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Details

Stereochemistry ACHIRAL
Molecular Formula C8H11N.ClH
Molecular Weight 157.641
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 2,6-XYLIDINE HYDROCHLORIDE

SMILES

Cl.CC1=CC=CC(C)=C1N

InChI

InChIKey=QNWMFJDRMZWZNN-UHFFFAOYSA-N
InChI=1S/C8H11N.ClH/c1-6-4-3-5-7(2)8(6)9;/h3-5H,9H2,1-2H3;1H

HIDE SMILES / InChI
Molecular Formula C8H11N
Molecular Weight 121.1796
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure.
1993 Jul
An update of the National Toxicology Program database on nasal carcinogens.
1997 Oct 31
Tumor-promoting activity of 2,6-dimethylaniline in a two-stage nasal carcinogenesis model in N-bis(2-hydroxypropyl)nitrosamine-treated rats.
1999 Aug 3
Sequential observation of 2,6-dimethylaniline-induced nasal lesions in a rat two-stage nasal carcinogenesis model after initiation with N-bis(2-hydroxypropyl) nitrosamine.
2000 Jul
Determination of the levels of aromatic amines in indoor and outdoor air in Italy.
2001 Apr
Synthesis, characterization, and comparative 32P-postlabeling efficiencies of 2,6-dimethylaniline-DNA adducts.
2001 Feb
Oxidation of 2,6-dimethylaniline by recombinant human cytochrome P450s and human liver microsomes.
2001 Jun
Plasma levels of lidocaine and prilocaine after application of Oraqix, a new intrapocket anesthetic, in patients with advanced periodontitis.
2001 May
Involvement of liver carboxylesterases in the in vitro metabolism of lidocaine.
2002 Jun
Asymmetric synthesis of axially chiral benzamides and anilides by enantiotopic lithiation of prochiral arene chromium complexes.
2002 Mar 22
The effect of deuterium and fluorine substitution upon the mutagenicity of N-hydroxy-2,6-dimethylaniline.
2002 Sep 30
Pharmacokinetics of xylazine, 2,6-dimethylaniline, and tolazoline in tissues from yearling cattle and milk from mature dairy cows after sedation with xylazine hydrochloride and reversal with tolazoline hydrochloride.
2003 Summer
Determination of xylazine and its metabolites by GC-MS in equine urine for doping analysis.
2004 Apr 1
Synthesis, structure and pharmacology of acyl-2,6-xylidines.
2004 May-Jun
Metabolic activation of 2,6-xylidine in the nasal olfactory mucosa and the mucosa of the upper alimentary and respiratory tracts in rats.
2004 Oct
Alkylaniline-hemoglobin adducts and risk of non-smoking-related bladder cancer.
2004 Oct 6
Regioselective copper-catalyzed amination of chlorobenzoic acids: synthesis and solid-state structures of N-aryl anthranilic acid derivatives.
2006 Jan 6
Similarities and differences between azomethines and ketimines: synthesis, materials characterization and structure of novel imines compounds.
2007 Apr
Expedient syntheses of the N-heterocyclic carbene precursor imidazolium salts IPr.HCl, IMes.HCl and IXy.HCl.
2007 Aug 28
N-(5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-ylcarbon-yl)-N'-(2,6-dimethyl-phen-yl)thio-urea.
2007 Dec 6
Temperature investigations of E/Z isomers in ketimines based of p-dibenzoylobenzene with aniline and 2,6-dimethylaniline by infrared spectroscopy.
2007 Oct
N-(2,6-Dimethyl-phen-yl)benzene-sulfonamide.
2008 Aug 6
The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase.
2008 Dec 15
Quantitative mass spectrometric analysis of ropivacaine and bupivacaine in authentic, pharmaceutical and spiked human plasma without chromatographic separation.
2008 May 28
Kinetics and mechanism of 2,6-dimethyl-aniline degradation by hydroxyl radicals.
2009 Dec 30
N-(2,6-Dimethyl-phen-yl)succinamic acid.
2009 Feb 6
Kinetics of 2,6-dimethylaniline degradation by electro-Fenton process.
2009 Jan 30
N-[3-(2,6-Dimethylanilino)-1-methylbut-2-enylidene]-2,6-dimethylanilinium chloride.
2009 Jun 24
Mixed carbene-isocyanide Pd(II) complexes: synthesis, structures and reactivity towards nucleophiles.
2009 Mar 28
N-(2,6-Dimethyl-phen-yl)maleamic acid.
2009 Oct 23
Separation and analysis of dimethylaniline isomers by supercritical fluid chromatography--electrospray ionization tandem mass spectrometry.
2009 Oct 9
Drug impurity profiling by capillary electrophoresis/mass spectrometry using various ionization techniques.
2009 Sep
Chemical oxidation of 2,6-dimethylaniline by electrochemically generated Fenton's reagent.
2010 Apr 15
N-(2,6-Dimethyl-phen-yl)-4-methyl-benzene-sulfonamide.
2010 Apr 24
N-(2,6-Dimethyl-phen-yl)succinimide.
2010 Jan 9
Third-order nonlinear optical properties and structures of (E)-N-(4-nitrobenzylidene)-2,6-dimethylaniline and (E)-N-(4-nitrobenzylidene)-2,3-dimethylaniline.
2010 May
Investigating the mechanisms of aromatic amine-induced protein free radical formation by quantitative structure-activity relationships: implications for drug-induced agranulocytosis.
2010 May 17
HPLC-DAD stability indicating determination of nitrofurazone and lidocaine hydrochloride in their combined topical dosage form.
2010 Sep
Patents

Patents

03966811
2
04034108
3
04046554
2
04147804
3
04188341
2
04203904
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04243819
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04275079
2
04291049
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04411912
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04740233
5
04751232
2
04855497
2
04960787
2
04981866
2
05051508
4
05064862
2
05374724
2
05382584
18
05461157
2
05464863
5
05639905
3
05889021
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06103749
2
06355680
12
06579884
3
06646010
2
06924286
2
06958357
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07186726
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07449586
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08252875
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08481738
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08653553
2
08710234
2
08754092
4
08785665
6
08796294
2
JP4751836B2
4
JPS60208972A
2
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:02:20 UTC 2023
Edited
by admin
on Fri Dec 15 19:02:20 UTC 2023
Record UNII
695APM3L5Y
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
2,6-XYLIDINE HYDROCHLORIDE
Systematic Name English
ROPIVACAINE RELATED COMPOUND A [USP-RS]
Common Name English
BENZENAMINE, 2,6-DIMETHYL-, HYDROCHLORIDE (1:1)
Systematic Name English
LIDOCAINE HYDROCHLORIDE RELATED COMPOUND 2,6-DIMETHYLANILINE HYDROCHLORIDE [USP IMPURITY]
Common Name English
2,6-DIMETHYLANILINE HYDROCHLORIDE
Systematic Name English
BENZENAMINE, 2,6-DIMETHYL-, HYDROCHLORIDE
Systematic Name English
ROPIVACAINE RELATED COMPOUND A [USP IMPURITY]
Common Name English
ROPIVACAINE RELATED COMPOUND A
USP   USP-RS  
Common Name English
2,6-XYLIDINE, HYDROCHLORIDE
Systematic Name English
2,6-DIMETHYLBENZENAMINE HYDROCHLORIDE
Systematic Name English
Code System Code Type Description
CAS
21436-98-6
Created by admin on Fri Dec 15 19:02:20 UTC 2023 , Edited by admin on Fri Dec 15 19:02:20 UTC 2023
PRIMARY
EPA CompTox
DTXSID80175705
Created by admin on Fri Dec 15 19:02:20 UTC 2023 , Edited by admin on Fri Dec 15 19:02:20 UTC 2023
PRIMARY
RS_ITEM_NUM
1605512
Created by admin on Fri Dec 15 19:02:20 UTC 2023 , Edited by admin on Fri Dec 15 19:02:20 UTC 2023
PRIMARY
PUBCHEM
88899
Created by admin on Fri Dec 15 19:02:20 UTC 2023 , Edited by admin on Fri Dec 15 19:02:20 UTC 2023
PRIMARY
ECHA (EC/EINECS)
244-388-1
Created by admin on Fri Dec 15 19:02:20 UTC 2023 , Edited by admin on Fri Dec 15 19:02:20 UTC 2023
PRIMARY
FDA UNII
695APM3L5Y
Created by admin on Fri Dec 15 19:02:20 UTC 2023 , Edited by admin on Fri Dec 15 19:02:20 UTC 2023
PRIMARY
MESH
C007766
Created by admin on Fri Dec 15 19:02:20 UTC 2023 , Edited by admin on Fri Dec 15 19:02:20 UTC 2023
PRIMARY
Related Record Type Details
Structure of 2,6-XYLIDINE
PARENT -> SALT/SOLVATE
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