U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 19:12:21 GMT 2023
Edited
by admin
on Sat Dec 16 19:12:21 GMT 2023
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials State LIVE GENETICALLY MODIFIED
Source Materials Parent
Part BLOOD
Fraction Material Type CELL
Fraction Name T lymphocytes
Record UNII
67B9LP62ET
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Satricabtagene Autoleucel
INN  
Official Name English
satricabtagene autoleucel [INN]
Common Name English
autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector, encoding a chimeric antigen receptor (CAR) targeting human claudin 18.2 (also known as cla
Common Name English
Code System Code Type Description
INN
12215
Created by admin on Sat Dec 16 19:12:21 GMT 2023 , Edited by admin on Sat Dec 16 19:12:21 GMT 2023
PRIMARY
FDA UNII
67B9LP62ET
Created by admin on Sat Dec 16 19:12:21 GMT 2023 , Edited by admin on Sat Dec 16 19:12:21 GMT 2023
PRIMARY
Related Record Type Details
TARGET->CYTOTOXIC T-CELL
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
LENTIVIRAL TRANSFECTION TRANSFECTION BIOLOGICAL Satricabtagene autoleucel lentiviral vector 8TQ83W598K
CULTURE ACTIVATOR BIOLOGICAL UNSPECIFIED SUBSTANCE 4e4ac683
CULTURE EXPANSION BIOLOGICAL HUMAN INTERLEUKIN-2 FNO32LO217

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN Satricabtagene autoleucel CAR-T receptor M4K5SHK9L2
INSERTED GENE EXPRESSION VECTOR Satricabtagene autoleucel transgene insert SU4E6EK3MX
Name Property Type Amount Referenced Substance Defining Parameters References
ENHANCED ACTIVATION BIOLOGICAL