LEVOFACETOPERANE HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C14H19NO2.ClH
Molecular Weight	269.767
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of LEVOFACETOPERANE HYDROCHLORIDE

Structure Search

SMILES

Cl.[H][C@@]1(CCCCN1)[C@H](OC(C)=O)C2=CC=CC=C2

InChI

InChIKey=LDPSCUMJCVDWCB-DTPOWOMPSA-N

InChI=1S/C14H19NO2.ClH/c1-11(16)17-14(12-7-3-2-4-8-12)13-9-5-6-10-15-13;/h2-4,7-8,13-15H,5-6,9-10H2,1H3;1H/t13-,14-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C14H19NO2
Molecular Weight	233.3062
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.medkoo.com/products/26098 | https://www.ncbi.nlm.nih.gov/pubmed/239015 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 969, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Levophacetoperane is a piperidine derivative. Levofacetoperane is a sympathomimetic central nervous system stimulant and is commonly used to treat depression. Levophacetoperane is also a known analeptic and is strongly linked to apnea reversal in dogs after a single intravenous injection.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
norepinephrine uptake 18 Target ID: GO:0051620 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29714	Inhibitor 8297
dopamine uptake 14 Target ID: GO:0090494 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29714	Inhibitor 8297

PubMed

Title	Date	PubMed
[Clinical tests of the activity of RP 8228 (phacetoperane) in an oligophrenic child].	1960	13797965
The stimulating effect of RP 8228 on inactive psychiatric patients.	1961 Nov-Dec	13864565
[Clinical study of a new psychoactive drug in psychiatry, RP-8228 or threo-levo-1-phenyl-1-(2-piperidyl)-1-acetoxymethane HCl].	1962 Apr	13913515
[The present status of RP-8228 in psychiatric therapeutics. Apropos of 32 recent cases].	1962 Oct 28	13951512
[Obesity in pregnancy. Trial of RP 8228. 1-Phenyl-1-(2-piperidyl)-1-acetoxymethane HCi. Threolevogyric form].	1963 Jan	14015305
[FOREIGN PSYCHOPHARMACOLOGICAL DRUGS: LEVOFACETOPERANE (8228 RP)].	1964 Oct 31	14231300

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:23:10 GMT 2023` Edited by `admin` on `Fri Dec 15 15:23:10 GMT 2023`
Record UNII	67UU667C62
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LEVOFACETOPERANE HYDROCHLORIDE

Common Name

English

LEVOPHACETOPERANE HYDROCHLORIDE [MI]

Common Name

English

2-PIPERIDINEMETHANOL, .ALPHA.-PHENYL-, ACETATE (ESTER), HYDROCHLORIDE, (-)-

Common Name

English

LEVOPHACETOPERANE HYDROCHLORIDE

Common Name

English

2-PIPERIDINEMETHANOL, .ALPHA.-PHENYL-, 2-ACETATE, HYDROCHLORIDE (1:1), (.ALPHA.R,2R)-

Common Name

English

LIDEPRAN HYDROCHLORIDE

Common Name

English

Code System Code Type Description

PUBCHEM

76957863