TEBUQUINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H25Cl2N3O
Molecular Weight	466.402
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)NCC1=C(O)C(=CC(NC2=CC=NC3=CC(Cl)=CC=C23)=C1)C4=CC=C(Cl)C=C4

InChI

InChIKey=BCHMRNALCJISMZ-UHFFFAOYSA-N

InChI=1S/C26H25Cl2N3O/c1-26(2,3)30-15-17-12-20(14-22(25(17)32)16-4-6-18(27)7-5-16)31-23-10-11-29-24-13-19(28)8-9-21(23)24/h4-14,30,32H,15H2,1-3H3,(H,29,31)

HIDE SMILES / InChI

Molecular Formula	C26H25Cl2N3O
Molecular Weight	466.402
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9046333 | https://www.ncbi.nlm.nih.gov/pubmed/6398032

Tebuquine (also known as WR 228,258) is an antimalarial agent that is significantly more active than amodiaquine and chloroquine and was the most active compound tested against both strains of Plasmodia. Information about the current use of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
The chemotherapy of rodent malaria, XXXVIII. Studies on the activity of three new antimalarials (WR 194,965, WR 228,258 and WR 225,448) against rodent and human malaria parasites (Plasmodium berghei and P. falciparum).	1984 Dec	6398032
Synthesis, antimalarial activity, and quantitative structure-activity relationships of tebuquine and a series of related 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl] [1,1'-biphenyl]-2-ols and N omega-oxides.	1986 Jun	3712383

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:32:36 GMT 2023` Edited by `admin` on `Fri Dec 15 16:32:36 GMT 2023`
Record UNII	699Q1XT4EN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TEBUQUINE

Official Name

English

tebuquine [INN]

Common Name

English

CI-897

Code

English

WR-228258

Code

English

TEBUQUINE [USAN]

Common Name

English

WR-228,258

Code

English

Code System Code Type Description

NCI_THESAURUS

C75270