Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C14H16N4O7S |
| Molecular Weight | 384.364 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)O[C@@H]1[C@@H](CO)O[C@H]([C@@H]1OC(C)=O)N2C(=O)SC3=C2N=C(N)N=C3
InChI
InChIKey=ZWELIJXAKMASLK-UGKPPGOTSA-N
InChI=1S/C14H16N4O7S/c1-5(20)23-9-7(4-19)25-12(10(9)24-6(2)21)18-11-8(26-14(18)22)3-16-13(15)17-11/h3,7,9-10,12,19H,4H2,1-2H3,(H2,15,16,17)/t7-,9-,10-,12-/m1/s1
| Molecular Formula | C14H16N4O7S |
| Molecular Weight | 384.364 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Masked oral prodrugs of toll-like receptor 7 agonists: a new approach for the treatment of infectious disease. | 2006-08 |
|
| Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection. | 2005-09 |
|
| Broad-spectrum activity of 8-chloro-7-deazaguanosine against RNA virus infections in mice and rats. | 1995-03 |
|
| Antiviral and immunomodulating inhibitors of experimentally-induced Punta Toro virus infections. | 1994-10 |
|
| Alkylpurines as immunopotentiating agents. Synthesis and antiviral activity of certain alkylguanines. | 1993-10-29 |
|
| Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system. | 1991-10 |
|
| Guanosine analogues. Synthesis of nucleosides of certain 3-substituted 6-aminopyrazolo[3,4-d]pyrimidin-4(5H)-ones as potential immunotherapeutic agents. | 1990-08 |
|
| Antiviral activity of the novel immune modulator 7-thia-8-oxoguanosine. | 1990-02 |
|
| Roles of interferon and natural killer cells in the antiviral activity of 7-thia-8-oxoguanosine against Semliki Forest virus infections in mice. | 1990-02 |
|
| Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents. | 1990-01 |
|
| Broad-spectrum in vivo antiviral activity of 7-thia-8-oxoguanosine, a novel immunopotentiating agent. | 1989-09 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Apr 01 16:29:57 GMT 2025
by
admin
on
Tue Apr 01 16:29:57 GMT 2025
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| Record UNII |
5UN5EF99CE
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| Record Status |
Validated (UNII)
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| Record Version |
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Created by
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847453-47-8
Created by
admin on Tue Apr 01 16:29:57 GMT 2025 , Edited by admin on Tue Apr 01 16:29:57 GMT 2025
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5UN5EF99CE
Created by
admin on Tue Apr 01 16:29:57 GMT 2025 , Edited by admin on Tue Apr 01 16:29:57 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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METABOLITE ACTIVE -> PRODRUG |
Class: Antiviral, Nucleoside; Mechanism of Action: Interferon alpha stimulant, Natural killer cell stimulant, Toll-like receptor 7 agonist; Highest Development Phases: Discontinued for Hepatitis B, Hepatitis C; Most Recent Events: 26 Jul 2007 Discontinued - Phase-I for Hepatitis C treatment in Europe (PO), 26 Jul 2007 Discontinued - Phase-I for Hepatitis C treatment in United Kingdom (PO), 26 Jul 2007 Discontinued - Preclinical for Hepatitis C treatment in USA (PO)
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
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