FEBARBAMATE

Details

Stereochemistry	MIXED
Molecular Formula	C20H27N3O6
Molecular Weight	405.4449
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCOCC(CN1C(=O)NC(=O)C(CC)(C1=O)C2=CC=CC=C2)OC(N)=O

InChI

InChIKey=QHZQILHUJDRDAI-UHFFFAOYSA-N

InChI=1S/C20H27N3O6/c1-3-5-11-28-13-15(29-18(21)26)12-23-17(25)20(4-2,16(24)22-19(23)27)14-9-7-6-8-10-14/h6-10,15H,3-5,11-13H2,1-2H3,(H2,21,26)(H,22,24,27)

HIDE SMILES / InChI

Molecular Formula	C20H27N3O6
Molecular Weight	405.4449
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://books.google.ru/books?id=leVCukUgNlsC&pg=PA258&lpg=PA258&dq=%22febarbamate&source=bl&ots=N9BpB_46QR&sig=ACfU3U0_n4LcW9NpMfYP8t5xURw5vOJAJg&hl=en&sa=X&ved=2ahUKEwidm_GI9bnhAhVAw8QBHbHEDZ4Q6AEwC3oECC0QAQ#v=onepage&q=%22febarbamate%22%20drug%20market&f=false | https://www.ncbi.nlm.nih.gov/pubmed/2664886

Febarbamate is a derivative of barbituric acid and carbamate, used for the treatment of generalized anxiety and alcohol withdrawal syndrome. The drug was marketed in Europe in the 1980s as a single agent or in combination with difebarbamate and phenobarbital, but it was later withdrawn from the market because of the potential risk of liver damage.

Approval Year

PubMed

Title	Date	PubMed
Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate.	1994 Dec	7699230
Severe hepatitis due to Atrium.	2001 Oct	11824432

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:29:19 GMT 2023` Edited by `admin` on `Fri Dec 15 16:29:19 GMT 2023`
Record UNII	5Z48ONN38P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FEBARBAMATE

Official Name

English

febarbamate [INN]

Common Name

English

FEBARBAMATE [MART.]

Common Name

English

Febarbamate [WHO-DD]

Common Name

English

1-(3-BUTOXY-2-HYDROXYPROPYL)-5-ETHYL-5-PHENYLBARBITURIC ACID CARBAMATE ESTER

Common Name

English

FEBARBAMATE [MI]

Common Name

English

GO-560

Code

English

Classification Tree Code System Code

WHO-VATC

QM03BA05