Reflocibart

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 15:25:52 GMT 2023` Edited by `admin` on `Sat Dec 16 15:25:52 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	67AB88J6KN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Reflocibart

Official Name

English

Gamma4 heavy chain humanized(1-447) [VH (Homo sapiens IGHV1-2*06 (88.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120)-Homo sapiens IGHG4*01,nG4m(a) CH2 L92, G4v5 h P10 (CH1 (121-218), hinge 1-12 S10>P (228) (219-230), CH2 L92

Common Name

English

CSL-346

Common Name

English

Immunoglobulin G4 [228-proline], anti-(human vascular endothelial growth factor B) (human-Mus musculus monoclonal CSL346 γ4-chain), disulfide with human-Mus musculus monoclonal CSL346 κ-chain, dimer

Common Name

English

reflocibart [INN]

Common Name

English

CSL346

Common Name

English

Immunoglobulin G4-kappa, anti-[Homo sapiens VEGFB (vascular endothelial growth factor B)], humanized monoclonal antibody

Common Name

English

Code System Code Type Description

INN

12770

Created by admin on Sat Dec 16 15:25:52 GMT 2023 , Edited by admin on Sat Dec 16 15:25:52 GMT 2023

PRIMARY

CAS

2642578-92-3

Created by admin on Sat Dec 16 15:25:52 GMT 2023 , Edited by admin on Sat Dec 16 15:25:52 GMT 2023

PRIMARY

FDA UNII

67AB88J6KN

Created by admin on Sat Dec 16 15:25:52 GMT 2023 , Edited by admin on Sat Dec 16 15:25:52 GMT 2023

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_134	4_214
2_147	2_203
2_261	2_321
1_134	3_214
2_367	2_425
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_147	1_203
1_226	2_226
1_229	2_229
1_261	1_321
1_367	1_425

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_297
N	2_297

Related Record Type Details


					67AB88J6KN

Reflocibart

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL