Tantalum (Ta) possesses osteoinductivity that was studied in healthy subjects. It is known that the integrin α5β1/ERK1/2 pathway plays a crucial role in regulating rat bone mesenchymal stromal cells (rBMSCs) osteogenic differentiation. Thus, the greater ability of a Ta surface to trigger integrin α5β1/ERK1/2 signaling could explain its better osteoinductivity. Besides, there are no reports of adverse health effects of Ta in industrially exposed workers. In contact with tissue, metallic tantalum is inert.