AZD-5672

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C32H38F2N2O5S2
Molecular Weight	632.781
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(C1CCN(CC[C@H](C2=CC=C(C=C2)S(C)(=O)=O)C3=CC(F)=CC(F)=C3)CC1)C(=O)CC4=CC=C(C=C4)S(C)(=O)=O

InChI

InChIKey=SCXSQUUTGCWHFU-WJOKGBTCSA-N

InChI=1S/C32H38F2N2O5S2/c1-4-36(32(37)19-23-5-9-29(10-6-23)42(2,38)39)28-13-16-35(17-14-28)18-15-31(25-20-26(33)22-27(34)21-25)24-7-11-30(12-8-24)43(3,40)41/h5-12,20-22,28,31H,4,13-19H2,1-3H3/t31-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C32H38F2N2O5S2
Molecular Weight	632.781
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21075975 | https://clinicaltrials.gov/ct2/show/NCT00713544 | https://www.ncbi.nlm.nih.gov/pubmed/22266038

AZD5672 was developed by AstraZeneca for the treatment of rheumatoid arthritis. It was found that the drug inhibits P-glycoprotein and is a CCR5 antagonist. Exists hypothesis that inhibition of CCR5 can bring benefits in the treatment of rheumatoid arthritis. In July 2009, Phase-II for Rheumatoid arthritis was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis.	2012-02-15	22266038
Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis.	2006-03	16107514
Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis.	2001-05	11352233

Sample Use Guides

In Vivo Use Guide

20-150 mg once daily

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:57:23 GMT 2025` Edited by `admin` on `Mon Mar 31 19:57:23 GMT 2025`
Record UNII	61XQN688TW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AZD5672

Preferred Name

English

AZD-5672

Common Name

English

BENZENEACETAMIDE, N-(1-((3R)-3-(3,5-DIFLUOROPHENYL)-3-(4-(METHYLSULFONYL)PHENYL)PROPYL)-4-PIPERIDINYL)-N-ETHYL-4-(METHYLSULFONYL)-

Systematic Name

English

Code System Code Type Description

CAS

780750-65-4