NORMETHADONE PICRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H25NO.C6H3N3O7
Molecular Weight	524.5225
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=C(C=C(C=C1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O.CCC(=O)C(CCN(C)C)(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=JRELAUZHQMUKRI-UHFFFAOYSA-N

InChI=1S/C20H25NO.C6H3N3O7/c1-4-19(22)20(15-16-21(2)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18;10-6-4(8(13)14)1-3(7(11)12)2-5(6)9(15)16/h5-14H,4,15-16H2,1-3H3;1-2,10H

HIDE SMILES / InChI

Molecular Formula	C20H25NO
Molecular Weight	295.4186
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C6H3N3O7
Molecular Weight	229.1039
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.rexall.ca/articles/view/1486/Cophylac

Normethadone is a derivate of opioid analgetic methadone, used as component of antitussive drops in Canada. Illicit drug.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Mu-type opioid receptor 61 Target ID: P33535\|\|\|Q64064 Gene ID: 25601.0 Gene Symbol: Oprm1 Target Organism: Rattus norvegicus (Rat) Sources: http://www.ncbi.nlm.nih.gov/pubmed/7602488	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cough 106 Sources: http://www.rexall.ca/articles/view/1486/Cophylac	Primary		Approved 8429	Cophylac Approved Use Cough

PubMed

Title	Date	PubMed
Phenyl-substituted normethadones: synthesis and pharmacology.	1995 Mar	7602488
Simultaneous screening and quantification of 25 opioid drugs in post-mortem blood and urine by liquid chromatography-tandem mass spectrometry.	2009 Apr 15	19232849

Sample Use Guides

In Vivo Use Guide

Cophylac (normethadone HCl 10 mg and p-hydroxyephedrine HCl 20 mg): 15 drops twice daily

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:16:00 GMT 2023` Edited by `admin` on `Sat Dec 16 11:16:00 GMT 2023`
Record UNII	632S02T2CC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NORMETHADONE PICRATE

Common Name

English

3-HEXANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, COMPD. WITH 2,4,6-TRINITROPHENOL (1:1)

Systematic Name

English

6-DIMETHYLAMINO-4,4-DIPHENYL-3-HEXANONE PICRATE

Systematic Name

English

NSC-400426

Code

English

3-HEXANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, PICRATE

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID60975280