Details
Stereochemistry | ACHIRAL |
Molecular Formula | C11H13F3OSi |
Molecular Weight | 246.301 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C[Si](C)(C)C1=CC=CC(=C1)C(=O)C(F)(F)F
InChI
InChIKey=GAPOASFZXBWUGS-UHFFFAOYSA-N
InChI=1S/C11H13F3OSi/c1-16(2,3)9-6-4-5-8(7-9)10(15)11(12,13)14/h4-7H,1-3H3
Molecular Formula | C11H13F3OSi |
Molecular Weight | 246.301 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7781701
Curator's Comment: Zifrosilone is CNS active in animal model. No human data available.
Originator
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7628183
Pharmacokinetics, pharmacodynamics, and tolerance of zifrosilone were studied in a double-blind, sequential, single-escalating-dose, randomized panel design. Each panel consisted of six subjects, with four subjects receiving zifrosilone (10, 30, 60, 90, 120, 150, 200, 250, and 300 mg orally) and two subjects receiving matching placebo.
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 17:03:33 GMT 2023
by
admin
on
Sat Dec 16 17:03:33 GMT 2023
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Record UNII |
6275788O83
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C47792
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7210
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C082826
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C82222
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132236-18-1
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SUB00154MIG
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100000079416
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6275788O83
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EE-17
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DTXSID80157445
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60811
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ACTIVE MOIETY |
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