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Details

Stereochemistry ACHIRAL
Molecular Formula C8H11N
Molecular Weight 121.1796
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 2,6-XYLIDINE

SMILES

CC1=CC=CC(C)=C1N

InChI

InChIKey=UFFBMTHBGFGIHF-UHFFFAOYSA-N
InChI=1S/C8H11N/c1-6-4-3-5-7(2)8(6)9/h3-5H,9H2,1-2H3

HIDE SMILES / InChI
Molecular Formula C8H11N
Molecular Weight 121.1796
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Hepatic effects of xylidine isomers in rats.
1979 Jan
Analysis of the lidocaine metabolite 2,6-dimethylaniline in bovine and human milk.
2001 Nov-Dec
Asymmetric synthesis of axially chiral benzamides and anilides by enantiotopic lithiation of prochiral arene chromium complexes.
2002 Mar 22
Identification of DNA adducts using HPLC/MS/MS following in vitro and in vivo experiments with arylamines and nitroarenes.
2003 Oct
Liquid phase overtone spectral investigations of 2,6-dimethylaniline and 2,4-dimethylaniline-evidence for steric nature of the ortho effect and the consequent base weakening.
2004 Aug
Determination of local anaesthetics and their impurities in pharmaceutical preparations using HPLC method with amperometric detection.
2005 Apr 29
Changes in production of lignin degrading enzymes during interactions between mycelia of the tropical decomposer basidiomycetes Marasmiellus troyanus and Marasmius pallescens.
2006 Feb
Synthesis, structure, and characterization of molybdenum(VI) imido complexes with N-salicylidene-2-aminophenol.
2006 Jul 10
Similarities and differences between azomethines and ketimines: synthesis, materials characterization and structure of novel imines compounds.
2007 Apr
Liquid-phase microextraction-gas chromatography-mass spectrometry for the determination of bromate, iodate, bromide and iodide in high-chloride matrix.
2007 May 4
Temperature investigations of E/Z isomers in ketimines based of p-dibenzoylobenzene with aniline and 2,6-dimethylaniline by infrared spectroscopy.
2007 Oct
N-(2,6-Dimethyl-phen-yl)benzene-sulfonamide.
2008 Aug 6
Quantitative mass spectrometric analysis of ropivacaine and bupivacaine in authentic, pharmaceutical and spiked human plasma without chromatographic separation.
2008 May 28
N-(2,6-Dimethyl-phen-yl)succinamic acid.
2009 Feb 6
Ethyl 2-[(2,6-dimethyl-phen-yl)hydrazono]-3-oxobutanoate.
2009 Jun 10
Mixed carbene-isocyanide Pd(II) complexes: synthesis, structures and reactivity towards nucleophiles.
2009 Mar 28
Third-order nonlinear optical properties and structures of (E)-N-(4-nitrobenzylidene)-2,6-dimethylaniline and (E)-N-(4-nitrobenzylidene)-2,3-dimethylaniline.
2010 May
Investigating the mechanisms of aromatic amine-induced protein free radical formation by quantitative structure-activity relationships: implications for drug-induced agranulocytosis.
2010 May 17
Patents

Patents

03966811
2
04034108
3
04046554
2
04147804
3
04188341
2
04203904
2
04243819
7
04275079
2
04291049
3
04411912
7
04740233
5
04751232
2
04855497
2
04960787
2
04981866
2
05051508
4
05064862
2
05374724
2
05382584
18
05461157
2
05464863
5
05639905
3
05889021
4
06103749
2
06355680
12
06579884
3
06646010
2
06924286
2
06958357
2
07186726
2
07449586
2
08252875
2
08481738
2
08653553
2
08710234
2
08754092
4
08785665
6
08796294
2
JP4751836B2
4
JPS60208972A
2
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:09:07 UTC 2023
Edited
by admin
on Fri Dec 15 17:09:07 UTC 2023
Record UNII
4FT62OX08D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
2,6-XYLIDINE
HSDB  
Systematic Name English
2,6-DIMETHYLANILINE [USP IMPURITY]
Common Name English
2,6-DIMETHYLBENZENAMINE
Systematic Name English
BUPIVACAINE HYDROCHLORIDE IMPURITY F [EP IMPURITY]
Common Name English
XYLAZINE HYDROCHLORIDE IMPURITY A [EP IMPURITY]
Common Name English
XYLIDENE, 2,6-
Common Name English
2,6-DIMETHYLANILINE
Systematic Name English
MEPIVACAINE HYDROCHLORIDE IMPURITY A [EP IMPURITY]
Common Name English
XYLIDINE 2,6-DIMETHYLBENZENAMINE
MI  
Systematic Name English
2,6-DIMETHYLANILINE [IARC]
Common Name English
NCI-C56188
Code English
LIDOCAINE IMPURITY A [EP IMPURITY]
Common Name English
NSC-7098
Code English
O-XYLIDINE
Common Name English
ROPIVACAINE HYDROCHLORIDE MONOHYDRATE IMPURITY H [EP IMPURITY]
Common Name English
2,6-XYLIDINE [HSDB]
Common Name English
ROPIVACAINE RELATED COMPOUND A FREE BASE
Common Name English
LIDOCAINE HYDROCHLORIDE IMPURITY A [EP IMPURITY]
Common Name English
XYLIDINE 2,6-DIMETHYLBENZENAMINE [MI]
Common Name English
2-AMINO-1,3-XYLENE
Systematic Name English
BENZENAMINE, 2,6-DIMETHYL-
Systematic Name English
LIDOCAINE RELATED COMPOUND 2,6-DIMETHYLANILINE [USP IMPURITY]
Common Name English
1-AMINO-2,6-DIMETHYLBENZENE
Systematic Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 90502
Created by admin on Fri Dec 15 17:09:07 UTC 2023 , Edited by admin on Fri Dec 15 17:09:07 UTC 2023
Code System Code Type Description
WIKIPEDIA
2,6-XYLIDINE
Created by admin on Fri Dec 15 17:09:07 UTC 2023 , Edited by admin on Fri Dec 15 17:09:07 UTC 2023
PRIMARY
EPA CompTox
DTXSID8026307
Created by admin on Fri Dec 15 17:09:07 UTC 2023 , Edited by admin on Fri Dec 15 17:09:07 UTC 2023
PRIMARY
FDA UNII
4FT62OX08D
Created by admin on Fri Dec 15 17:09:07 UTC 2023 , Edited by admin on Fri Dec 15 17:09:07 UTC 2023
PRIMARY
CAS
87-62-7
Created by admin on Fri Dec 15 17:09:07 UTC 2023 , Edited by admin on Fri Dec 15 17:09:07 UTC 2023
PRIMARY
CHEBI
28738
Created by admin on Fri Dec 15 17:09:07 UTC 2023 , Edited by admin on Fri Dec 15 17:09:07 UTC 2023
PRIMARY
MESH
C007766
Created by admin on Fri Dec 15 17:09:07 UTC 2023 , Edited by admin on Fri Dec 15 17:09:07 UTC 2023
PRIMARY
MERCK INDEX
m11552
Created by admin on Fri Dec 15 17:09:07 UTC 2023 , Edited by admin on Fri Dec 15 17:09:07 UTC 2023
PRIMARY Merck Index
NSC
7098
Created by admin on Fri Dec 15 17:09:07 UTC 2023 , Edited by admin on Fri Dec 15 17:09:07 UTC 2023
PRIMARY
PUBCHEM
6896
Created by admin on Fri Dec 15 17:09:07 UTC 2023 , Edited by admin on Fri Dec 15 17:09:07 UTC 2023
PRIMARY
ECHA (EC/EINECS)
201-758-7
Created by admin on Fri Dec 15 17:09:07 UTC 2023 , Edited by admin on Fri Dec 15 17:09:07 UTC 2023
PRIMARY
HSDB
2094
Created by admin on Fri Dec 15 17:09:07 UTC 2023 , Edited by admin on Fri Dec 15 17:09:07 UTC 2023
PRIMARY
Related Record Type Details
Structure of 2,6-XYLIDINE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of D-2624
PARENT -> METABOLITE
IN VITRO
Structure of LIDOCAINE
PARENT -> METABOLITE INACTIVE
has unknown pharmacologic activity but is carcinogenic in rats (http://srsid.fda.gov:9618/ePS/SubstanceRelationship.do?substanceMode=update&calledFrom=viewUpdateIngredient&RELATIONSHIP_ID=128538&SUBSTANCE_ID=1422&BDNUM=0021807AA).
PLASMA
Related Record Type Details
Structure of XYLAZINE HYDROCHLORIDE
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of LIDOCAINE
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of LIDOCAINE
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of BUPIVACAINE HYDROCHLORIDE
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of ROPIVACAINE HYDROCHLORIDE
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of XYLAZINE
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of MEPIVACAINE HYDROCHLORIDE
PARENT -> IMPURITY
color comparison
EP
Structure of LIDOCAINE HYDROCHLORIDE
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
NIH
NCATS
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