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Details

Stereochemistry ABSOLUTE
Molecular Formula C18H25N
Molecular Weight 255.3978
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIMEMORFAN

SMILES

[H][C@]12CCCC[C@]13CCN(C)[C@H]2CC4=CC=C(C)C=C34

InChI

InChIKey=KBEZZLAAKIIPFK-NJAFHUGGSA-N
InChI=1S/C18H25N/c1-13-6-7-14-12-17-15-5-3-4-8-18(15,16(14)11-13)9-10-19(17)2/h6-7,11,15,17H,3-5,8-10,12H2,1-2H3/t15-,17+,18+/m1/s1

HIDE SMILES / InChI
Molecular Formula C18H25N
Molecular Weight 255.3978
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Dimemorfan is a nonnarcotic antitussive drug. The antitussive action of dimemorfan appears to be directly on the cough center in the medulla.

CNS Activity

CNS Active
3913
Curator's Comment: Dimemorfan exhibits an anticonvulsant effect.

Originator

Yamanouchi Pharmaceutical
31
Curator's Comment: Yamanouchi Pharmaceutical now is a part of Astellas Pharma.

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
ASTOMIN

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan.
1999 Mar 13
Anti-amnesic effect of dimemorfan in mice.
2003 Mar
Dimemorfan enhances acetylcholine release from rat hippocampal slices.
2004 May 15
Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice.
2004 May 5
[Otorhinolaringologyc approach of the chronic cough. Clinical case].
2007
Patents

Patents

JP2001097856A
2
JP2001151677A
2
JP2005289904A
2
JP2005289905A
2
JP2005289906A
2
JPH1072349A
2

Sample Use Guides

In Vivo Use Guide
20 mg three times daily.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:05:56 UTC 2023
Edited
by admin
on Fri Dec 15 16:05:56 UTC 2023
Record UNII
623OAC38YU
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DIMEMORFAN
INN   MI   WHO-DD  
INN  
Official Name English
DIMEMORFAN [MI]
Common Name English
dimemorfan [INN]
Common Name English
Dimemorfan [WHO-DD]
Common Name English
(+)-3,17-DIMETHYLMORPHINAN
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C66917
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
WHO-VATC QR05DA11
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
WHO-ATC R05DA11
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
NCI_THESAURUS C264
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
Code System Code Type Description
MESH
C012621
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
PRIMARY
WIKIPEDIA
Dimemorfan
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
PRIMARY
ChEMBL
CHEMBL2106325
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
PRIMARY
MERCK INDEX
m4499
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
PRIMARY Merck Index
EVMPD
SUB07158MIG
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
PRIMARY
SMS_ID
100000082655
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
PRIMARY
DRUG BANK
DB13810
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
PRIMARY
CAS
36309-01-0
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
PRIMARY
FDA UNII
623OAC38YU
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
PRIMARY
PUBCHEM
3037918
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
PRIMARY
EPA CompTox
DTXSID301043335
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
PRIMARY
NCI_THESAURUS
C65399
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
PRIMARY
INN
3497
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
PRIMARY
DRUG CENTRAL
900
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
PRIMARY
ECHA (EC/EINECS)
252-963-3
Created by admin on Fri Dec 15 16:05:56 UTC 2023 , Edited by admin on Fri Dec 15 16:05:56 UTC 2023
PRIMARY
Related Record Type Details
Structure of DIMEMORFAN PHOSPHATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of DIMEMORFAN
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