ADENOSINE DIPHOSPHATE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H15N5O10P2
Molecular Weight	427.2011
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O

InChI

InChIKey=XTWYTFMLZFPYCI-KQYNXXCUSA-N

InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C10H15N5O10P2
Molecular Weight	427.2011
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Potency
Purinergic receptor P2Y1 2 Target ID: CHEMBL4315 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26447940	Agonist 2678	24.0 nM [EC50]
Pyrimidinergic receptor P2Y6 6 Target ID: CHEMBL4714 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8670200	Agonist 2678	30.0 µM [EC50]
P2Y purinoceptor 13 2 Target ID: CHEMBL3321651 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12815166	Agonist 2678	308.0 nM [IC50]
Transient receptor potential cation channel subfamily M member 4 2 Target ID: CHEMBL1628469 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14758478	Inhibitor 8297	2.2 µM [IC50]

PubMed

Title	Date	PubMed
Adenine-induced selective apoptosis toward HIV chronically infected cells in vitro.	2000 Jul 14	10891366
Co-transmitter function of ATP in central catecholaminergic neurons of the rat.	2001	11226696
Properties of native P2X receptors in rat trigeminal mesencephalic nucleus neurones: lack of correlation with known, heterologously expressed P2X receptors.	2001	11077075
Role of ETB and B2 receptors in the ex vivo platelet inhibitory properties of endothelin and bradykinin in the mouse.	2001 Feb	11181435
Free ATP inhibits thimet oligopeptidase (EC 3.4.24.15) activity, induces autophosphorylation in vitro, and controls oligopeptide degradation in macrophage.	2001 Feb	11179954
Diazoxide protects mitochondria from anoxic injury: implications for myopreservation.	2001 Feb	11174735
Rapid assessment of glycoprotein IIb/IIIa blockade with the platelet function analyzer (PFA-100) during percutaneous coronary intervention.	2001 Feb	11174336
Maintenance of GABA receptor function of small-diameter cockroach neurons by adenine nucleotides.	2001 Feb	11164343
Adenosine diphosphate strongly potentiates the ability of the chemokines MDC, TARC, and SDF-1 to stimulate platelet function.	2001 Feb 15	11159520
NAD+ inhibits the self-splicing of the group I intron.	2001 Feb 16	11178981
ADP-insensitive phosphoenzyme intermediate of sarcoplasmic reticulum Ca(2+)-ATPase has a compact conformation resistant to proteinase K, V8 protease and trypsin.	2001 Feb 2	11165264
A 1.8 A resolution structure of pig muscle 3-phosphoglycerate kinase with bound MgADP and 3-phosphoglycerate in open conformation: new insight into the role of the nucleotide in domain closure.	2001 Feb 23	11178909
Force dependence of the Michaelis constant in a two-state ratchet model for molecular motors.	2001 Feb 5	11178028
Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist.	2001 Feb 6	11156884
The effect of a novel glycoprotein IIb/IIIa antagonist, SR 121566A, on platelet aggregation and activation in rhesus monkeys.	2001 Jan	11190897
P2 receptor agonists stimulate insulin release from human pancreatic islets.	2001 Jan	11138974
Active-control trials: how would a new agent compare with placebo? A method illustrated with clopidogrel, aspirin, and placebo.	2001 Jan	11136483
Matrix metalloproteinase 2 in tumor cell-induced platelet aggregation: regulation by nitric oxide.	2001 Jan 1	11196190
Identification of the platelet ADP receptor targeted by antithrombotic drugs.	2001 Jan 11	11196645
Cardiovascular biology. Small cells, big issues.	2001 Jan 11	11196625
Analysis of gain-of-function mutants of an ATP-dependent regulator of Tn7 transposition.	2001 Jan 19	11152618
Altered mitochondrial sensitivity for ADP and maintenance of creatine-stimulated respiration in oxidative striated muscles from VDAC1-deficient mice.	2001 Jan 19	11044447
[Identification and isolation of GTP-binding regulator protein from plasma membranes of oocytes from the starfish Asterias amurensis].	2001 Jan-Feb	11236575
Effect of ions and nucleotides on the interactions of yeast Rad51 protein with single-stranded oligonucleotides.	2001 Mar	11226888
Purification and characterization of homo- and hetero-dimeric acetate kinases from the sulfate-reducing bacterium Desulfovibrio vulgaris.	2001 Mar	11226881
Effects of KRN2391 on ionic currents in rabbit femoral arterial myocytes.	2001 Mar	11226147
GrpE accelerates peptide binding and release from the high affinity state of DnaK.	2001 Mar	11224572
Successful nonfreezing, subzero preservation of rat liver with 2,3-butanediol and type I antifreeze protein.	2001 Mar	11180993
Temporal effect of alcohol consumption on reactivity of pial arterioles: role of oxygen radicals.	2001 Mar	11179040
Theoretical studies on the regulation of oxidative phosphorylation in intact tissues.	2001 Mar 1	11239483
ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999.	2001 Mar 16	11104774
Exogenous Mg-ATP induces a large inhibition of pyruvate kinase in intact rat hepatocytes.	2001 Mar 2	11104754
Interleukin-3 withdrawal induces an early increase in mitochondrial membrane potential unrelated to the Bcl-2 family. Roles of intracellular pH, ADP transport, and F(0)F(1)-ATPase.	2001 Mar 2	11102440
Mitochondrial Hsp70 Ssc1: role in protein folding.	2001 Mar 2	11096111
Changes in cortical and hippocampal ectonucleotidase activities in mice lacking cellular prion protein.	2001 Mar 23	11239719
Adhesion of adenosine diphosphate-activated platelets to human brain microvascular endothelial cells under flow in vitro is mediated via GPIIb/IIIa.	2001 Mar 23	11239710
Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates.	2001 Mar 23	11121420
Rotavirus nonstructural protein NSP2 self-assembles into octamers that undergo ligand-induced conformational changes.	2001 Mar 30	11121414
Molecular mechanism for functional interaction between DnaA protein and acidic phospholipids: identification of important amino acids.	2001 Mar 9	11102450
Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding.	2001 Mar 9	11099504
Mouse ribonucleotide reductase control: influence of substrate binding upon interactions with allosteric effectors.	2001 Mar 9	11099495

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:20:09 GMT 2023` Edited by `admin` on `Fri Dec 15 15:20:09 GMT 2023`
Record UNII	61D2G4IYVH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ADENOSINE DIPHOSPHATE

Systematic Name

English

Adenosine diphosphate [WHO-DD]

Common Name

English

ADENOSINE 5'-(TRIHYDROGEN DIPHOSPHATE)

Systematic Name

English

ADP

Common Name

English

ADENOSINE, 5'-(TRIHYDROGEN PYROPHOSPHATE)

Common Name

English

ADENOSINE DIPHOSPHATE [MI]

Common Name

English

Classification Tree Code System Code

LOINC

1724-4