Diprobutine, or tripropylmethylamine, is a pharmacological agent with rather unusual anti-Parkinsonian activity. In experimental animals, it causes general arousal with stimulation of locomotor activity, antagonizes neuroleptic-induced catatonia and blocks nicotine-elicited convulsions. In vitro, diprobutine does not interact directly with either dopaminergic, noradrenergic, serotonergic or muscarinic brain binding sites. Diprobutine binds to the high affinity allosteric site for noncompetitive blockers on T. marmorata acetylcholine receptor. Diprobutine blocks the tonic crisis induced by nicotine. A pharmacological action of diprobutine as blocker of the ionic channel associated with brain nicotinic receptors.