QUISULTAZINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H25N3O2S2
Molecular Weight	415.572
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)S(=O)(=O)C1=CC=C2SC3=C(C=CC=C3)N(C4CN5CCC4CC5)C2=C1

InChI

InChIKey=HTHHBTMNLHMBHQ-UHFFFAOYSA-N

InChI=1S/C21H25N3O2S2/c1-22(2)28(25,26)16-7-8-21-18(13-16)24(17-5-3-4-6-20(17)27-21)19-14-23-11-9-15(19)10-12-23/h3-8,13,15,19H,9-12,14H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C21H25N3O2S2
Molecular Weight	415.572
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6110093 | https://www.ncbi.nlm.nih.gov/pubmed/6140926 | https://www.ncbi.nlm.nih.gov/pubmed/7144436

Quisultazine is a phenothiazine derivative patented by MARPHA Societe d'Etude et d'Exploitation de Marques as pentagastrin antagonist. In preclinical studies, Quisultazine weakly inhibited pentagastrin-stimulated gastric secretion but was a powerful inhibitor of nocturnal gastric secretion. Quisultazine possesses a very weak affinity to muscarinic receptors in vitro and in vivo. It has negligible anticholinergic properties in rats and mice at the peripheral level but no effect at the central level.

Originator

Approval Year

PubMed

Title	Date	PubMed
N,N-dimethyl-10-(3-quinuclidinyl)-2-phenothiazine sulfonamide (LM 24056): mode of action of its gastric antisecretory effect.	1983	6140926
The gastric antisecretory activity of a phenothiazine molecule, LM 24056.	1982	6814453
Inhibition of pentagastrin-stimulated and overnight gastric secretion by LM24056, a new phenothiazine-derived antisecretory drug.	1981-02-28	6110093

Patents

Sample Use Guides

In Vivo Use Guide

100,200, and 300 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:18:47 GMT 2025` Edited by `admin` on `Mon Mar 31 18:18:47 GMT 2025`
Record UNII	60J29WG4Q6
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

10H-PHENOTHIAZINE-2-SULFONAMIDE, 10-(1-AZABICYCLO(2.2.2)OCT-3-YL)-N,N-DIMETHYL-

Preferred Name

English

QUISULTAZINE

Official Name

English

quisultazine [INN]

Common Name

English

N,N-DIMETHYL-10-(3-QUINUCLIDINYL)PHENOTHIAZINE-2-SULFONAMIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29702