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Details

Stereochemistry ACHIRAL
Molecular Formula C14H27O2.H4N
Molecular Weight 245.4014
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMMONIUM MYRISTATE

SMILES

[NH4+].CCCCCCCCCCCCCC([O-])=O

InChI

InChIKey=BJOYVZZDDFVLPI-UHFFFAOYSA-N
InChI=1S/C14H28O2.H3N/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16;/h2-13H2,1H3,(H,15,16);1H3

HIDE SMILES / InChI

Molecular Formula C14H28O2
Molecular Weight 228.3709
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H3N
Molecular Weight 17.0305
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Ammonium myristate is passage-delaying substance. It was used as a substance for influencing gastrointestinal passage. The addition of ammonium myristate caused a delay of about 1.5 h in the transit time of the absorbing part of the gastrointestinal tract. The addition of ammonium myristate improves the availability of nitrofurantoin from a slow releasing dosage form - an average increase is 23.8% of the total amount of nitrofurantoin excreted in the urine compared to the values obtained from the reference dosage form without the additional substance. The kinetics of renal elimination of nitrofurantoin is characterized by the longer duration of urinary excretion.

CNS Activity

Curator's Comment: Known to be CNS penetrant in rats. Human data not available.

Originator

Sources: DOI: 10.1080/14786444108650255

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Unknown

Approved Use

Unknown
Diagnostic
Unknown

Approved Use

Unknown
Inactive ingredient
Volu-Firm

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Longitudinal study of fatty acids in plasma and erythrocyte phospholipids during pregnancy.
2001
Thioacylation is required for targeting G-protein subunit G(o1alpha) to detergent-insoluble caveolin-containing membrane domains.
2001 Apr 15
Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallography.
2001 Apr 27
Flunitrazepam, a 7-nitro-1,4-benzodiazepine that is unable to bind to the indole-benzodiazepine site of human serum albumin.
2001 Apr 7
Fatty acid synthesis in African trypanosomes: a solution to the myristate mystery.
2001 Aug
A new double coupling system: synthesis of citronellyl acetate via transacetylation to citronellol from acetyl coenzyme A produced from glucose and free fatty acids.
2001 Aug
Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells.
2001 Aug
Biosynthesis and structural characterization of medium-chain-length poly(3-hydroxyalkanoates) produced by Pseudomonas aeruginosa from fatty acids.
2001 Aug 20
beta-Ketoacyl-[acyl carrier protein] synthase I of Escherichia coli: aspects of the condensation mechanism revealed by analyses of mutations in the active site pocket.
2001 Aug 21
Overexpression of the myristoylated alanine-rich C-kinase substrate inhibits cell adhesion to extracellular matrix components.
2001 Aug 24
Regulation of Golgi structure and function by ARF-like protein 1 (Arl1).
2001 Dec
Palmitate decreases proton pumping of liver-type cytochrome c oxidase.
2001 Dec
Characterization of the binding of Photobacterium phosphoreum P-flavin by Vibrio harveyi Luciferase.
2001 Dec 15
Cellular and viral Fos proteins are degraded by different proteolytic systems.
2001 Feb 22
Activation of ion-conducting pathways in the inner mitochondrial membrane - an unrecognized activity of fatty acid?
2001 Feb 23
[Determination of higher fatty acids in human plasma].
2001 Jul
Molecular characterization of StCDPK1, a calcium-dependent protein kinase from Solanum tuberosum that is induced at the onset of tuber development.
2001 Jul
Fatty acid remodeling of glycosyl phosphatidylinositol anchors in Trypanosoma brucei: incorporation of fatty acids other than myristate.
2001 Jul
Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands.
2001 Jul 6
Differential mechanisms of glucose and palmitate in augmentation of insulin secretion in mouse pancreatic islets.
2001 Jun
Cox-2 inhibitory effects of naturally occurring and modified fatty acids.
2001 Jun
Copper-catalyzed coupling of arylboronic acids and amines.
2001 Jun 28
Crystallographic phasing of myristoyl-CoA-protein N-myristoyltransferase using an iodinated analog of myristoyl-CoA.
2001 Mar
Regulation of G proteins by covalent modification.
2001 Mar 26
N-terminal myristylation of HBV preS1 domain enhances receptor recognition.
2001 May
Morbid myristoylation.
2001 May
Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis.
2001 May 29
Fatty acid profiles of nitrite-oxidizing bacteria reflect their phylogenetic heterogeneity.
2001 Nov
Enzyme activity of the cytochrome P-450 monooxygenase system in the presence of single chain lipid molecules.
2001 Nov-Dec
Regulation of IL-13 production by histamine in cloned murine T helper type 2 cells.
2001 Oct
Effects of incubator humidity and hen age on yolk composition in broiler hatching eggs from young breeders.
2001 Oct
Ethanol- and nicotine-induced membrane changes in embryonic and neonatal chick brains.
2001 Oct
Deletion of N-terminal myristoylation site of HIV Nef abrogates both MHC-1 and CD4 down-regulation.
2001 Oct 1
Phosphorylation of human N-myristoyltransferase by N-myristoylated SRC family tyrosine kinase members.
2001 Oct 19
Propranolol increases phosphatidic acid level via activation of phospholipase D.
2001 Sep
Rat pancreatic acinar cells express a cytosolic phospholipase D1b isoform that is not regulated by cholecystokinin.
2001 Sep
Optimization of carbohydrate fatty acid ester synthesis in organic media by a lipase from Candida antarctica.
2001 Sep 20
Differential effect of valproate and its Delta2- and Delta4-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids.
2001 Sep 28
Coexpression of proteins with methionine aminopeptidase and/or N-myristoyltransferase in Escherichia coli to increase acylation and homogeneity of protein preparations.
2002
Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction.
2002 Apr 19
Myristoylated alanine-rich C kinase substrate (MARCKS) sequesters spin-labeled phosphatidylinositol 4,5-bisphosphate in lipid bilayers.
2002 Apr 19
Myristyl and palmityl acylation of pI 5.1 carboxylesterase from porcine intestine and liver.
2002 Feb
Differences in the fatty acid composition of larvae and metamorphosing sea lampreys, Petromyzon marinus.
2002 Feb
Oxidative stress induced cytokine production in isolated rat pancreatic acinar cells: effects of small-molecule antioxidants.
2002 Feb
Serum free fatty acid pattern and risk of myocardial infarction: a case-control study.
2002 Jan
[Fatty acid-induced reversal of general anesthesia: chain length-dependence of antagonizing potencies of fatty acids].
2002 Jan
Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease.
2002 Jan
Permeation of a myristoylated dipeptide across the buccal mucosa: topological distribution and evaluation of tissue integrity.
2002 Jan 1
Interaction of bovine (BSA) and human (HSA) serum albumins with ionic surfactants: spectroscopy and modelling.
2002 Jan 31
The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase.
2002 Jan 4
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Rous sarcoma virus-transformed cells were labeled for 2 h with either 1 mCi of [3H]palmitic acid or 0.2 mCi of [3H]myristic acid, and p60src was isolated by immunoprecipitation. The incorporation of [3H]myristic acid into p60src was ca. 100-fold greater than the incorporation of [3H]palmitic acid.
Substance Class Chemical
Created
by admin
on Sat Dec 16 09:08:08 GMT 2023
Edited
by admin
on Sat Dec 16 09:08:08 GMT 2023
Record UNII
6FX8H1ODBK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMMONIUM MYRISTATE
Systematic Name English
TETRADECANOIC ACID, AMMONIUM SALT
Common Name English
INS NO.470(I)MYRISTIC ACID, AMMONIUM SALT
Common Name English
MYRISTIC ACID, AMMONIUM SALT
Common Name English
E-470(I)MYRISTIC ACID, AMMONIUM SALT
Common Name English
INS-470(I)MYRISTIC ACID, AMMONIUM SALT
Common Name English
Classification Tree Code System Code
CODEX ALIMENTARIUS (GSFA) INS-470(I)
Created by admin on Sat Dec 16 09:08:08 GMT 2023 , Edited by admin on Sat Dec 16 09:08:08 GMT 2023
JECFA EVALUATION INS-470(I)
Created by admin on Sat Dec 16 09:08:08 GMT 2023 , Edited by admin on Sat Dec 16 09:08:08 GMT 2023
Code System Code Type Description
CAS
16530-71-5
Created by admin on Sat Dec 16 09:08:08 GMT 2023 , Edited by admin on Sat Dec 16 09:08:08 GMT 2023
PRIMARY
EPA CompTox
DTXSID00167884
Created by admin on Sat Dec 16 09:08:08 GMT 2023 , Edited by admin on Sat Dec 16 09:08:08 GMT 2023
PRIMARY
FDA UNII
6FX8H1ODBK
Created by admin on Sat Dec 16 09:08:08 GMT 2023 , Edited by admin on Sat Dec 16 09:08:08 GMT 2023
PRIMARY
PUBCHEM
167548
Created by admin on Sat Dec 16 09:08:08 GMT 2023 , Edited by admin on Sat Dec 16 09:08:08 GMT 2023
PRIMARY
ECHA (EC/EINECS)
240-599-8
Created by admin on Sat Dec 16 09:08:08 GMT 2023 , Edited by admin on Sat Dec 16 09:08:08 GMT 2023
PRIMARY