TEBUQUINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H25Cl2N3O
Molecular Weight	466.402
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)NCC1=C(O)C(=CC(NC2=CC=NC3=CC(Cl)=CC=C23)=C1)C4=CC=C(Cl)C=C4

InChI

InChIKey=BCHMRNALCJISMZ-UHFFFAOYSA-N

InChI=1S/C26H25Cl2N3O/c1-26(2,3)30-15-17-12-20(14-22(25(17)32)16-4-6-18(27)7-5-16)31-23-10-11-29-24-13-19(28)8-9-21(23)24/h4-14,30,32H,15H2,1-3H3,(H,29,31)

HIDE SMILES / InChI

Molecular Formula	C26H25Cl2N3O
Molecular Weight	466.402
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9046333 | https://www.ncbi.nlm.nih.gov/pubmed/6398032

Tebuquine (also known as WR 228,258) is an antimalarial agent that is significantly more active than amodiaquine and chloroquine and was the most active compound tested against both strains of Plasmodia. Information about the current use of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Synthesis, antimalarial activity, and quantitative structure-activity relationships of tebuquine and a series of related 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl] [1,1'-biphenyl]-2-ols and N omega-oxides.	1986-06	3712383
The chemotherapy of rodent malaria, XXXVIII. Studies on the activity of three new antimalarials (WR 194,965, WR 228,258 and WR 225,448) against rodent and human malaria parasites (Plasmodium berghei and P. falciparum).	1984-12	6398032
The chemotherapy of rodent malaria, XXXVII. The in vivo action of two Mannich bases, WR 194,965 and WR 228,258 and an 8-aminoquinoline WR 225,448.	1984-12	6532327

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:30:53 GMT 2025` Edited by `admin` on `Mon Mar 31 18:30:53 GMT 2025`
Record UNII	699Q1XT4EN
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CI-897

Preferred Name

English

TEBUQUINE

Official Name

English

tebuquine [INN]

Common Name

English

WR-228258

Code

English

TEBUQUINE [USAN]

Common Name

English

WR-228,258

Code

English

Code System Code Type Description

NCI_THESAURUS

C75270