TANTALUM

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	Ta
Molecular Weight	180.94788
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Ta]

InChI

InChIKey=GUVRBAGPIYLISA-UHFFFAOYSA-N

InChI=1S/Ta

HIDE SMILES / InChI

Molecular Formula	Ta
Molecular Weight	180.94788
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/30468450 | https://www.ncbi.nlm.nih.gov/pubmed/30458456 | https://www.lenntech.com/periodic/elements/ta.htm

Tantalum (Ta) possesses osteoinductivity that was studied in healthy subjects. It is known that the integrin α5β1/ERK1/2 pathway plays a crucial role in regulating rat bone mesenchymal stromal cells (rBMSCs) osteogenic differentiation. Thus, the greater ability of a Ta surface to trigger integrin α5β1/ERK1/2 signaling could explain its better osteoinductivity. Besides, there are no reports of adverse health effects of Ta in industrially exposed workers. In contact with tissue, metallic tantalum is inert.

Approval Year

PubMed

Title	Date	PubMed
Osteoinductive effects of tantalum and titanium on bone mesenchymal stromal cells and bone formation in ovariectomized rats.	2018-11	30468450
Intrinsic Surface Effects of Tantalum and Titanium on Integrin α5β1/ ERK1/2 Pathway-Mediated Osteogenic Differentiation in Rat Bone Mesenchymal Stromal Cells.	2018	30458456

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:33:20 GMT 2025` Edited by `admin` on `Mon Mar 31 18:33:20 GMT 2025`
Record UNII	6424HBN274
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TA

Preferred Name

English

TANTALUM

Systematic Name

English

TANTALUM [MI]

Common Name

English

TANTALUM [HSDB]

Common Name

English

TANTALUM, ELEMENTAL

Common Name

English

Classification Tree Code System Code

DSLD

2059 (Number of products:28)