Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C10H15N5O10P2 |
Molecular Weight | 427.2011 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O
InChI
InChIKey=XTWYTFMLZFPYCI-KQYNXXCUSA-N
InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
Molecular Formula | C10H15N5O10P2 |
Molecular Weight | 427.2011 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL4315 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26447940 |
24.0 nM [EC50] | ||
Target ID: CHEMBL4714 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8670200 |
30.0 µM [EC50] | ||
Target ID: CHEMBL3321651 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12815166 |
308.0 nM [IC50] | ||
Target ID: CHEMBL1628469 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14758478 |
2.2 µM [IC50] |
PubMed
Title | Date | PubMed |
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Adenine-induced selective apoptosis toward HIV chronically infected cells in vitro. | 2000 Jul 14 |
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Co-transmitter function of ATP in central catecholaminergic neurons of the rat. | 2001 |
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Properties of native P2X receptors in rat trigeminal mesencephalic nucleus neurones: lack of correlation with known, heterologously expressed P2X receptors. | 2001 |
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Role of ETB and B2 receptors in the ex vivo platelet inhibitory properties of endothelin and bradykinin in the mouse. | 2001 Feb |
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Free ATP inhibits thimet oligopeptidase (EC 3.4.24.15) activity, induces autophosphorylation in vitro, and controls oligopeptide degradation in macrophage. | 2001 Feb |
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Diazoxide protects mitochondria from anoxic injury: implications for myopreservation. | 2001 Feb |
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Rapid assessment of glycoprotein IIb/IIIa blockade with the platelet function analyzer (PFA-100) during percutaneous coronary intervention. | 2001 Feb |
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Maintenance of GABA receptor function of small-diameter cockroach neurons by adenine nucleotides. | 2001 Feb |
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Adenosine diphosphate strongly potentiates the ability of the chemokines MDC, TARC, and SDF-1 to stimulate platelet function. | 2001 Feb 15 |
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NAD+ inhibits the self-splicing of the group I intron. | 2001 Feb 16 |
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ADP-insensitive phosphoenzyme intermediate of sarcoplasmic reticulum Ca(2+)-ATPase has a compact conformation resistant to proteinase K, V8 protease and trypsin. | 2001 Feb 2 |
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A 1.8 A resolution structure of pig muscle 3-phosphoglycerate kinase with bound MgADP and 3-phosphoglycerate in open conformation: new insight into the role of the nucleotide in domain closure. | 2001 Feb 23 |
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Force dependence of the Michaelis constant in a two-state ratchet model for molecular motors. | 2001 Feb 5 |
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Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist. | 2001 Feb 6 |
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The effect of a novel glycoprotein IIb/IIIa antagonist, SR 121566A, on platelet aggregation and activation in rhesus monkeys. | 2001 Jan |
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P2 receptor agonists stimulate insulin release from human pancreatic islets. | 2001 Jan |
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Active-control trials: how would a new agent compare with placebo? A method illustrated with clopidogrel, aspirin, and placebo. | 2001 Jan |
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Matrix metalloproteinase 2 in tumor cell-induced platelet aggregation: regulation by nitric oxide. | 2001 Jan 1 |
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Identification of the platelet ADP receptor targeted by antithrombotic drugs. | 2001 Jan 11 |
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Cardiovascular biology. Small cells, big issues. | 2001 Jan 11 |
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Analysis of gain-of-function mutants of an ATP-dependent regulator of Tn7 transposition. | 2001 Jan 19 |
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Altered mitochondrial sensitivity for ADP and maintenance of creatine-stimulated respiration in oxidative striated muscles from VDAC1-deficient mice. | 2001 Jan 19 |
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[Identification and isolation of GTP-binding regulator protein from plasma membranes of oocytes from the starfish Asterias amurensis]. | 2001 Jan-Feb |
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Effect of ions and nucleotides on the interactions of yeast Rad51 protein with single-stranded oligonucleotides. | 2001 Mar |
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Purification and characterization of homo- and hetero-dimeric acetate kinases from the sulfate-reducing bacterium Desulfovibrio vulgaris. | 2001 Mar |
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Effects of KRN2391 on ionic currents in rabbit femoral arterial myocytes. | 2001 Mar |
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GrpE accelerates peptide binding and release from the high affinity state of DnaK. | 2001 Mar |
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Successful nonfreezing, subzero preservation of rat liver with 2,3-butanediol and type I antifreeze protein. | 2001 Mar |
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Temporal effect of alcohol consumption on reactivity of pial arterioles: role of oxygen radicals. | 2001 Mar |
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Theoretical studies on the regulation of oxidative phosphorylation in intact tissues. | 2001 Mar 1 |
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ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999. | 2001 Mar 16 |
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Exogenous Mg-ATP induces a large inhibition of pyruvate kinase in intact rat hepatocytes. | 2001 Mar 2 |
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Interleukin-3 withdrawal induces an early increase in mitochondrial membrane potential unrelated to the Bcl-2 family. Roles of intracellular pH, ADP transport, and F(0)F(1)-ATPase. | 2001 Mar 2 |
|
Mitochondrial Hsp70 Ssc1: role in protein folding. | 2001 Mar 2 |
|
Changes in cortical and hippocampal ectonucleotidase activities in mice lacking cellular prion protein. | 2001 Mar 23 |
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Adhesion of adenosine diphosphate-activated platelets to human brain microvascular endothelial cells under flow in vitro is mediated via GPIIb/IIIa. | 2001 Mar 23 |
|
Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates. | 2001 Mar 23 |
|
Rotavirus nonstructural protein NSP2 self-assembles into octamers that undergo ligand-induced conformational changes. | 2001 Mar 30 |
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Molecular mechanism for functional interaction between DnaA protein and acidic phospholipids: identification of important amino acids. | 2001 Mar 9 |
|
Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding. | 2001 Mar 9 |
|
Mouse ribonucleotide reductase control: influence of substrate binding upon interactions with allosteric effectors. | 2001 Mar 9 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:20:09 GMT 2023
by
admin
on
Fri Dec 15 15:20:09 GMT 2023
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Record UNII |
61D2G4IYVH
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Record Status |
Validated (UNII)
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Record Version |
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LOINC |
1724-4
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LOINC |
73675-1
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LOINC |
35135-3
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LOINC |
82871-5
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Code System | Code | Type | Description | ||
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100000077979
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200-392-5
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ADENOSINE DIPHOSPHATE
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6022
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61D2G4IYVH
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58-64-0
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SUB12740MIG
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DTXSID60883210
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m1412
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PRIMARY | Merck Index | ||
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16761
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D000244
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Related Record | Type | Details | ||
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METABOLIC ENZYME -> SUBSTRATE |
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TARGET -> AGONIST |
Leads to platelet activation
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