ADENOSINE DIPHOSPHATE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H15N5O10P2
Molecular Weight	427.2011
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O

InChI

InChIKey=XTWYTFMLZFPYCI-KQYNXXCUSA-N

InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C10H15N5O10P2
Molecular Weight	427.2011
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Potency
Purinergic receptor P2Y1 2 Target ID: CHEMBL4315 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26447940	Agonist 2678	24.0 nM [EC50]
Pyrimidinergic receptor P2Y6 6 Target ID: CHEMBL4714 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8670200	Agonist 2678	30.0 µM [EC50]
P2Y purinoceptor 13 2 Target ID: CHEMBL3321651 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12815166	Agonist 2678	308.0 nM [IC50]
Transient receptor potential cation channel subfamily M member 4 2 Target ID: CHEMBL1628469 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14758478	Inhibitor 8297	2.2 µM [IC50]

PubMed

Title	Date	PubMed
C-reactive protein in the hemolymph of Achatina fulica: interrelationship with sex steroids and metallothionein.	2000 Apr	10840224
Of mice and men: K(ATP) channels and insulin secretion.	2001	11237225
Effect of gamma radiation on the in vitro aggregability of WBC-reduced apheresis platelets.	2001 Feb	11239229
Rapid assessment of glycoprotein IIb/IIIa blockade with the platelet function analyzer (PFA-100) during percutaneous coronary intervention.	2001 Feb	11174336
Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor.	2001 Feb	11168423
NAD+ inhibits the self-splicing of the group I intron.	2001 Feb 16	11178981
Regulation of ATPase and chaperone cycle of DnaK from Thermus thermophilus by the nucleotide exchange factor GrpE.	2001 Feb 2	11162122
Increase in nuclear calcium in smooth muscle cells exposed to oxidized low density lipoprotein.	2001 Jan	11234999
Neonatal platelet activation in preeclampsia.	2001 Jan	11190901
Energy stores and metabolites in chronic reversibly and irreversibly dysfunctional myocardium in humans.	2001 Jan	11153723
Guanabenz, an antihypertensive centrally acting alpha2-agonist, suppresses morning elevations in aggregation of human platelets.	2001 Jan	11152378
c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia.	2001 Jan 1	11133753
Cardiovascular biology. Small cells, big issues.	2001 Jan 11	11196625
Excluded volume effects on the refolding and assembly of an oligomeric protein. GroEL, a case study.	2001 Jan 12	11020386
Phosphate exchange and ATP synthesis by DMSO-pretreated purified bovine mitochondrial ATP synthase.	2001 Jan 15	11139383
Altered mitochondrial sensitivity for ADP and maintenance of creatine-stimulated respiration in oxidative striated muscles from VDAC1-deficient mice.	2001 Jan 19	11044447
X-ray diffraction evidence for the lack of stereospecific protein interactions in highly activated actomyosin complex.	2001 Jan 26	11162098
Nucleotide-dependent single- to double-headed binding of kinesin.	2001 Jan 26	11158681
[Identification and isolation of GTP-binding regulator protein from plasma membranes of oocytes from the starfish Asterias amurensis].	2001 Jan-Feb	11236575
Significance of endothelial prostacyclin and nitric oxide in peripheral and pulmonary circulation.	2001 Jan-Feb	11208485
Molecular dynamics study of the energetic, mechanistic, and structural implications of a closed phosphate tube in ncd.	2001 Mar	11222280
Cross-talk between catalytic and regulatory elements in a DEAD motor domain is essential for SecA function.	2001 Mar 1	11230120
Evidence for the selective population of FeMo cofactor sites in MoFe protein and its molecular recognition by the Fe protein in transition state complex analogues of nitrogenase.	2001 Mar 2	11084023
Molecular mechanism for functional interaction between DnaA protein and acidic phospholipids: identification of important amino acids.	2001 Mar 9	11102450
Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors.	2001 May 4	11154698

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:20:09 GMT 2023` Edited by `admin` on `Fri Dec 15 15:20:09 GMT 2023`
Record UNII	61D2G4IYVH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ADENOSINE DIPHOSPHATE

Systematic Name

English

Adenosine diphosphate [WHO-DD]

Common Name

English

ADENOSINE 5'-(TRIHYDROGEN DIPHOSPHATE)

Systematic Name

English

ADP

Common Name

English

ADENOSINE, 5'-(TRIHYDROGEN PYROPHOSPHATE)

Common Name

English

ADENOSINE DIPHOSPHATE [MI]

Common Name

English

Classification Tree Code System Code

LOINC

1724-4