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Details

Stereochemistry ABSOLUTE
Molecular Formula C10H15N5O10P2
Molecular Weight 427.2011
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ADENOSINE DIPHOSPHATE

SMILES

NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O

InChI

InChIKey=XTWYTFMLZFPYCI-KQYNXXCUSA-N
InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

HIDE SMILES / InChI

Molecular Formula C10H15N5O10P2
Molecular Weight 427.2011
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
24.0 nM [EC50]
30.0 µM [EC50]
308.0 nM [IC50]
2.2 µM [IC50]
PubMed

PubMed

TitleDatePubMed
Adenine-induced selective apoptosis toward HIV chronically infected cells in vitro.
2000 Jul 14
Co-transmitter function of ATP in central catecholaminergic neurons of the rat.
2001
Properties of native P2X receptors in rat trigeminal mesencephalic nucleus neurones: lack of correlation with known, heterologously expressed P2X receptors.
2001
Role of ETB and B2 receptors in the ex vivo platelet inhibitory properties of endothelin and bradykinin in the mouse.
2001 Feb
Free ATP inhibits thimet oligopeptidase (EC 3.4.24.15) activity, induces autophosphorylation in vitro, and controls oligopeptide degradation in macrophage.
2001 Feb
Diazoxide protects mitochondria from anoxic injury: implications for myopreservation.
2001 Feb
Rapid assessment of glycoprotein IIb/IIIa blockade with the platelet function analyzer (PFA-100) during percutaneous coronary intervention.
2001 Feb
Maintenance of GABA receptor function of small-diameter cockroach neurons by adenine nucleotides.
2001 Feb
Adenosine diphosphate strongly potentiates the ability of the chemokines MDC, TARC, and SDF-1 to stimulate platelet function.
2001 Feb 15
NAD+ inhibits the self-splicing of the group I intron.
2001 Feb 16
ADP-insensitive phosphoenzyme intermediate of sarcoplasmic reticulum Ca(2+)-ATPase has a compact conformation resistant to proteinase K, V8 protease and trypsin.
2001 Feb 2
A 1.8 A resolution structure of pig muscle 3-phosphoglycerate kinase with bound MgADP and 3-phosphoglycerate in open conformation: new insight into the role of the nucleotide in domain closure.
2001 Feb 23
Force dependence of the Michaelis constant in a two-state ratchet model for molecular motors.
2001 Feb 5
Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist.
2001 Feb 6
The effect of a novel glycoprotein IIb/IIIa antagonist, SR 121566A, on platelet aggregation and activation in rhesus monkeys.
2001 Jan
P2 receptor agonists stimulate insulin release from human pancreatic islets.
2001 Jan
Active-control trials: how would a new agent compare with placebo? A method illustrated with clopidogrel, aspirin, and placebo.
2001 Jan
Matrix metalloproteinase 2 in tumor cell-induced platelet aggregation: regulation by nitric oxide.
2001 Jan 1
Identification of the platelet ADP receptor targeted by antithrombotic drugs.
2001 Jan 11
Cardiovascular biology. Small cells, big issues.
2001 Jan 11
Analysis of gain-of-function mutants of an ATP-dependent regulator of Tn7 transposition.
2001 Jan 19
Altered mitochondrial sensitivity for ADP and maintenance of creatine-stimulated respiration in oxidative striated muscles from VDAC1-deficient mice.
2001 Jan 19
[Identification and isolation of GTP-binding regulator protein from plasma membranes of oocytes from the starfish Asterias amurensis].
2001 Jan-Feb
Effect of ions and nucleotides on the interactions of yeast Rad51 protein with single-stranded oligonucleotides.
2001 Mar
Purification and characterization of homo- and hetero-dimeric acetate kinases from the sulfate-reducing bacterium Desulfovibrio vulgaris.
2001 Mar
Effects of KRN2391 on ionic currents in rabbit femoral arterial myocytes.
2001 Mar
GrpE accelerates peptide binding and release from the high affinity state of DnaK.
2001 Mar
Successful nonfreezing, subzero preservation of rat liver with 2,3-butanediol and type I antifreeze protein.
2001 Mar
Temporal effect of alcohol consumption on reactivity of pial arterioles: role of oxygen radicals.
2001 Mar
Theoretical studies on the regulation of oxidative phosphorylation in intact tissues.
2001 Mar 1
ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999.
2001 Mar 16
Exogenous Mg-ATP induces a large inhibition of pyruvate kinase in intact rat hepatocytes.
2001 Mar 2
Interleukin-3 withdrawal induces an early increase in mitochondrial membrane potential unrelated to the Bcl-2 family. Roles of intracellular pH, ADP transport, and F(0)F(1)-ATPase.
2001 Mar 2
Mitochondrial Hsp70 Ssc1: role in protein folding.
2001 Mar 2
Changes in cortical and hippocampal ectonucleotidase activities in mice lacking cellular prion protein.
2001 Mar 23
Adhesion of adenosine diphosphate-activated platelets to human brain microvascular endothelial cells under flow in vitro is mediated via GPIIb/IIIa.
2001 Mar 23
Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates.
2001 Mar 23
Rotavirus nonstructural protein NSP2 self-assembles into octamers that undergo ligand-induced conformational changes.
2001 Mar 30
Molecular mechanism for functional interaction between DnaA protein and acidic phospholipids: identification of important amino acids.
2001 Mar 9
Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding.
2001 Mar 9
Mouse ribonucleotide reductase control: influence of substrate binding upon interactions with allosteric effectors.
2001 Mar 9
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:20:09 GMT 2023
Edited
by admin
on Fri Dec 15 15:20:09 GMT 2023
Record UNII
61D2G4IYVH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ADENOSINE DIPHOSPHATE
MI   WHO-DD  
Systematic Name English
Adenosine diphosphate [WHO-DD]
Common Name English
ADENOSINE 5'-(TRIHYDROGEN DIPHOSPHATE)
Systematic Name English
ADP
Common Name English
ADENOSINE, 5'-(TRIHYDROGEN PYROPHOSPHATE)
Common Name English
ADENOSINE DIPHOSPHATE [MI]
Common Name English
Classification Tree Code System Code
LOINC 1724-4
Created by admin on Fri Dec 15 15:20:09 GMT 2023 , Edited by admin on Fri Dec 15 15:20:09 GMT 2023
LOINC 73675-1
Created by admin on Fri Dec 15 15:20:09 GMT 2023 , Edited by admin on Fri Dec 15 15:20:09 GMT 2023
LOINC 35135-3
Created by admin on Fri Dec 15 15:20:09 GMT 2023 , Edited by admin on Fri Dec 15 15:20:09 GMT 2023
LOINC 82871-5
Created by admin on Fri Dec 15 15:20:09 GMT 2023 , Edited by admin on Fri Dec 15 15:20:09 GMT 2023
Code System Code Type Description
SMS_ID
100000077979
Created by admin on Fri Dec 15 15:20:09 GMT 2023 , Edited by admin on Fri Dec 15 15:20:09 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-392-5
Created by admin on Fri Dec 15 15:20:09 GMT 2023 , Edited by admin on Fri Dec 15 15:20:09 GMT 2023
PRIMARY
WIKIPEDIA
ADENOSINE DIPHOSPHATE
Created by admin on Fri Dec 15 15:20:09 GMT 2023 , Edited by admin on Fri Dec 15 15:20:09 GMT 2023
PRIMARY
PUBCHEM
6022
Created by admin on Fri Dec 15 15:20:09 GMT 2023 , Edited by admin on Fri Dec 15 15:20:09 GMT 2023
PRIMARY
FDA UNII
61D2G4IYVH
Created by admin on Fri Dec 15 15:20:09 GMT 2023 , Edited by admin on Fri Dec 15 15:20:09 GMT 2023
PRIMARY
CAS
58-64-0
Created by admin on Fri Dec 15 15:20:09 GMT 2023 , Edited by admin on Fri Dec 15 15:20:09 GMT 2023
PRIMARY
EVMPD
SUB12740MIG
Created by admin on Fri Dec 15 15:20:09 GMT 2023 , Edited by admin on Fri Dec 15 15:20:09 GMT 2023
PRIMARY
EPA CompTox
DTXSID60883210
Created by admin on Fri Dec 15 15:20:09 GMT 2023 , Edited by admin on Fri Dec 15 15:20:09 GMT 2023
PRIMARY
MERCK INDEX
m1412
Created by admin on Fri Dec 15 15:20:09 GMT 2023 , Edited by admin on Fri Dec 15 15:20:09 GMT 2023
PRIMARY Merck Index
CHEBI
16761
Created by admin on Fri Dec 15 15:20:09 GMT 2023 , Edited by admin on Fri Dec 15 15:20:09 GMT 2023
PRIMARY
MESH
D000244
Created by admin on Fri Dec 15 15:20:09 GMT 2023 , Edited by admin on Fri Dec 15 15:20:09 GMT 2023
PRIMARY
Related Record Type Details
METABOLIC ENZYME -> SUBSTRATE
TARGET -> AGONIST
Leads to platelet activation