BROXALDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H11Br2NO2
Molecular Weight	421.083
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=NC2=C(OC(=O)C3=CC=CC=C3)C(Br)=CC(Br)=C2C=C1

InChI

InChIKey=IJTPLVAAROHGGB-UHFFFAOYSA-N

InChI=1S/C17H11Br2NO2/c1-10-7-8-12-13(18)9-14(19)16(15(12)20-10)22-17(21)11-5-3-2-4-6-11/h2-9H,1H3

HIDE SMILES / InChI

Molecular Formula	C17H11Br2NO2
Molecular Weight	421.083
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/46561 | https://www.ncbi.nlm.nih.gov/pubmed/3081428 | https://www.ncbi.nlm.nih.gov/pubmed/4933138

Broxaldine, also known as brobenzoxaldine, is a dibromo derivative of quinaldine. It was used in combination with other halogenated hydroxyquinoline compound broxyquinoline (INTESTOPAN) for the treatment of intestinal amoebiasis and childhood diarrhea. In a specific ratio of 5/1, they were shown to act synergistically against several pathogens.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Intestinal amebiasis 4 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3081428	Curative		Not Provided 504	INTESTOPAN Approved Use Unknown
Childhood diarrhea 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4933138	Curative		Not Provided 504	INTESTOPAN Approved Use Unknown

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

A combination of broxyquinoline 500 mg and broxaldine 100 mg three times a day for one week.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:16:47 GMT 2023` Edited by `admin` on `Sat Dec 16 16:16:47 GMT 2023`
Record UNII	6308U1DL5F
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BROXALDINE

Official Name

English

broxaldine [INN]

Common Name

English

5,7-DIBROMO-2-METHYL-8-QUINOLINOL BENZOATE ESTER

Common Name

English

BROXALDINE [MART.]

Common Name

English

Broxaldine [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C277