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OLIPUDASE ALFA
6D5766Q4OP
US Approved Rx (2022)
First approved in 2022
General
Record Details
Variant Concepts
1
Names
11
Classification
2
Identifiers
10
Subunits
1
Disulfide Links
8
Glycosylation
6
Relationships
1
Active Moiety
1
Characteristic Attributes
2
OLIPUDASE ALFA
6D5766Q4OP
US Approved Rx (2022)
First approved in 2022
General
Approval Year
2022
358
Record Details
Substance Class
Protein
Protein Type
ENZYME
Protein Sub Type
Sequence Origin
HUMAN
Sequence Type
COMPLETE
Record UNII
6D5766Q4OP
Record Status
Validated (UNII)
Record Version
27
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Type
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Names
11
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entries
Name
Type
Language
Name
Type
Language
OLIPUDASE ALFA
Official Name
English
RECOMBINANT HUMAN ACID SPHINGOMYELINASE
Common Name
English
RECOMBINANT DNA DERIVED DES-(1-13)-HUMAN SPHINGOMYELIN PHOSPHODIESTERASE
Common Name
English
RHASM
Code
English
OLIPUDASE ALFA [USAN]
Common Name
English
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Classification
2
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Classification Tree
Code System
Code
Classification Tree
Code System
Code
Positive
EU ORPHAN DRUG
Positive
Treatment of Niemann-Pick disease
EU-Orphan Drug
EU/3/01/056
Designated/Approved
ORPHAN DRUG
Designated/Approved
Treatment of acid sphingomyelinase deficiency (Niemann-Pick disease)
FDA ORPHAN DRUG
132900
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Identifiers
10
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Code System
Code
Type
Description
Code System
Code
Type
Description
FDA UNII
6D5766Q4OP
PRIMARY
DAILYMED
6D5766Q4OP
PRIMARY
NCI_THESAURUS
C166929
PRIMARY
CAS
927883-84-9
PRIMARY
EC (ENZYME CLASS)
EC 3.1.4.12
PRIMARY
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Subunits
1
Subunit 0
>SUBUNIT_0
Disulfide Links
8
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From
To
From
To
1_30
1_106
1_33
1_98
1_61
1_72
1_162
1_167
1_168
1_191
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Glycosylation
6
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Glycosylation Link Type
Site
Glycosylation Link Type
Site
N
1_27
N
1_116
N
1_276
N
1_336
N
1_444
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Relationships
1
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Related Record
Type
Details
Related Record
Type
Details
Olipudase Alfa-RPCP
SUB_CONCEPT->SUBSTANCE
Amount:
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Active Moiety
1
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Related Record
Type
Details
Related Record
Type
Details
6D5766Q4OP
OLIPUDASE ALFA
ACTIVE MOIETY
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Characteristic Attributes
2
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Name
Property Type
Amount
Referenced Substance
Defining
Parameters
References
Name
Property Type
Amount
Referenced Substance
Defining
Parameters
References
Molecular Formula
CHEMICAL
ESTIMATED
C2900H4369N783O791S24
MOL_WEIGHT:NUMBER(CALCULATED)
CHEMICAL
ESTIMATED 63600 Da (average)
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