HALOPREDONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H25BrF2O5
Molecular Weight	475.321
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])C[C@@H](F)C4=CC(=O)C(Br)=C[C@]34C

InChI

InChIKey=MYZDPUZXMFCPMU-LRIWMWCYSA-N

InChI=1S/C21H25BrF2O5/c1-18-8-16(27)21(24)11(10(18)3-4-20(18,29)17(28)9-25)5-14(23)12-6-15(26)13(22)7-19(12,21)2/h6-7,10-11,14,16,25,27,29H,3-5,8-9H2,1-2H3/t10-,11-,14+,16-,18-,19-,20-,21-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H25BrF2O5
Molecular Weight	475.321
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/3957156
Curator's Comment: description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/341904

Halopredone (THS-201; (17,21-bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione; halopredone acetate; Topicon) is a highly topical corticosteroid. When it is used for intraarticular injections, the effects last longer than any other steroids which have been used, and it has less general effects. Halopredone acetate is used for arthritis and osteoarthritis (OA) patients. For RA patients, mean dose for a wrist is 12.5 mg and that for a knee is 25 mg. About 90% cases showed effectiveness and in about 45% cases the duration of effect is longer than 4 weeks. More than half cases of OA showed also improvements. It also possesses positive anti-inflammatory properties in dermatologic patients.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Arthritis 89 Sources: http://www.ncbi.nlm.nih.gov/pubmed/3718077	Primary		Preclinical	Unknown Approved Use Unknown
Dermatoses 23 Sources: http://www.ncbi.nlm.nih.gov/pubmed/341904	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

for rats: locally: 80 micrograms/pellet s.c.: 100 mg/kg

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:33:29 GMT 2023` Edited by `admin` on `Fri Dec 15 18:33:29 GMT 2023`
Record UNII	6F4361R42W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HALOPREDONE

Official Name

English

halopredone [INN]

Common Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 2-BROMO-6,9-DIFLUORO-11,17,21-TRIHYDROXY-, (6.BETA.,11.BETA.)-

Systematic Name

English

Halopredone [WHO-DD]

Common Name

English

Code System Code Type Description

WIKIPEDIA

Halopredone