Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C27H28INO10 |
| Molecular Weight | 653.4164 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1(C[C@H](N)[C@H](I)[C@H](C)O1)O[C@H]2C[C@@](O)(CC3=C(O)C4=C(C(=O)C5=C(OC)C=CC=C5C4=O)C(O)=C23)C(=O)CO
InChI
InChIKey=PDQGEKGUTOTUNV-TZSSRYMLSA-N
InChI=1S/C27H28INO10/c1-10-22(28)13(29)6-17(38-10)39-15-8-27(36,16(31)9-30)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,30,33,35-36H,6-9,29H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1
| Molecular Formula | C27H28INO10 |
| Molecular Weight | 653.4164 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Iododoxorubicin is an anthracycline derivative patented by Farmitalia Carlo Erba S.p.A. for cancer treatment. In preclinical studies, Iododoxorubicin has demonstrated significantly reduced levels of cardiotoxicity compared to anthracyclines. Unfortunately, during phase II clinical trials Iododoxorubicin failed to demonstrate efficacy in an advanced breast cancer patient
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Chemical and biological characterization of 4'-iodo-4'-deoxydoxorubicin. | 1987 Aug 1 |
|
| Phase II study of 4'-iodo-4'-deoxydoxorubicin in non-resectable non-small-cell lung cancer. | 1993 |
|
| [Advances in diagnosis and treatment of AL amyloidosis]. | 2008 Apr |
|
| A camelid anti-PrP antibody abrogates PrP replication in prion-permissive neuroblastoma cell lines. | 2010 Mar 22 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:44:07 GMT 2023
by
admin
on
Fri Dec 15 15:44:07 GMT 2023
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| Record UNII |
65JH75I9JX
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| Record Status |
Validated (UNII)
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| Record Version |
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| Name | Type | Language | ||
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Common Name | English | ||
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Common Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C1594
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admin on Fri Dec 15 15:44:07 GMT 2023 , Edited by admin on Fri Dec 15 15:44:07 GMT 2023
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108161
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65JH75I9JX
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DTXSID301004258
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100000126382
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83997-75-5
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SUB33288
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C971
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47897
Created by
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PRIMARY |
| Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
