MEPINDOLOL SULFATE

Details

Stereochemistry	RACEMIC
Molecular Formula	2C15H22N2O2.H2O4S
Molecular Weight	622.773
Optical Activity	( + / - )
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OS(O)(=O)=O.CC(C)NCC(O)COC1=CC=CC2=C1C=C(C)N2.CC(C)NCC(O)COC3=CC=CC4=C3C=C(C)N4

InChI

InChIKey=PNYFXKOIFMZVQC-UHFFFAOYSA-N

InChI=1S/2C15H22N2O2.H2O4S/c2*1-10(2)16-8-12(18)9-19-15-6-4-5-14-13(15)7-11(3)17-14;1-5(2,3)4/h2*4-7,10,12,16-18H,8-9H2,1-3H3;(H2,1,2,3,4)

HIDE SMILES / InChI

Molecular Formula	H2O4S
Molecular Weight	98.078
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C15H22N2O2
Molecular Weight	262.3474
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2846947 | https://www.ncbi.nlm.nih.gov/pubmed/3759280 | https://www.ncbi.nlm.nih.gov/pubmed/343414 | https://www.ncbi.nlm.nih.gov/pubmed/2859251 | https://www.drugfuture.com/chemdata/mepindolol.html

Mepindolol is a selective beta1-adrenoreceptor blocker with intrinsic sympathetic activity. Treatment with mepindolol dose not significantly affect the lipid levels - the total cholesterol in plasma was decreased by mepindolol but HDL-cholesterol increased. During beta-receptor blockade with mepindolol-sulfate angina was compensated, the unfavourable hemodynamic effects seen during placebo did not occur. No signs of congestive heart failure were found during mepindolol-sulfate-therapy. Mepindolol-sulfate showed a pronounced blood-pressure lowering effect.

Approval Year

PubMed

Title	Date	PubMed
Role of chemical structure in stereoselective recognition of beta-blockers and H1-antihistamines by human serum transferrin in capillary zone electrophoresis.	2006 Apr	16609932
Transdermal delivery of beta-blockers.	2006 May	16640500
Role of chemical structure in stereoselective recognition of beta-blockers by cyclodextrins in capillary zone electrophoresis.	2008 Apr 24	18022245

Sample Use Guides

In Vivo Use Guide

10 mg/day for three months

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:31:13 UTC 2023` Edited by `admin` on `Fri Dec 15 16:31:13 UTC 2023`
Record UNII	63523X4FBA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MEPINDOLOL SULFATE

Common Name

English

Mepindolol sulfate [WHO-DD]

Common Name

English

MEPINDOLOL SULFATE SALT [MI]

Common Name

English

2-PROPANOL, 1-((1-METHYLETHYL)AMINO)-3-((2-METHYL-1H-INDOL-4-YL)OXY)-, SULFATE (2:1)

Systematic Name

English

LF-17895

Code

English

LF 17-895

Code

English

LF-17-895

Code

English

CORINDOLAN

Brand Name

English

Code System Code Type Description

PUBCHEM

6917859