U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 14:42:21 GMT 2023
Edited
by admin
on Sat Dec 16 14:42:21 GMT 2023
Source Materials Class ORGANISM
Source Materials Type RECOMBINANT VIRUS
Source Materials State LIVE NON-REPLICATING GENETICALLY MODIFIED
Organism Family Parvoviridae
Organism Genus Dependovirus
Organism Species adeno-associated virus
Author NONE
Infraspecific Type SUBSTRAIN
Infraspecific Name AAV2(ITR)/AAV1, 2, 3B, 4, 5, 6 8, 9, AVIAN AND BOVINE AAV(PALSMID) FOLLOWED BY IN VIVOSELECTION IN FAH//RAG2//IL2RG/ (FRG) MICE PARTIALLY REPOPULATED WITH HUMAN HEPATOCYTES/HUMAN B-DOMAIN-DELETED BLOOD COAGULATION FACTOR VIII/TTRM/VECTOR (INTRONLESS)
Part WHOLE
Record UNII
63QD0BX9B4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ROVOCTOCOGENE DURPARVOVEC
INN  
Official Name English
A RECOMBINANT INTRONLESS NON-REPLICATING ADENO-ASSOCIATED VIRUS 2 VECTOR (AAV2) WITH A BIO-ENGINEERED CAPSID DERIVED BY DNA SHUFFLING OF 10 AAV CAPSID SEQUENCES (AAV1, 2, 3B, 4, 5, 6 8, 9, AVIAN AND BOVINE AAV) FOLLOWED BY IN VIVO SELECTION IN FAH//RAG2/
Systematic Name English
rovoctocogene durparvovec [INN]
Common Name English
Code System Code Type Description
FDA UNII
63QD0BX9B4
Created by admin on Sat Dec 16 14:42:21 GMT 2023 , Edited by admin on Sat Dec 16 14:42:21 GMT 2023
PRIMARY
NCI_THESAURUS
C175201
Created by admin on Sat Dec 16 14:42:21 GMT 2023 , Edited by admin on Sat Dec 16 14:42:21 GMT 2023
PRIMARY
INN
10992
Created by admin on Sat Dec 16 14:42:21 GMT 2023 , Edited by admin on Sat Dec 16 14:42:21 GMT 2023
PRIMARY
CAS
2163074-26-6
Created by admin on Sat Dec 16 14:42:21 GMT 2023 , Edited by admin on Sat Dec 16 14:42:21 GMT 2023
PRIMARY
Related Record Type Details
TARGET->ENZYME REPLACEMENT
DERIVATIVE -> PARENT
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
GENE_EXPRESSION VECTOR ROVOCTOCOGENE DURPARVOVEC TRANSGENE INSERT UI9IU8M1ME