TEOPRANITOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H22N6O7
Molecular Weight	410.3819
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12OC[C@H](O[N+]([O-])=O)[C@@]1([H])OC[C@@H]2NCCCN3C=NC4=C3C(=O)N(C)C(=O)N4C

InChI

InChIKey=XTEGRRHNMFDROI-YRRQLQLVSA-N

InChI=1S/C16H22N6O7/c1-19-14-11(15(23)20(2)16(19)24)21(8-18-14)5-3-4-17-9-6-27-13-10(29-22(25)26)7-28-12(9)13/h8-10,12-13,17H,3-7H2,1-2H3/t9-,10-,12+,13+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H22N6O7
Molecular Weight	410.3819
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3732290 | https://www.ncbi.nlm.nih.gov/pubmed/3137069 | https://adisinsight.springer.com/drugs/800000168

Teopranitol, a coronary vasodilator that was studied for the treatment of the acute myocardial ischemia. Animal experiments have shown that this compound stimulated the release of prostacyclin (PGI2)-like antiplatelet activity. However, the development of teopranitol was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Stereospecific stimulation of coronary vascular PGI2 by organic nitrates--studies with the new compound teopranitol (KC-046).	1984	6393969
[Changes in scintigraphically determined regional blood volume in coronary patients treated with the new substance teopranitol].	1984 Jun	6475177
Successful treatment of acute myocardial ischaemia with teopranitol--a novel organic nitrate.	1986 May	3732290
Stimulation of coronary vascular PGI2 by organic nitrates.	1988 Jan	3137069

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:31:29 GMT 2023` Edited by `admin` on `Sat Dec 16 16:31:29 GMT 2023`
Record UNII	631R1KON85
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TEOPRANITOL

Official Name

English

teopranitol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29707