REBAUDIOSIDE E

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C44H70O23
Molecular Weight	967.0128
Optical Activity	UNSPECIFIED
Defined Stereocenters	26 / 26
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@]12CCC[C@](C)([C@H]1CC[C@@]34CC(=C)[C@@](C3)(CC[C@@H]24)O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C(=O)O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O

InChI

InChIKey=RLLCWNUIHGPAJY-SFUUMPFESA-N

InChI=1S/C44H70O23/c1-17-11-43-9-5-22-41(2,7-4-8-42(22,3)40(59)66-38-34(30(55)26(51)20(14-47)62-38)64-36-32(57)28(53)24(49)18(12-45)60-36)23(43)6-10-44(17,16-43)67-39-35(31(56)27(52)21(15-48)63-39)65-37-33(58)29(54)25(50)19(13-46)61-37/h18-39,45-58H,1,4-16H2,2-3H3/t18-,19-,20-,21-,22+,23+,24-,25-,26-,27-,28+,29+,30+,31+,32-,33-,34-,35-,36+,37+,38+,39+,41-,42-,43-,44+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C44H70O23
Molecular Weight	967.0128
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	26 / 26
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.google.com/patents/EP3010350A4 | http://www.internationalsteviacouncil.org/index.php?id=62 | http://www.freepatentsonline.com/y2016/0183574.html | http://epa.niif.hu/02200/02286/00015/pdf/EPA02286_European_Chemical_Bulletin_2013_05_298-302.pdf

Rebaudioside E is one of the associated glycosides found in the stevia plant. It is generally present in preparations of Steviol glycosides at levels lower than stevioside or Rebaudioside A. Food sweetener. Rebaudioside E is minor component of S. rebaudiana and tastes about 150-200 times sweeter than sucrose and is non-caloric.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
In vitro metabolism of rebaudioside E under anaerobic conditions: Comparison with rebaudioside A.	2015-08	26003514
Minor diterpene glycosides from the leaves of Stevia rebaudiana.	2014-05-23	24758242

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Steviol, steviolbioside, Reb A and Reb E (Rebaudioside E), were each dissolved in appropriate solvents to provide a set of 200 mg/mL spiking solutions. These solutions were further diluted 10 with their corresponding vehicle to provide another set of dosing solutions at a target concentration of 20 mg/mL. When spiked to the incubation samples (ie. a 100 dilution) it was anticipated that these solutions would result in the target testing concentrations of 2 mg/mL and 0.2 mg/mL, respectively. Reb E incubated at 0.2 mg/mL was also rapidly metabolized to steviol, with almost all converted to steviol after 16 h of incubation.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:08:51 GMT 2025` Edited by `admin` on `Mon Mar 31 22:08:51 GMT 2025`
Record UNII	693TGS3OHR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

REBAUDIOSIDE E

Common Name

English

FEMA NO. 4936

Preferred Name

English

REBAUDIOSIDE E [MI]

Common Name

English

KAUR-16-EN-18-OIC ACID, 13-((2-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)-, 2-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL ESTER, (4.ALPHA.)-

Common Name

English

(-)-REBAUDIOSIDE E

Common Name

English

Code System Code Type Description

MERCK INDEX

m9513