U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Description
Sources: http://www.mfc.co.jp/english/eng/product/sanferol/pdf/fls_gras_notice.pdfhttps://mistralhowto.wordpress.com/2012/03/12/what-is-pigment-yellow-42-and-what-is-it-used-for/ | http://sensientfoodcolors.com/en-us/confection/iron-oxides-approved-by-the-fda/ | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=73.2250 | https://www.drugs.com/inactive/ferric-oxide-yellow-381.htmlhttps://books.google.ru/books?id=vxtxWneRBN4C&pg=PA1103&#v=onepage&q&f=falsehttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdfhttp://www.edta-chelate.com/ferric-ammonium-edta-liquid--1640836.htmlhttps://books.google.ru/books?id=3hLmyma2-MsC&pg=PA241&lpg=PA241&dq=FERRIC+AMMONIUM+CHLORIDE retrieved from A Consumer's Dictionary of Cosmetic Ingredients, 7th Edition: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics and Cosmeceuticals By Ruth Winterhttps://www.ncbi.nlm.nih.gov/pubmed/27995746 | http://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn01568/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=https://cameochemicals.noaa.gov/chemical/3468 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/27684194 | https://www.ncbi.nlm.nih.gov/pubmed/17511797 | https://www.ncbi.nlm.nih.gov/pubmed/1427505
Curator's Comment: description was created based on several sources, including https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol3/pdf/CFR-1996-title21-vol3-sec182-5375.pdf

Ferric chloride is a compound used as a food additive, a haemostatic or treatment for hypochromic anaemia. Ferric chloride induced vascular injury is a widely used model of occlusive thrombosis that reports platelet activation and aggregation in the context of an aseptic closed vascular system. Iron i.v. ferric chloride (960 mg) has being shown to be effective in correcting anaemia in HD patients with iron deficiency.

Originator

Monsanto Chemicals
44
Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1430
Chelating Agent
142
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Approved
8429
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8429
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Approved
8429
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

1998
Curative
Approved
8429
RADIOGARDASE

Approved Use

Insoluble Prussian blue is indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.

Launch Date

2003
Palliative
Approved
8429
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

2014
PubMed

PubMed

TitleDatePubMed
The formation of ferritin from apoferritin. Catalytic action of apoferritin.
1973 Oct
The absorption of iron as supplements in infant cereal and infant formulas.
1975 May
Biological availability of iron supplements for rats, chicks and humans.
1976 Feb
Non-invasive and non-destructive micro-XRF and micro-Raman analysis of a decorative wallpaper from the beginning of the 19th century.
2007 Feb
Heme Binding by Corynebacterium diphtheriae HmuT: Function and Heme Environment.
2015 Nov 3
Halide Influence on Molecular and Supramolecular Arrangements of Iron Complexes with a 3,5-Bis(2-Pyridyl)-1,2,4,6-Thiatriazine Ligand.
2016 Jun 6
A Simplified Fe-Based PhotoATRP Using Only Monomers and Solvent.
2017 Jul
Patents

Patents

20080188032
44
20090216060
44
6258758
44
US 5206265 A
44
US2385188
44
US3873678
44
US4364871
44
US6881255
44
US6903235
44
US7198668
44
US8071067
44

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Ferric sodium citrate is an additive used in various foods such as baby milk powder, school and hospital food, beverages, cereals and supplements. It is administered orally.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Polymer
Created
by admin
on Sat Dec 16 13:26:10 GMT 2023
Edited
by admin
on Sat Dec 16 13:26:10 GMT 2023
Record UNII
6897GXD6OE
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERRIC CARBOXYMALTOSE
INN   MART.   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN   INN  
Official Name English
POLYNUCLEAR IRON (III)-HYDROXIDE 4(R)-(POLY-(1->4)-O-.ALPHA.-D-GLUCOPYRANOSYL)-OXY-2(R),3(S),5(R), 6-TETRAHYDROXY-HEXANOATE
Common Name English
IRON(3+) HYDROXIDE OXIDE POLY-(1->4)-.ALPHA.-D-GLUCOPYRANOSYL-(1->4)-D-GLUCONATE HYDRATE
Common Name English
Ferric Carboxymaltose [WHO-DD]
Common Name English
FERRIC CARBOXYMALTOSE [ORANGE BOOK]
Common Name English
FERRIC CARBOXYMALTOSE [MART.]
Common Name English
ferric carboxymaltose [INN]
Common Name English
VIT-45
Code English
FERRIC CARBOXYMALTOSE [VANDF]
Common Name English
INJECTAFER
Brand Name English
FERRIC CARBOXYMALTOSE [JAN]
Common Name English
FERRIC CARBOXYMALTOSE [USAN]
Common Name English
IRON DEXTRI-MALTOSE
Common Name English
Code System Code Type Description
FDA UNII
6897GXD6OE
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
PRIMARY
ChEMBL
CHEMBL2108597
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
PRIMARY
CAS
1461680-64-7
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
PRIMARY
DRUG CENTRAL
5128
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
PRIMARY
USAN
SS-40
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
PRIMARY
RXCUI
1433693
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
PRIMARY RxNorm
SMS_ID
100000134826
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
PRIMARY
INN
8853
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
PRIMARY
CAS
9007-72-1
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
ALTERNATIVE
NCI_THESAURUS
C166915
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
PRIMARY
EVMPD
SUB66620
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
PRIMARY
DAILYMED
6897GXD6OE
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
PRIMARY
MESH
C522335
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
PRIMARY
PUBCHEM
86278165
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
PRIMARY
LACTMED
Ferric Carboxymaltose
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
PRIMARY
DRUG BANK
DB08917
Created by admin on Sat Dec 16 13:26:10 GMT 2023 , Edited by admin on Sat Dec 16 13:26:10 GMT 2023
PRIMARY
Display Structure of FERRIC CARBOXYMALTOSE
Related Record Type Details
Structure of FERRIC CATION
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:COMPLEX AVERAGE CHEMICAL
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966