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Details

Stereochemistry ACHIRAL
Molecular Formula C11H13F3OSi
Molecular Weight 246.301
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZIFROSILONE

SMILES

C[Si](C)(C)C1=CC=CC(=C1)C(=O)C(F)(F)F

InChI

InChIKey=GAPOASFZXBWUGS-UHFFFAOYSA-N
InChI=1S/C11H13F3OSi/c1-16(2,3)9-6-4-5-8(7-9)10(15)11(12,13)14/h4-7H,1-3H3

HIDE SMILES / InChI

Molecular Formula C11H13F3OSi
Molecular Weight 246.301
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Zifrosilone (MDL 73745 or (2,2,2-trifluoro-1-(3-trimethylsilylphenyl)ethanone) is a acetylcholinesterase inhibitor. Zifrosilone was studied as a drug for the treatment of Alzheimer's disease however its development has been discontinued.

CNS Activity

Curator's Comment: Zifrosilone is CNS active in animal model. No human data available.

Approval Year

Sample Use Guides

Pharmacokinetics, pharmacodynamics, and tolerance of zifrosilone were studied in a double-blind, sequential, single-escalating-dose, randomized panel design. Each panel consisted of six subjects, with four subjects receiving zifrosilone (10, 30, 60, 90, 120, 150, 200, 250, and 300 mg orally) and two subjects receiving matching placebo.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:03:33 UTC 2023
Edited
by admin
on Sat Dec 16 17:03:33 UTC 2023
Record UNII
6275788O83
Record Status Validated (UNII)
Record Version
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Name Type Language
ZIFROSILONE
INN   MART.   USAN  
INN   USAN  
Official Name English
MDL-73745
Code English
ZIFROSILONE [USAN]
Common Name English
MDL 73,745
Code English
2,2,2-Trifluoro-3’-(trimethylsilyl)acetophenone
Common Name English
MDL73745
Code English
ETHANONE, 2,2,2-TRIFLUORO-1-(3-(TRIMETHYLSILYL)PHENYL)-
Systematic Name English
ZIFROSILONE [MART.]
Common Name English
zifrosilone [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C47792
Created by admin on Sat Dec 16 17:03:34 UTC 2023 , Edited by admin on Sat Dec 16 17:03:34 UTC 2023
Code System Code Type Description
INN
7210
Created by admin on Sat Dec 16 17:03:34 UTC 2023 , Edited by admin on Sat Dec 16 17:03:34 UTC 2023
PRIMARY
MESH
C082826
Created by admin on Sat Dec 16 17:03:34 UTC 2023 , Edited by admin on Sat Dec 16 17:03:34 UTC 2023
PRIMARY
NCI_THESAURUS
C82222
Created by admin on Sat Dec 16 17:03:34 UTC 2023 , Edited by admin on Sat Dec 16 17:03:34 UTC 2023
PRIMARY
CAS
132236-18-1
Created by admin on Sat Dec 16 17:03:34 UTC 2023 , Edited by admin on Sat Dec 16 17:03:34 UTC 2023
PRIMARY
EVMPD
SUB00154MIG
Created by admin on Sat Dec 16 17:03:34 UTC 2023 , Edited by admin on Sat Dec 16 17:03:34 UTC 2023
PRIMARY
SMS_ID
100000079416
Created by admin on Sat Dec 16 17:03:34 UTC 2023 , Edited by admin on Sat Dec 16 17:03:34 UTC 2023
PRIMARY
FDA UNII
6275788O83
Created by admin on Sat Dec 16 17:03:34 UTC 2023 , Edited by admin on Sat Dec 16 17:03:34 UTC 2023
PRIMARY
USAN
EE-17
Created by admin on Sat Dec 16 17:03:34 UTC 2023 , Edited by admin on Sat Dec 16 17:03:34 UTC 2023
PRIMARY
EPA CompTox
DTXSID80157445
Created by admin on Sat Dec 16 17:03:34 UTC 2023 , Edited by admin on Sat Dec 16 17:03:34 UTC 2023
PRIMARY
PUBCHEM
60811
Created by admin on Sat Dec 16 17:03:34 UTC 2023 , Edited by admin on Sat Dec 16 17:03:34 UTC 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY