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Details

Stereochemistry ABSOLUTE
Molecular Formula C14H19NO2.ClH
Molecular Weight 269.767
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LEVOFACETOPERANE HYDROCHLORIDE

SMILES

Cl.CC(=O)O[C@@H]([C@H]1CCCCN1)C2=CC=CC=C2

InChI

InChIKey=LDPSCUMJCVDWCB-DTPOWOMPSA-N
InChI=1S/C14H19NO2.ClH/c1-11(16)17-14(12-7-3-2-4-8-12)13-9-5-6-10-15-13;/h2-4,7-8,13-15H,5-6,9-10H2,1H3;1H/t13-,14-;/m1./s1

HIDE SMILES / InChI

Molecular Formula C14H19NO2
Molecular Weight 233.3062
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Levophacetoperane is a piperidine derivative. Levofacetoperane is a sympathomimetic central nervous system stimulant and is commonly used to treat depression. Levophacetoperane is also a known analeptic and is strongly linked to apnea reversal in dogs after a single intravenous injection.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
PubMed

PubMed

TitleDatePubMed
Isolation and detection of methylphenidate, phacetoperane and some other sympatomimetic central nervous stimulants with special reference to doping. I. Gas chromatographic detection procedure with electron capture detection for some secondary amines.
1975-03-26
[FOREIGN PSYCHOPHARMACOLOGICAL DRUGS: LEVOFACETOPERANE (8228 RP)].
1964-10-31
[Obesity in pregnancy. Trial of RP 8228. 1-Phenyl-1-(2-piperidyl)-1-acetoxymethane HCi. Threolevogyric form].
1963-01
[The present status of RP-8228 in psychiatric therapeutics. Apropos of 32 recent cases].
1962-10-28
[Clinical study of a new psychoactive drug in psychiatry, RP-8228 or threo-levo-1-phenyl-1-(2-piperidyl)-1-acetoxymethane HCl].
1962-04
The stimulating effect of RP 8228 on inactive psychiatric patients.
1961-11-01
[Clinical tests of the activity of RP 8228 (phacetoperane) in an oligophrenic child].
1960
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:55:56 GMT 2025
Edited
by admin
on Mon Mar 31 17:55:56 GMT 2025
Record UNII
67UU667C62
Record Status Validated (UNII)
Record Version
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Name Type Language
LEVOFACETOPERANE HYDROCHLORIDE
Common Name English
LEVOPHACETOPERANE HYDROCHLORIDE
MI  
Preferred Name English
LEVOPHACETOPERANE HYDROCHLORIDE [MI]
Common Name English
2-PIPERIDINEMETHANOL, .ALPHA.-PHENYL-, ACETATE (ESTER), HYDROCHLORIDE, (-)-
Common Name English
2-PIPERIDINEMETHANOL, .ALPHA.-PHENYL-, 2-ACETATE, HYDROCHLORIDE (1:1), (.ALPHA.R,2R)-
Common Name English
LIDEPRAN HYDROCHLORIDE
Common Name English
Code System Code Type Description
PUBCHEM
76957863
Created by admin on Mon Mar 31 17:55:56 GMT 2025 , Edited by admin on Mon Mar 31 17:55:56 GMT 2025
PRIMARY
CAS
23257-56-9
Created by admin on Mon Mar 31 17:55:56 GMT 2025 , Edited by admin on Mon Mar 31 17:55:56 GMT 2025
PRIMARY
MERCK INDEX
m6791
Created by admin on Mon Mar 31 17:55:56 GMT 2025 , Edited by admin on Mon Mar 31 17:55:56 GMT 2025
PRIMARY Merck Index
EPA CompTox
DTXSID20945949
Created by admin on Mon Mar 31 17:55:56 GMT 2025 , Edited by admin on Mon Mar 31 17:55:56 GMT 2025
PRIMARY
ECHA (EC/EINECS)
245-536-8
Created by admin on Mon Mar 31 17:55:56 GMT 2025 , Edited by admin on Mon Mar 31 17:55:56 GMT 2025
PRIMARY
FDA UNII
67UU667C62
Created by admin on Mon Mar 31 17:55:56 GMT 2025 , Edited by admin on Mon Mar 31 17:55:56 GMT 2025
PRIMARY
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PARENT -> SALT/SOLVATE
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ACTIVE MOIETY