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Details

Stereochemistry RACEMIC
Molecular Formula C19H24NS2.Br
Molecular Weight 410.435
Optical Activity ( + / - )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TIQUIZIUM BROMIDE

SMILES

[Br-].[H][C@]12CCCC[N@+]1(C)CC(CC2)=C(C3=CC=CS3)C4=CC=CS4

InChI

InChIKey=VKBNGRDAHSELMQ-KYSFMIDTSA-M
InChI=1S/C19H24NS2.BrH/c1-20-11-3-2-6-16(20)10-9-15(14-20)19(17-7-4-12-21-17)18-8-5-13-22-18;/h4-5,7-8,12-13,16H,2-3,6,9-11,14H2,1H3;1H/q+1;/p-1/t16-,20-;/m1./s1

HIDE SMILES / InChI

Molecular Formula BrH
Molecular Weight 80.912
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C19H24NS2
Molecular Weight 330.531
Charge 1
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 1 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Tiquizium is an antispasmodic agent used to treat disorders of the gastrointestinal, biliary, and urinary systems. Tiquizium is available commercially in Japan for the treatment of gastrointestinal disease. Tiquizium shows anti-muscarinic action to improve convulsion and hypermobility of intestinal smooth muscle. It is usually used to treat convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Thiaton

Approved Use

Thiaton is usually used to treat convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis.
Primary
Thiaton

Approved Use

Thiaton is usually used to treat convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis.
Primary
Thiaton

Approved Use

Thiaton is usually used to treat convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis.
Primary
Thiaton

Approved Use

Thiaton is usually used to treat convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis.
Primary
Thiaton

Approved Use

Thiaton is usually used to treat convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis.
PubMed

PubMed

TitleDatePubMed
Pharmacological profile of ramosetron, a novel therapeutic agent for IBS.
2007 Feb
Inhibitory effects of ramosetron, a potent and selective 5-HT3-receptor antagonist, on conditioned fear stress-induced abnormal defecation and normal defecation in rats: comparative studies with antidiarrheal and spasmolytic agents.
2008 Feb
Effects of serotonin 5-HT3 receptor antagonists on stress-induced colonic hyperalgesia and diarrhoea in rats: a comparative study with opioid receptor agonists, a muscarinic receptor antagonist and a synthetic polymer.
2008 May
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Patents

Sample Use Guides

In general, for adults, take 5 to 10 mg of the active ingredient at a time, three times a day. The dosage may be adjusted according to the age and symptoms. This preparation contains 10 mg of the active ingredient in a capsule.
Route of Administration: Oral
In Vitro Use Guide
Tiquizium (1 x 10(-6) - 1x10(-5)g/ml) increased transmural stimulation (TM contraction) and/or resting tone (1 x 10(-5)g/ml) in isolated guinea pig urinary bladder.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:53:50 GMT 2023
Edited
by admin
on Fri Dec 15 16:53:50 GMT 2023
Record UNII
659K6049SF
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TIQUIZIUM BROMIDE
INN   JAN   MART.   MI   WHO-DD  
INN  
Official Name English
TRANS-3-(DI-2-THIENYLMETHYLENE)OCTAHYDRO-5-METHYL-2H-QUINOLIZINIUM BROMIDE
Systematic Name English
tiquizium bromide [INN]
Common Name English
TIQUIZIUM BROMIDE [MI]
Common Name English
(±)-TRANS-3-(DI-2-THIENYLMETHYLENE)OCTAHYDRO-5-METHYL-2H-QUINOLIZINIUM BROMIDE
Systematic Name English
THIATON
Brand Name English
TIQUIZIUM BROMIDE [JAN]
Common Name English
TIQUIZIUM BROMIDE [MART.]
Common Name English
Tiquizium bromide [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29704
Created by admin on Fri Dec 15 16:53:50 GMT 2023 , Edited by admin on Fri Dec 15 16:53:50 GMT 2023
Code System Code Type Description
CAS
71731-58-3
Created by admin on Fri Dec 15 16:53:50 GMT 2023 , Edited by admin on Fri Dec 15 16:53:50 GMT 2023
PRIMARY
PUBCHEM
72159
Created by admin on Fri Dec 15 16:53:50 GMT 2023 , Edited by admin on Fri Dec 15 16:53:50 GMT 2023
PRIMARY
MERCK INDEX
m10886
Created by admin on Fri Dec 15 16:53:50 GMT 2023 , Edited by admin on Fri Dec 15 16:53:50 GMT 2023
PRIMARY Merck Index
EPA CompTox
DTXSID2046757
Created by admin on Fri Dec 15 16:53:50 GMT 2023 , Edited by admin on Fri Dec 15 16:53:50 GMT 2023
PRIMARY
ChEMBL
CHEMBL1872078
Created by admin on Fri Dec 15 16:53:50 GMT 2023 , Edited by admin on Fri Dec 15 16:53:50 GMT 2023
PRIMARY
INN
5190
Created by admin on Fri Dec 15 16:53:50 GMT 2023 , Edited by admin on Fri Dec 15 16:53:50 GMT 2023
PRIMARY
FDA UNII
659K6049SF
Created by admin on Fri Dec 15 16:53:50 GMT 2023 , Edited by admin on Fri Dec 15 16:53:50 GMT 2023
PRIMARY
EVMPD
SUB11113MIG
Created by admin on Fri Dec 15 16:53:50 GMT 2023 , Edited by admin on Fri Dec 15 16:53:50 GMT 2023
PRIMARY
SMS_ID
100000077246
Created by admin on Fri Dec 15 16:53:50 GMT 2023 , Edited by admin on Fri Dec 15 16:53:50 GMT 2023
PRIMARY
NCI_THESAURUS
C90744
Created by admin on Fri Dec 15 16:53:50 GMT 2023 , Edited by admin on Fri Dec 15 16:53:50 GMT 2023
PRIMARY
CHEBI
32232
Created by admin on Fri Dec 15 16:53:50 GMT 2023 , Edited by admin on Fri Dec 15 16:53:50 GMT 2023
PRIMARY
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