Satricabtagene Autoleucel

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 14:02:03 GMT 2025` Edited by `admin` on `Wed Apr 02 14:02:03 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cell
Fraction Name	t lymphocytes
Record UNII	67B9LP62ET
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CAR-CLDN18.2 T Cells

Preferred Name

English

Satricabtagene Autoleucel

Official Name

English

SATRICABTAGENE AUTOLEUCEL [USAN]

Common Name

English

CT041

Code

English

CT-041

Code

English

satricabtagene autoleucel [INN]

Common Name

English

autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector, encoding a chimeric antigen receptor (CAR) targeting human claudin 18.2 (also known as cla

Common Name

English

Code System Code Type Description

INN

12215

Created by admin on Wed Apr 02 14:02:03 GMT 2025 , Edited by admin on Wed Apr 02 14:02:03 GMT 2025

PRIMARY

NCI_THESAURUS

C150382

Created by admin on Wed Apr 02 14:02:03 GMT 2025 , Edited by admin on Wed Apr 02 14:02:03 GMT 2025

PRIMARY

FDA UNII

67B9LP62ET

Created by admin on Wed Apr 02 14:02:03 GMT 2025 , Edited by admin on Wed Apr 02 14:02:03 GMT 2025

PRIMARY

USAN

MN-103

Created by admin on Wed Apr 02 14:02:03 GMT 2025 , Edited by admin on Wed Apr 02 14:02:03 GMT 2025

PRIMARY

SMS_ID

300000026033

Created by admin on Wed Apr 02 14:02:03 GMT 2025 , Edited by admin on Wed Apr 02 14:02:03 GMT 2025

PRIMARY

Related Record Type Details


					O86SW5D7BQ

CLAUDIN 18 SPLICE VARIANT 2

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					67B9LP62ET

Satricabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL		Satricabtagene autoleucel lentiviral vector	8TQ83W598K
CULTURE	ACTIVATOR	BIOLOGICAL		ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS	PA28ZKP50M
CULTURE	EXPANSION	BIOLOGICAL		HUMAN INTERLEUKIN-2	FNO32LO217

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					Satricabtagene autoleucel CAR-T receptor	M4K5SHK9L2
INSERTED GENE EXPRESSION VECTOR					Satricabtagene autoleucel transgene insert	SU4E6EK3MX

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ENHANCED ACTIVATION	BIOLOGICAL		`P050J5FWC5` INTERFERON GAMMA