OLRADIPINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H28Cl2N2O6
Molecular Weight	487.374
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1=C(COCCOCCN)NC(C)=C(C1C2=CC=CC(Cl)=C2Cl)C(=O)OC

InChI

InChIKey=VLTBMBOHGZAWIT-UHFFFAOYSA-N

InChI=1S/C22H28Cl2N2O6/c1-4-32-22(28)19-16(12-31-11-10-30-9-8-25)26-13(2)17(21(27)29-3)18(19)14-6-5-7-15(23)20(14)24/h5-7,18,26H,4,8-12,25H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C22H28Cl2N2O6
Molecular Weight	487.374
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1709243 | https://adisinsight.springer.com/drugs/800000221

Olradipine (also known as S 11568) is a L-type Ca(2+) channel antagonist. This drug was being developed in France for the treatment of heart failure, hypertension, and ischemic heart disorder. However, all these studies were discontinued.

Approval Year

PubMed

Title	Date	PubMed
Ca2+ channel inhibition by a new dihydropyridine derivative, S11568, and its enantiomers S12967 and S12968.	1990 Nov 6	1706275
Inhibition of L-type but not T-type calcium channel current by a new dihydropyridine derivative, S11568.	1991 Feb	1709243
Ca2+ channel inhibition in a rat osteoblast-like cell line, UMR 106, by a new dihydropyridine derivative, S11568.	1992 Sep 10	1385178
Myocardial kinetics of the (11)C-labeled enantiomers of the Ca(2+) channel inhibitor S11568: an in vivo study.	2001 Jun	11390559

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:29:36 GMT 2023` Edited by `admin` on `Fri Dec 15 16:29:36 GMT 2023`
Record UNII	617O238A6V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OLRADIPINE

Official Name

English

olradipine [INN]

Common Name

English

3-ETHYL 5-METHYL (±)-2-((2-(2-AMINOETHOXY)ETHOXY)METHYL)-4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5-PYRIDINEDICARBOXYLATE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C333