ZIFROSILONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H13F3OSi
Molecular Weight	246.301
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[Si](C)(C)C1=CC(=CC=C1)C(=O)C(F)(F)F

InChI

InChIKey=GAPOASFZXBWUGS-UHFFFAOYSA-N

InChI=1S/C11H13F3OSi/c1-16(2,3)9-6-4-5-8(7-9)10(15)11(12,13)14/h4-7H,1-3H3

HIDE SMILES / InChI

Molecular Formula	C11H13F3OSi
Molecular Weight	246.301
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800001855 | https://www.ncbi.nlm.nih.gov/pubmed/7628183 | https://www.ncbi.nlm.nih.gov/pubmed/7821680

Zifrosilone (MDL 73745 or (2,2,2-trifluoro-1-(3-trimethylsilylphenyl)ethanone) is a acetylcholinesterase inhibitor. Zifrosilone was studied as a drug for the treatment of Alzheimer's disease however its development has been discontinued.

CNS Activity

Originator

Approval Year

Sample Use Guides

In Vivo Use Guide

Pharmacokinetics, pharmacodynamics, and tolerance of zifrosilone were studied in a double-blind, sequential, single-escalating-dose, randomized panel design. Each panel consisted of six subjects, with four subjects receiving zifrosilone (10, 30, 60, 90, 120, 150, 200, 250, and 300 mg orally) and two subjects receiving matching placebo.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:42:49 GMT 2025` Edited by `admin` on `Wed Apr 02 08:42:49 GMT 2025`
Record UNII	6275788O83
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MDL 73,745

Preferred Name

English

ZIFROSILONE

Official Name

English

MDL-73745

Code

English

ZIFROSILONE [USAN]

Common Name

English

2,2,2-Trifluoro-3’-(trimethylsilyl)acetophenone

Common Name

English

MDL73745

Code

English

ETHANONE, 2,2,2-TRIFLUORO-1-(3-(TRIMETHYLSILYL)PHENYL)-

Systematic Name

English

ZIFROSILONE [MART.]

Common Name

English

zifrosilone [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47792