Satricabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 19:12:21 GMT 2023` Edited by `admin` on `Sat Dec 16 19:12:21 GMT 2023`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Material Type	CELL
Fraction Name	T lymphocytes
Record UNII	67B9LP62ET
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Satricabtagene Autoleucel

Official Name

English

satricabtagene autoleucel [INN]

Common Name

English

autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector, encoding a chimeric antigen receptor (CAR) targeting human claudin 18.2 (also known as cla

Common Name

English

Code System Code Type Description

INN

12215

Created by admin on Sat Dec 16 19:12:21 GMT 2023 , Edited by admin on Sat Dec 16 19:12:21 GMT 2023

PRIMARY

FDA UNII

67B9LP62ET

Created by admin on Sat Dec 16 19:12:21 GMT 2023 , Edited by admin on Sat Dec 16 19:12:21 GMT 2023

PRIMARY

Related Record Type Details


					O86SW5D7BQ

CLAUDIN 18 SPLICE VARIANT 2

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					67B9LP62ET

Satricabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL	Satricabtagene autoleucel lentiviral vector	8TQ83W598K
CULTURE	ACTIVATOR	BIOLOGICAL	UNSPECIFIED SUBSTANCE	4e4ac683
CULTURE	EXPANSION	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					Satricabtagene autoleucel CAR-T receptor	M4K5SHK9L2
INSERTED GENE EXPRESSION VECTOR					Satricabtagene autoleucel transgene insert	SU4E6EK3MX

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ENHANCED ACTIVATION	BIOLOGICAL		`P050J5FWC5` INTERFERON GAMMA