TIQUIZIUM BROMIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H24NS2.Br
Molecular Weight	410.435
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Br-].[H][C@]12CCCC[N@+]1(C)CC(CC2)=C(C3=CC=CS3)C4=CC=CS4

InChI

InChIKey=VKBNGRDAHSELMQ-KYSFMIDTSA-M

InChI=1S/C19H24NS2.BrH/c1-20-11-3-2-6-16(20)10-9-15(14-20)19(17-7-4-12-21-17)18-8-5-13-22-18;/h4-5,7-8,12-13,16H,2-3,6,9-11,14H2,1H3;1H/q+1;/p-1/t16-,20-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	BrH
Molecular Weight	80.912
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C19H24NS2
Molecular Weight	330.531
Charge	1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	1 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8839659 | http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=2247

Tiquizium is an antispasmodic agent used to treat disorders of the gastrointestinal, biliary, and urinary systems. Tiquizium is available commercially in Japan for the treatment of gastrointestinal disease. Tiquizium shows anti-muscarinic action to improve convulsion and hypermobility of intestinal smooth muscle. It is usually used to treat convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Muscarinic acetylcholine receptor M1 169 Target ID: CHEMBL216 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10374898 \| https://www.ncbi.nlm.nih.gov/pubmed/8839659 \| https://www.ncbi.nlm.nih.gov/pubmed/3656779	Antagonist 2778	4.1 nM [Ki]
Muscarinic acetylcholine receptor M2 121 Target ID: CHEMBL211 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10374898 \| https://www.ncbi.nlm.nih.gov/pubmed/8839659 \| https://www.ncbi.nlm.nih.gov/pubmed/3656779	Antagonist 2778	4.0 nM [Ki]
Muscarinic acetylcholine receptor M3 159 Target ID: CHEMBL245 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10374898 \| https://www.ncbi.nlm.nih.gov/pubmed/8839659 \| https://www.ncbi.nlm.nih.gov/pubmed/3656779	Antagonist 2778	2.8 nM [Ki]
Muscarinic acetylcholine receptor M4 86 Target ID: CHEMBL1821 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10374898 \| https://www.ncbi.nlm.nih.gov/pubmed/8839659 \| https://www.ncbi.nlm.nih.gov/pubmed/3656779	Antagonist 2778	3.6 nM [Ki]
Muscarinic acetylcholine receptor M5 62 Target ID: CHEMBL2035 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10374898 \| https://www.ncbi.nlm.nih.gov/pubmed/8839659 \| https://www.ncbi.nlm.nih.gov/pubmed/3656779	Antagonist 2778	8.2 nM [Ki]

Conditions

Condition	Modality	Highest Phase	Product
Gastritis 45 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2895054	Primary	Approved 8429	Thiaton Approved Use Thiaton is usually used to treat convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis.
Gastric ulcer 67 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2895054 https://www.ncbi.nlm.nih.gov/pubmed/2895053	Primary	Approved 8429	Thiaton Approved Use Thiaton is usually used to treat convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis.
Urolithiasis 3 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=2247	Primary	Approved 8429	Thiaton Approved Use Thiaton is usually used to treat convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis.
Irritable bowel syndrome 60 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=2247	Primary	Approved 8429	Thiaton Approved Use Thiaton is usually used to treat convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis.
Biliary tract diseases 11 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=2247	Primary	Approved 8429	Thiaton Approved Use Thiaton is usually used to treat convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis.

PubMed

Title	Date	PubMed
Pharmacological profile of ramosetron, a novel therapeutic agent for IBS.	2007 Feb	17323187
Inhibitory effects of ramosetron, a potent and selective 5-HT3-receptor antagonist, on conditioned fear stress-induced abnormal defecation and normal defecation in rats: comparative studies with antidiarrheal and spasmolytic agents.	2008 Feb	18296863
Effects of serotonin 5-HT3 receptor antagonists on stress-induced colonic hyperalgesia and diarrhoea in rats: a comparative study with opioid receptor agonists, a muscarinic receptor antagonist and a synthetic polymer.	2008 May	18221252
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010 Dec	21818443

Patents

Sample Use Guides

In Vivo Use Guide

In general, for adults, take 5 to 10 mg of the active ingredient at a time, three times a day. The dosage may be adjusted according to the age and symptoms. This preparation contains 10 mg of the active ingredient in a capsule.

Route of Administration: Oral

In Vitro Use Guide

Tiquizium (1 x 10(-6) - 1x10(-5)g/ml) increased transmural stimulation (TM contraction) and/or resting tone (1 x 10(-5)g/ml) in isolated guinea pig urinary bladder.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:53:50 GMT 2023` Edited by `admin` on `Fri Dec 15 16:53:50 GMT 2023`
Record UNII	659K6049SF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TIQUIZIUM BROMIDE

Official Name

English

TRANS-3-(DI-2-THIENYLMETHYLENE)OCTAHYDRO-5-METHYL-2H-QUINOLIZINIUM BROMIDE

Systematic Name

English

tiquizium bromide [INN]

Common Name

English

TIQUIZIUM BROMIDE [MI]

Common Name

English

(±)-TRANS-3-(DI-2-THIENYLMETHYLENE)OCTAHYDRO-5-METHYL-2H-QUINOLIZINIUM BROMIDE

Systematic Name

English

THIATON

Brand Name

English

TIQUIZIUM BROMIDE [JAN]

Common Name

English

TIQUIZIUM BROMIDE [MART.]

Common Name

English

Tiquizium bromide [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29704