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Details

Stereochemistry ACHIRAL
Molecular Formula C10H22N4.H2O4S
Molecular Weight 296.387
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GUANETHIDINE MONOSULFATE

SMILES

OS(O)(=O)=O.NC(=N)NCCN1CCCCCCC1

InChI

InChIKey=YUFWAVFNITUSHI-UHFFFAOYSA-N
InChI=1S/C10H22N4.H2O4S/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h1-9H2,(H4,11,12,13);(H2,1,2,3,4)

HIDE SMILES / InChI

Molecular Formula H2O4S
Molecular Weight 98.078
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C10H22N4
Molecular Weight 198.3085
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Guanethidine belongs to the general class of medicines called antihypertensives. It was used to treat high blood pressure (hypertension). It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. It is taken up by norepinephrine transporters. It becomes concentrated in NE transmitter vesicles, replacing NE in these vesicles.

CNS Activity

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ISMELIN

AUC

ValueDoseCo-administeredAnalytePopulation
0.3 μg × h/mL
40 mg 1 times / day multiple, oral
GUANETHIDINE plasma
Homo sapiens
2.06 μg × h/mL
80 mg 1 times / day multiple, oral
GUANETHIDINE plasma
Homo sapiens
2.68 μg × h/mL
160 mg 1 times / day multiple, oral
GUANETHIDINE plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
1.5 day
160 mg 1 times / day multiple, oral
GUANETHIDINE plasma
Homo sapiens

Doses

AEs

OverviewOther

Other InhibitorOther SubstrateOther Inducer







Drug as perpetrator​

Drug as victim

Tox targets

PubMed

Sample Use Guides

In Vivo Use Guide
For high blood pressure: Adults—at first, 10 or 12.5 milligrams (mg) once a day. Then, your doctor may increase your dose to 25 to 50 mg once a day. Children: the dose is based on body weight and must be determined by your doctor. The usual dose is 200 micrograms (mcg) per kilogram (kg) (90.9 mcg per pound) of body weight a day.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
5UBY8Y002G
Record Status Validated (UNII)
Record Version