Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C8H9ClN2O2S |
| Molecular Weight | 232.687 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1NC2=C(C=C(Cl)C=C2)S(=O)(=O)N1
InChI
InChIKey=VZRNTCHTJRLTMU-UHFFFAOYSA-N
InChI=1S/C8H9ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-5,10-11H,1H3
| Molecular Formula | C8H9ClN2O2S |
| Molecular Weight | 232.687 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:47:07 GMT 2023
by
admin
on
Sat Dec 16 01:47:07 GMT 2023
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| Record UNII |
689UW7PT68
|
| Record Status |
Validated (UNII)
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| Record Version |
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IDRA-21
Created by
admin on Sat Dec 16 01:47:07 GMT 2023 , Edited by admin on Sat Dec 16 01:47:07 GMT 2023
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PRIMARY | IDRA-21 is an ampakine drug and a benzothiadiazine derivative. IDRA-21 is a chiral molecule, with (+)-IDRA-21 being the active form. IDRA-21 shows nootropic effects in animal studies, significantly improving learning and memory. It is around 1030 times more potent than aniracetam in reversing cognitive deficits induced by alprazolam or scopolamine,(2)(3) and produces sustained effects lasting for up to 48 hours after a single dose. The mechanism for this action is thought to be through promoting the induction of long-term potentiation between synapses in the brain. IDRA-21 does not produce neurotoxicity under normal conditions, although it may worsen neuronal damage following global ischemia after stroke or seizures. | ||
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22503-72-6
Created by
admin on Sat Dec 16 01:47:07 GMT 2023 , Edited by admin on Sat Dec 16 01:47:07 GMT 2023
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PRIMARY | |||
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689UW7PT68
Created by
admin on Sat Dec 16 01:47:07 GMT 2023 , Edited by admin on Sat Dec 16 01:47:07 GMT 2023
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PRIMARY | |||
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IDRA-21
Created by
admin on Sat Dec 16 01:47:07 GMT 2023 , Edited by admin on Sat Dec 16 01:47:07 GMT 2023
|
PRIMARY | IDRA-21 currently has only had animal trials. Dosing in a study with Patas Monkeys was 3 or 5.6 mg/kg p.o. in addition with 30 mg/kg p.o. of Aniracetam. This study indicated that IDRA-21 was 10-fold more potent than Aniracetam at reducing learning defects. A water maze study in rats showed cognitive enhancement at oral dosages of 4-120 mumol/kg. Human dosages have no history of peer-reviewed clinical studies. Some reading online suggested positive human activity at 5-25mg orally. | ||
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3688
Created by
admin on Sat Dec 16 01:47:07 GMT 2023 , Edited by admin on Sat Dec 16 01:47:07 GMT 2023
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ACTIVE MOIETY |
