Details
Stereochemistry | ACHIRAL |
Molecular Formula | C8H4N2S2 |
Molecular Weight | 192.261 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 2 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
S=C=NC1=CC=C(C=C1)N=C=S
InChI
InChIKey=OMWQUXGVXQELIX-UHFFFAOYSA-N
InChI=1S/C8H4N2S2/c11-5-9-7-1-2-8(4-3-7)10-6-12/h1-4H
Molecular Formula | C8H4N2S2 |
Molecular Weight | 192.261 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 2 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/769080Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/769078 | https://www.ncbi.nlm.nih.gov/pubmed/955553 | https://www.ncbi.nlm.nih.gov/pubmed/769062 | https://www.ncbi.nlm.nih.gov/pubmed/26639764
Sources: https://www.ncbi.nlm.nih.gov/pubmed/769080
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/769078 | https://www.ncbi.nlm.nih.gov/pubmed/955553 | https://www.ncbi.nlm.nih.gov/pubmed/769062 | https://www.ncbi.nlm.nih.gov/pubmed/26639764
Bitoscanate is a tasteless, odorless, colorless, needle-like crystalline solid material prepared from mustard powder acid and used as an anthelmintic against nematodes, especially hookworms (Necator sp.) and Ancylostoma duodenale. Side effects reported with therapeutic use have been nausea, vomiting, diarrhea, abdominal pain or discomfort, loss of appetite, dizziness or giddiness, vertigo, weakness, headache, and an itching sensation over the body. Such side effects have most often been mild and required no treatment. Bitoscanate is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Optimizing the immobilization of single-stranded DNA onto glass beads. | 2001 Feb 26 |
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C-terminal sequence analysis of peptides using triphenylgermanyl isothiocyanate. | 2002 Mar 1 |
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Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. | 2004 May 1 |
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Suppressive effect of 1,4-phenylene diisothiocyanate on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice. | 2005 Nov 20 |
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A Novel Label-Free Optical Biosensor Using Synthetic Oligonucleotides from E. coli O157:H7: Elementary Sensitivity Tests. | 2009 |
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Surface immobilisation of antibody on cyclic olefin copolymer for sandwich immunoassay. | 2009 Apr 15 |
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The specific isolation of C-terminal peptides of proteins through a transamination reaction and its advantage for introducing functional groups into the peptide. | 2009 Mar |
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p-Isothiocyanatobenzyl-desferrioxamine: a new bifunctional chelate for facile radiolabeling of monoclonal antibodies with zirconium-89 for immuno-PET imaging. | 2010 Feb |
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Immobilization of trypsin onto 1,4-diisothiocyanatobenzene-activated porous glass for microreactor-based peptide mapping by capillary electrophoresis: effect of calcium ions on the immobilization procedure. | 2010 Mar 24 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/769062
2X 50 mg (50 mg at. 12-hourly intervals)
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26639764
The antiproliferative activity of Bitoscanate was evaluated on the human colon adenocarcinoma cell line (LoVo) and the doxorubicin-resistant human colon adenocarcinoma cell line (LoVo/DX) by means of the sulforhodamine B (SRB) assay. The impact of the compounds under study on cells viability is presented as a 50% growth inhibitory concentration (IC50) with doxorubicin used as reference. Bitoscanate shows moderate antiproliferative activity with IC50 = 9.41 mkM (LoVo) and 11.6 mkM (LoVo/DX)
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 16:52:37 GMT 2023
by
admin
on
Sat Dec 16 16:52:37 GMT 2023
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Record UNII |
6D1R3P86GX
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C250
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2397
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CHEMBL2104676
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223-741-3
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DTXSID3046532
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3033
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6435
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6D1R3P86GX
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100000086324
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SUB05861MIG
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19958
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C032582
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758884
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C72149
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BITOSCANATE
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4044-65-9
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m2579
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PRIMARY | Merck Index |
Related Record | Type | Details | ||
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ACTIVE MOIETY |