REBAUDIOSIDE E

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C44H70O23
Molecular Weight	967.0128
Optical Activity	UNSPECIFIED
Defined Stereocenters	26 / 26
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]8(O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(=O)[C@]2(C)CCC[C@@]3(C)[C@]4([H])CC[C@@]5(C[C@]4(CC5=C)CC[C@]23[H])O[C@]6([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O[C@]7([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O

InChI

InChIKey=RLLCWNUIHGPAJY-SFUUMPFESA-N

InChI=1S/C44H70O23/c1-17-11-43-9-5-22-41(2,7-4-8-42(22,3)40(59)66-38-34(30(55)26(51)20(14-47)62-38)64-36-32(57)28(53)24(49)18(12-45)60-36)23(43)6-10-44(17,16-43)67-39-35(31(56)27(52)21(15-48)63-39)65-37-33(58)29(54)25(50)19(13-46)61-37/h18-39,45-58H,1,4-16H2,2-3H3/t18-,19-,20-,21-,22+,23+,24-,25-,26-,27-,28+,29+,30+,31+,32-,33-,34-,35-,36+,37+,38+,39+,41-,42-,43-,44+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C44H70O23
Molecular Weight	967.0128
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	26 / 26
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.google.com/patents/EP3010350A4 | http://www.internationalsteviacouncil.org/index.php?id=62 | http://www.freepatentsonline.com/y2016/0183574.html | http://epa.niif.hu/02200/02286/00015/pdf/EPA02286_European_Chemical_Bulletin_2013_05_298-302.pdf

Rebaudioside E is one of the associated glycosides found in the stevia plant. It is generally present in preparations of Steviol glycosides at levels lower than stevioside or Rebaudioside A. Food sweetener. Rebaudioside E is minor component of S. rebaudiana and tastes about 150-200 times sweeter than sucrose and is non-caloric.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Minor diterpene glycosides from the leaves of Stevia rebaudiana.	2014 May 23	24758242
In vitro metabolism of rebaudioside E under anaerobic conditions: Comparison with rebaudioside A.	2015 Aug	26003514

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Steviol, steviolbioside, Reb A and Reb E (Rebaudioside E), were each dissolved in appropriate solvents to provide a set of 200 mg/mL spiking solutions. These solutions were further diluted 10 with their corresponding vehicle to provide another set of dosing solutions at a target concentration of 20 mg/mL. When spiked to the incubation samples (ie. a 100 dilution) it was anticipated that these solutions would result in the target testing concentrations of 2 mg/mL and 0.2 mg/mL, respectively. Reb E incubated at 0.2 mg/mL was also rapidly metabolized to steviol, with almost all converted to steviol after 16 h of incubation.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:31:54 GMT 2023` Edited by `admin` on `Sat Dec 16 08:31:54 GMT 2023`
Record UNII	693TGS3OHR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

REBAUDIOSIDE E

Common Name

English

REBAUDIOSIDE E [MI]

Common Name

English

FEMA NO. 4936

Code

English

KAUR-16-EN-18-OIC ACID, 13-((2-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)-, 2-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL ESTER, (4.ALPHA.)-

Common Name

English

(-)-REBAUDIOSIDE E

Common Name

English

Code System Code Type Description

MERCK INDEX

m9513