2,6-XYLIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H11N
Molecular Weight	121.1796
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=CC(C)=C1N

InChI

InChIKey=UFFBMTHBGFGIHF-UHFFFAOYSA-N

InChI=1S/C8H11N/c1-6-4-3-5-7(2)8(6)9/h3-5H,9H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C8H11N
Molecular Weight	121.1796
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Hepatic effects of xylidine isomers in rats.	1979 Jan	224531
Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure.	1993 Jul	8243401
An update of the National Toxicology Program database on nasal carcinogens.	1997 Oct 31	9385384
Determination of the levels of aromatic amines in indoor and outdoor air in Italy.	2001 Apr	11302581
Synthesis, characterization, and comparative 32P-postlabeling efficiencies of 2,6-dimethylaniline-DNA adducts.	2001 Feb	11258965
Oxidation of 2,6-dimethylaniline by recombinant human cytochrome P450s and human liver microsomes.	2001 Jun	11409937
Involvement of liver carboxylesterases in the in vitro metabolism of lidocaine.	2002 Jun	12019189
Asymmetric synthesis of axially chiral benzamides and anilides by enantiotopic lithiation of prochiral arene chromium complexes.	2002 Mar 22	11895413
Determination of 2,6-dimethylaniline and o-toluidine impurities in preparations for local anaesthesia by the HPLC method with amperometric detection.	2002 Sep-Oct	12602793
Update on olfactory mucosal metabolic enzymes: age-related changes and N-acetyltransferase activities.	2004	15452881
Synthesis, structure and pharmacology of acyl-2,6-xylidines.	2004 May-Jun	15481248
Metabolic activation of 2,6-xylidine in the nasal olfactory mucosa and the mucosa of the upper alimentary and respiratory tracts in rats.	2004 Oct	15254337
A kinetically controlled trans bifunctionalized organoimido derivative of the Lindqvist-type hexamolybdate: synthesis, spectroscopic characterization, and crystal structure of (n-Bu4N)2{trans-[Mo6O17(NAr)2]} (Ar = 2,6-dimethylphenyl).	2005 Dec 26	16363852
Primary amido substituted diborane4 compounds and imidodiborate4 anions.	2005 Oct 7	16172634
DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice.	2006 Aug	16918249
Production and characterization of laccase from Cyathus bulleri and its use in decolourization of recalcitrant textile dyes.	2006 Aug	16261367
Amine mediated proton transfer reaction and C-Cl bond activation of solvent chloroform by a trinuclear copper(II) complex of a glucopyranosylamine derived ligand.	2006 Aug 21	16883400
Pi-Pi complexation of bupivacaine and analogues with aromatic receptors: implications for overdose remediation.	2007	18019843
In vitro metabolism and interactions of the fungicide metalaxyl in human liver preparations.	2007 Jan	21783735
Assessment of the medicines lidocaine, prilocaine, and their metabolites, 2,6-dimethylaniline and 2-methylaniline, for DNA adduct formation in rat tissues.	2008 Aug	18490435
The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase.	2008 Dec 15	18977146
N-(2,6-Dimethyl-phen-yl)succinamic acid.	2009 Feb 6	21582137
Kinetics of 2,6-dimethylaniline degradation by electro-Fenton process.	2009 Jan 30	18554787
Ethyl 2-[(2,6-dimethyl-phen-yl)hydrazono]-3-oxobutanoate.	2009 Jun 10	21582829
N-[3-(2,6-Dimethylanilino)-1-methylbut-2-enylidene]-2,6-dimethylanilinium chloride.	2009 Jun 24	21582931
N-(2,6-Dimethyl-phen-yl)-2-(2-thien-yl)acetamide.	2009 Nov 25	21578912
Drug impurity profiling by capillary electrophoresis/mass spectrometry using various ionization techniques.	2009 Sep	19670338
N-(2,6-Dimethyl-phen-yl)-4-methyl-benzene-sulfonamide.	2010 Apr 24	21579210
N-(2,6-Dimethyl-phen-yl)succinimide.	2010 Jan 9	21579755

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:09:07 GMT 2023` Edited by `admin` on `Fri Dec 15 17:09:07 GMT 2023`
Record UNII	4FT62OX08D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2,6-XYLIDINE

Systematic Name

English

2,6-DIMETHYLANILINE [USP IMPURITY]

Common Name

English

2,6-DIMETHYLBENZENAMINE

Systematic Name

English

BUPIVACAINE HYDROCHLORIDE IMPURITY F [EP IMPURITY]

Common Name

English

XYLAZINE HYDROCHLORIDE IMPURITY A [EP IMPURITY]

Common Name

English

XYLIDENE, 2,6-

Common Name

English

2,6-DIMETHYLANILINE

Systematic Name

English

MEPIVACAINE HYDROCHLORIDE IMPURITY A [EP IMPURITY]

Common Name

English

XYLIDINE 2,6-DIMETHYLBENZENAMINE

Systematic Name

English

2,6-DIMETHYLANILINE [IARC]

Common Name

English

NCI-C56188

Code

English

LIDOCAINE IMPURITY A [EP IMPURITY]

Common Name

English

NSC-7098

Code

English

O-XYLIDINE

Common Name

English

ROPIVACAINE HYDROCHLORIDE MONOHYDRATE IMPURITY H [EP IMPURITY]

Common Name

English

2,6-XYLIDINE [HSDB]

Common Name

English

ROPIVACAINE RELATED COMPOUND A FREE BASE

Common Name

English

LIDOCAINE HYDROCHLORIDE IMPURITY A [EP IMPURITY]

Common Name

English

XYLIDINE 2,6-DIMETHYLBENZENAMINE [MI]

Common Name

English

2-AMINO-1,3-XYLENE

Systematic Name

English

BENZENAMINE, 2,6-DIMETHYL-

Systematic Name

English

LIDOCAINE RELATED COMPOUND 2,6-DIMETHYLANILINE [USP IMPURITY]

Common Name

English

1-AMINO-2,6-DIMETHYLBENZENE

Systematic Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

90502