Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C21H25N3O2S2 |
| Molecular Weight | 415.572 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)S(=O)(=O)C1=CC=C2SC3=C(C=CC=C3)N(C4CN5CCC4CC5)C2=C1
InChI
InChIKey=HTHHBTMNLHMBHQ-UHFFFAOYSA-N
InChI=1S/C21H25N3O2S2/c1-22(2)28(25,26)16-7-8-21-18(13-16)24(17-5-3-4-6-20(17)27-21)19-14-23-11-9-15(19)10-12-23/h3-8,13,15,19H,9-12,14H2,1-2H3
| Molecular Formula | C21H25N3O2S2 |
| Molecular Weight | 415.572 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Quisultazine is a phenothiazine derivative patented by MARPHA Societe d'Etude et d'Exploitation de Marques as pentagastrin antagonist. In preclinical studies, Quisultazine weakly inhibited pentagastrin-stimulated gastric secretion but was a powerful inhibitor of nocturnal gastric secretion. Quisultazine possesses a very weak affinity to muscarinic receptors in vitro and in vivo. It has negligible anticholinergic properties in rats and mice at the peripheral level but no effect at the central level.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Inhibition of pentagastrin-stimulated and overnight gastric secretion by LM24056, a new phenothiazine-derived antisecretory drug. | 1981 Feb 28 |
|
| The gastric antisecretory activity of a phenothiazine molecule, LM 24056. | 1982 |
|
| N,N-dimethyl-10-(3-quinuclidinyl)-2-phenothiazine sulfonamide (LM 24056): mode of action of its gastric antisecretory effect. | 1983 |
Patents
| Substance Class |
Chemical
Created
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admin
on
Edited
Fri Dec 15 16:05:44 GMT 2023
by
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| Record UNII |
60J29WG4Q6
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| Record Status |
Validated (UNII)
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| Record Version |
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29702
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SUB10228MIG
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100000080284
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60J29WG4Q6
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5133
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C81157
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64099-44-1
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DTXSID40867053
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68833
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CHEMBL2105307
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264-671-3
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
