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Details

Stereochemistry ACHIRAL
Molecular Formula C7H4O3.Bi.HO
Molecular Weight 362.0929
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BISMUTH SUBSALICYLATE

SMILES

c1ccc(c(c1)C(=O)[O-])[O-].[Bi+3].[OH-]

InChI

InChIKey=ZREIPSZUJIFJNP-UHFFFAOYSA-K
InChI=1S/C7H6O3.Bi.H2O/c8-6-4-2-1-3-5(6)7(9)10;;/h1-4,8H,(H,9,10);;1H2/q;+3;/p-3

HIDE SMILES / InChI

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C7H4O3
Molecular Weight 136.1051
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Bi
Molecular Weight 208.9804
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: https://www.drugs.com/international/bibrocathol.html | https://clinicaltrials.gov/ct2/show/NCT01357538 | https://www.drugs.com/international/noviform.html | https://www.ncbi.nlm.nih.gov/pubmed/17003947

Bibrocathol (trade names Noviform and Posiformin) is a well-established topical antiseptic for the treatment of acute eyelid diseases like blepharitis. Eye ointments containing 2 or 5 % bibrocathol and the excipients liquid paraffin, white soft paraffin, and lanolin have been marketed since 1967 for the treatment of eye irritation, chronic blepharitis, and uninfected corneal injuries. Reports of clinical experience with bibrocathol for inflammation of the edge of the palpebra exist since the beginning of the 20th century. Until recently, no controlled, randomized clinical studies according to the guidelines for Good Clinical Practice for Trials on Medical Products for Human Use (GCP) as defined by the International Conference on Harmonisation (ICH) have been performed with bibrocathol 2 % ointment, as these were not required for marketing authorization in the 1960s. A first double-blind, prospective, controlled, GCP-compliant clinical study was recently performed to assess the efficacy of bibrocathol 5 % (Noviform®) in acute blepharitis. It demonstrated superior efficacy of bibrocathol 5 % ointment as compared to an ointment vehicle (placebo) after 2 weeks of treatment as assessed by a combined measure of slit-lamp examination results and patients’ subjective complaints.

Originator

Sources: Medizinische Klinik (Muenchen, Germany) (1913), 8, 992.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Noviform

Sample Use Guides

A strip of 5 mm eye ointment applied 3 times per day to the eye lid
Route of Administration: Topical
Substance Class Chemical
Created
by admin
on Fri Jun 25 21:03:15 UTC 2021
Edited
by admin
on Fri Jun 25 21:03:15 UTC 2021
Record UNII
62TEY51RR1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BISMUTH SUBSALICYLATE
EP   GREEN BOOK   HSDB   JAN   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
USAN  
Official Name English
BISMUTH SALICYLATE [MART.]
Common Name English
(2-HYDROXYBENZOATO-O(SUP 1))-OXOBISMUTH
Common Name English
2-HYDROXYBENZOIC ACID BISMUTH (3+) SALT
Common Name English
BISMUTH SUBSALICYLATE [VANDF]
Common Name English
BISMUTH SUBSALICYLATE [JAN]
Common Name English
BISMUTH SUBSALICYLATE [HSDB]
Common Name English
BISMUTH SUBSALICYLATE [USAN]
Common Name English
BISMUTH SUBSALICYLATE [EP MONOGRAPH]
Common Name English
BISMUTH SUBSALICYLATE [GREEN BOOK]
Common Name English
4H-1,3,2-BENZODIOXABISMIN-4-ONE, 2-HYDROXY-
Systematic Name English
BISMUTH SUBSALICYLATE [USP-RS]
Common Name English
BISMUTH SUBSALICYLATE COMPONENT OF HELIDAC
Common Name English
NSC-759117
Code English
BISMUTH SUBSALICYLATE [ORANGE BOOK]
Common Name English
BISMUTH SUBSALICYLATE [MI]
Common Name English
BISMUTH SUBSALICYLATE [EP]
Common Name English
BISMUTH OXIDE SALICYLATE
Systematic Name English
HELIDAC COMPONENT BISMUTH SUBSALICYLATE
Common Name English
BISMUTH SUBSALICYLATE [WHO-DD]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 335.10
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
NCI_THESAURUS C266
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
NDF-RT N0000007888
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
NDF-RT N0000180183
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
NDF-RT N0000007888
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
CFR 21 CFR 335.50
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
NCI_THESAURUS C2080
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
Code System Code Type Description
FDA UNII
62TEY51RR1
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY
ChEMBL
CHEMBL1120
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY
DRUG BANK
DB01294
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY
ECHA (EC/EINECS)
238-953-1
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY
WIKIPEDIA
BISMUTH SUBSALICYLATE
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY
EVMPD
SUB13093MIG
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY
CAS
14882-18-9
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY
DRUG CENTRAL
4257
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY
HSDB
332
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY
RXCUI
19478
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY RxNorm
MERCK INDEX
M2555
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY Merck Index
PUBCHEM
53629521
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY
NCI_THESAURUS
C1020
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY
LACTMED
Bismuth Subsalicylate
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY
EPA CompTox
14882-18-9
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY
MESH
C015715
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY
USP_CATALOG
1075553
Created by admin on Fri Jun 25 21:03:15 UTC 2021 , Edited by admin on Fri Jun 25 21:03:15 UTC 2021
PRIMARY USP-RS
Related Record Type Details
PARENT -> SALT/SOLVATE
BINDER->LIGAND
BINDING
Related Record Type Details
ACTIVE MOIETY
ACTIVE MOIETY