RxNorm | ||
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CHEMBL33
Created by
admin on Fri Dec 16 17:17:08 UTC 2022 , Edited by admin on Fri Dec 16 17:17:08 UTC 2022
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PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
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BINDER->LIGAND |
ROUTE OF ADMINISTRATION: ORAL AND INJECTION
BINDING
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BASIS OF STRENGTH->SUBSTANCE |
ASSAY (HPLC)
USP
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PARENT -> SALT/SOLVATE | |||
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ANHYDROUS->SOLVATE |
Related Record | Type | Details | ||
---|---|---|---|---|
|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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Related Record | Type | Details | ||
---|---|---|---|---|
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ACTIVE MOIETY |
Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
---|---|---|---|---|---|---|
MIC | PHARMACOKINETIC |
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SUSCEPTIBILITY: RESISTANT |
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MIC | BIOLOGICAL |
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SUSCEPTIBILITY: SUSCEPTIBLE |
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Volume of Distribution | PHARMACOKINETIC |
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POPULATION: INFANTS ? 6 MONTHS, CHILDREN, AND ADOLESCENTS ? 16 YEARS |
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Biological Half-life | PHARMACOKINETIC |
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POPULATION: CHILDREN 12-16 YEARS |
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Biological Half-life | PHARMACOKINETIC |
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POPULATION: CHILDREN 5-10 YEARS |
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Tmax | PHARMACOKINETIC |
|
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|||
MIC | PHARMACOKINETIC |
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SUSCEPTIBILITY: SUSCEPTIBLE |
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Biological Half-life | PHARMACOKINETIC |
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POPULATION: ADULTS WITH RENAL IMPAIRMENT (CrCL < 20 ML/MIN) |
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Biological Half-life | PHARMACOKINETIC |
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POPULATION: CHILDREN 10-12 YEARS |
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ORAL BIOAVAILABILITY | PHARMACOKINETIC |
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ROUTE OF ADMINISTRATION: ORAL |
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Biological Half-life | PHARMACOKINETIC |
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POPULATION: ADULTS WITH RENAL IMPAIRMENT (CrCL 20-49 ML/MIN) |
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Volume of Distribution | PHARMACOKINETIC |
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POPULATION: ADULTS |
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Biological Half-life | PHARMACOKINETIC |
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POPULATION: INFANTS ? 6 MONTHS AND CHILDREN ? 5 YEARS |
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Biological Half-life | PHARMACOKINETIC |
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POPULATION: ADULTS |
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MIC | PHARMACOKINETIC |
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SUSCEPTIBILITY: INTERMEDIATE |
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