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Details

Stereochemistry RACEMIC
Molecular Formula C10H16O
Molecular Weight 152.2334
Optical Activity ( + / - )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CAMPHOR (SYNTHETIC)

SMILES

CC1(C)[C@@H]2CC[C@@]1(C)C(=O)C2

InChI

InChIKey=DSSYKIVIOFKYAU-XCBNKYQSSA-N
InChI=1S/C10H16O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7H,4-6H2,1-3H3/t7-,10+/m1/s1

HIDE SMILES / InChI

Molecular Formula C10H16O
Molecular Weight 152.2334
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Camphor is a bicyclic monoterpene ketone found widely in plants, especially cinnamomum camphora. Topically, camphor is used to relieve pain. It has been used to treat warts, cold sores, hemorrhoids, and osteoarthritis. It has also been applied topically as an analgesic and an antipruritic. It has been used as a counterirritant, and to increase local blood flow. Camphor has frequently been used topically to treat respiratory tract diseases involving mucous membrane inflammation. It is sometimes used topically to treat cardiac symptoms. Camphor is also used topically as an eardrop, and for treating minor burns. In inhalation therapy, camphor is used as an antitussive. Orally, camphor is used as an expectorant, antiflatulent, and for treating respiratory tract diseases. Today, most camphor is synthetic. It is approved by the FDA as a topical antitussive. Camphor is produced synthetically from the oil of turpentine. It has been used for centuries for its medicinal features, in religious rituals, and in cooking. It is no longer used as pesticide. In 1982, the US Food and Drug Administration restricted commercial products intended for medicinal use to contain <11% camphor.

CNS Activity

Curator's Comment: Camphor is highly lipid soluble and easily crosses the blood–brain barrier. Camphor is a CNS stimulant whose effects range from mild excitation to grand-mal convulsions or status epilepticus. These effects result from excitation of the cerebrum and lower structures of the CNS.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Camphor ointment

Approved Use

Camphor ointment is used for: Treating pain and itching associated with minor skin irritations. Camphor ointment is a topical analgesic. It works by temporarily relieving itching and pain.
Primary
CAMPHOR, EUCALYPTUS OIL AND MENTHOL - camphor, eucalyptus oil and menthol ointment CVS

Approved Use

Uses - on chest and throat, temporarily relieves cough due to common cold - On muscles and joints, temporarily relieves minor aches and pains
Palliative
Tetramex Spray

Approved Use

INDICATIONS AND USAGE: For temporary relief of minor aches and pains of the muscles and joints associated with simple backache, arthritis, strains, bruises and sprains.
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
41 ng/mL
374.4 mg single, topical
dose: 374.4 mg
route of administration: Topical
experiment type: SINGLE
co-administered: MENTHOL, UNSPECIFIED FORM
[NO STEREO] CAMPHOR, (-)-|[NO STEREO] CAMPHOR (SYNTHETIC)|[NO STEREO] CAMPHOR (NATURAL) plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
302 ng × h/mL
374.4 mg single, topical
dose: 374.4 mg
route of administration: Topical
experiment type: SINGLE
co-administered: MENTHOL, UNSPECIFIED FORM
[NO STEREO] CAMPHOR, (-)-|[NO STEREO] CAMPHOR (SYNTHETIC)|[NO STEREO] CAMPHOR (NATURAL) plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
6.5 h
374.4 mg single, topical
dose: 374.4 mg
route of administration: Topical
experiment type: SINGLE
co-administered: MENTHOL, UNSPECIFIED FORM
[NO STEREO] CAMPHOR, (-)-|[NO STEREO] CAMPHOR (SYNTHETIC)|[NO STEREO] CAMPHOR (NATURAL) plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
PubMed

PubMed

TitleDatePubMed
Lung cancer: therapeutic options for stage IV and recurrent NSCLC.
2001
Assaying drug-induced apoptosis.
2001
Analysis of cleavage complexes using reactive inhibitor derivatives.
2001
Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma.
2001 Apr 10
DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells.
2001 Apr 13
Prevention of irinotecan (CPT-11)-induced diarrhea by oral alkalization combined with control of defecation in cancer patients.
2001 Apr 15
Adjuvant therapy of colon cancer.
2001 Feb
Different susceptibilities of postmitotic checkpoint-proficient and -deficient Balb / 3T3 cells to ICRF-193, a catalytic inhibitor of DNA topoisomerase II.
2001 Feb
High-Performance liquid chromatographic analysis of lactone and hydroxy acid of new antitumor drug, DX-8951 (exatecan), in mouse plasma.
2001 Feb
Ternary combination of irinotecan, fluorouracil-folinic acid and oxaliplatin: results on human colon cancer cell lines.
2001 Feb
Apoptotic response of HL-60 human leukemia cells to the antitumor drug NB-506, a glycosylated indolocarbazole inhibitor of topoisomerase 1.
2001 Feb 1
Irinotecan and chronomodulated infusion of 5-fluorouracil and folinic acid in the treatment of patients with advanced colorectal carcinoma: a phase I study.
2001 Feb 15
Phase I trial of the combination of irinotecan, paclitaxel, and carboplatin in patients with advanced non-small-cell lung cancer.
2001 Feb 15
The homocamptothecin BN 80915 is a highly potent orally active topoisomerase I poison.
2001 Jan
Current status of irinotecan in lung cancer.
2001 Jan
The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux.
2001 Jan 15
Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor.
2001 Jan 15
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer.
2001 Jan 25
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer.
2001 Jan 25
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer.
2001 Jan 25
Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons.
2001 Mar
Topoisomerase I targeting agents in small-cell lung cancer.
2001 Mar
Phase I and pharmacokinetic study of exatecan mesylate (DX-8951f): a novel camptothecin analog.
2001 Mar 1
Potentiation of antitumor activity of irinotecan by chemically modified oligonucleotides.
2001 May
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Subcutaneous: The dose of subcutaneously injected camphor required to produce convulsions in mice was 600 mg/kg http://www.sciencedirect.com/science/article/pii/B9780443062414000102
Dosing: Adult Cough: Inhalation: Inhale via vaporizer up to 3 times per day. Pain: Topical cream: Apply to affected area up to 4 times per day for 2 weeks. For maximum benefit, use daily for at least 2 weeks and continue to use daily as needed thereafter. Pruritus/Pain: Topical gel: Apply to affected area up to 3 to 4 times per day.
Route of Administration: Topical
1 mM camphor partially inhibited the AITC (20 uM)-induced hTRPA1 current in HEK293T cells expressing hTRPA1.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:48:32 GMT 2025
Edited
by admin
on Mon Mar 31 18:48:32 GMT 2025
Record UNII
5TJD82A1ET
Record Status Validated (UNII)
Record Version
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Name Type Language
CAMPHOR, RACEMIC
EP  
Preferred Name English
CAMPHOR (SYNTHETIC)
Common Name English
CAMPHOR, DL-
Common Name English
2-BORNANONE
Systematic Name English
DL-CAMPHOR
Common Name English
(±)-CAMPHOR
Systematic Name English
CAMPHOR, (±)-
Systematic Name English
1,7,7-TRIMETHYLBICYCLO(2.2.1)HEPTAN-2-ONE
Systematic Name English
FEMA NO. 4513
Code English
(1RS,4RS)-1,7,7-TRIMETHYLBICYCLO(2.2.1)HEPTAN-2-ONE
Systematic Name English
BICYCLO(2.2.1)HEPTANE-2-ONE, 1,7,7-TRIMETHYL-
Systematic Name English
GUM CAMPHOR
Common Name English
CAMPHOR, RACEMIC [EP MONOGRAPH]
Common Name English
2-CAMPHANONE
Systematic Name English
DL-CAMPHOR [JAN]
Common Name English
Camphor [WHO-DD]
Common Name English
SYNTHETIC CAMPHOR
Common Name English
CAMPHOR [MI]
Common Name English
CAMPHOR [HSDB]
Common Name English
Code System Code Type Description
DAILYMED
5TJD82A1ET
Created by admin on Mon Mar 31 18:48:32 GMT 2025 , Edited by admin on Mon Mar 31 18:48:32 GMT 2025
PRIMARY
DRUG BANK
DB01744
Created by admin on Mon Mar 31 18:48:32 GMT 2025 , Edited by admin on Mon Mar 31 18:48:32 GMT 2025
PRIMARY
ECHA (EC/EINECS)
200-945-0
Created by admin on Mon Mar 31 18:48:32 GMT 2025 , Edited by admin on Mon Mar 31 18:48:32 GMT 2025
PRIMARY
SMS_ID
100000090737
Created by admin on Mon Mar 31 18:48:32 GMT 2025 , Edited by admin on Mon Mar 31 18:48:32 GMT 2025
PRIMARY
CAS
76-22-2
Created by admin on Mon Mar 31 18:48:32 GMT 2025 , Edited by admin on Mon Mar 31 18:48:32 GMT 2025
PRIMARY
HSDB
37
Created by admin on Mon Mar 31 18:48:32 GMT 2025 , Edited by admin on Mon Mar 31 18:48:32 GMT 2025
PRIMARY
EPA CompTox
DTXSID5030955
Created by admin on Mon Mar 31 18:48:32 GMT 2025 , Edited by admin on Mon Mar 31 18:48:32 GMT 2025
PRIMARY
RXCUI
1371994
Created by admin on Mon Mar 31 18:48:32 GMT 2025 , Edited by admin on Mon Mar 31 18:48:32 GMT 2025
PRIMARY RxNorm
ChEMBL
CHEMBL504760
Created by admin on Mon Mar 31 18:48:32 GMT 2025 , Edited by admin on Mon Mar 31 18:48:32 GMT 2025
PRIMARY
JECFA MONOGRAPH
2172
Created by admin on Mon Mar 31 18:48:32 GMT 2025 , Edited by admin on Mon Mar 31 18:48:32 GMT 2025
PRIMARY
EVMPD
SUB11780MIG
Created by admin on Mon Mar 31 18:48:32 GMT 2025 , Edited by admin on Mon Mar 31 18:48:32 GMT 2025
PRIMARY
CHEBI
36773
Created by admin on Mon Mar 31 18:48:32 GMT 2025 , Edited by admin on Mon Mar 31 18:48:32 GMT 2025
PRIMARY
NCI_THESAURUS
C28136
Created by admin on Mon Mar 31 18:48:32 GMT 2025 , Edited by admin on Mon Mar 31 18:48:32 GMT 2025
PRIMARY
FDA UNII
5TJD82A1ET
Created by admin on Mon Mar 31 18:48:32 GMT 2025 , Edited by admin on Mon Mar 31 18:48:32 GMT 2025
PRIMARY
MERCK INDEX
m3004
Created by admin on Mon Mar 31 18:48:32 GMT 2025 , Edited by admin on Mon Mar 31 18:48:32 GMT 2025
PRIMARY Merck Index
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
PARENT -> CONSTITUENT MAY BE PRESENT
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PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (GC)
USP
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ACTIVE MOIETY