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Details

Stereochemistry ACHIRAL
Molecular Formula C21H21NO2.C4H4O4
Molecular Weight 435.4691
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 2
Charge 0

SHOW SMILES / InChI
Structure of OXETORONE FUMARATE

SMILES

OC(=O)\C=C\C(O)=O.CN(C)CCC=C1C2=C(COC3=C1C=CC=C3)C4=C(O2)C=CC=C4

InChI

InChIKey=DQHRYCOJUKGIDH-WLHGVMLRSA-N
InChI=1S/C21H21NO2.C4H4O4/c1-22(2)13-7-10-17-15-8-3-5-11-19(15)23-14-18-16-9-4-6-12-20(16)24-21(17)18;5-3(6)1-2-4(7)8/h3-6,8-12H,7,13-14H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

HIDE SMILES / InChI

Molecular Formula C21H21NO2
Molecular Weight 319.3969
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Oxetorone is an antimigraine drug used for the disease-modifying treatment of migraines and marketed in several European countries. It works by non-selective inhibition of serotonin receptors and antihistamine agent. The therapeutic effects of oxetorone are primarily linked to antiserotonergic and also antihistamine and anti-adrenergic properties. Antidopaminergic properties are also suspected because hyperprolactinemia and extrapyramidal reactions have been observed. Adverse effects are: hypertonia, drowsiness at the start of treatment, diarrhoea and lymphocytic colitis. Acute intoxications by oxetorone, although uncommon, are potentially severe poisonings.

Approval Year

Patents

Sample Use Guides

1 to 2 tablets (60 to 120 mg) a day
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:25:21 UTC 2023
Edited
by admin
on Fri Dec 15 15:25:21 UTC 2023
Record UNII
5SYZ8I05SH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OXETORONE FUMARATE
MART.   MI   USAN   WHO-DD  
USAN  
Official Name English
Oxetorone fumarate [WHO-DD]
Common Name English
OXETORONE FUMARATE [MART.]
Common Name English
OXETORONE FUMARATE [MI]
Common Name English
OXETORONE FUMARATE [USAN]
Common Name English
L-6257
Code English
Classification Tree Code System Code
NCI_THESAURUS C66885
Created by admin on Fri Dec 15 15:25:21 UTC 2023 , Edited by admin on Fri Dec 15 15:25:21 UTC 2023
Code System Code Type Description
MESH
C011962
Created by admin on Fri Dec 15 15:25:21 UTC 2023 , Edited by admin on Fri Dec 15 15:25:21 UTC 2023
PRIMARY
NCI_THESAURUS
C77264
Created by admin on Fri Dec 15 15:25:21 UTC 2023 , Edited by admin on Fri Dec 15 15:25:21 UTC 2023
PRIMARY
FDA UNII
5SYZ8I05SH
Created by admin on Fri Dec 15 15:25:21 UTC 2023 , Edited by admin on Fri Dec 15 15:25:21 UTC 2023
PRIMARY
CAS
34522-46-8
Created by admin on Fri Dec 15 15:25:21 UTC 2023 , Edited by admin on Fri Dec 15 15:25:21 UTC 2023
PRIMARY
RXCUI
54243
Created by admin on Fri Dec 15 15:25:21 UTC 2023 , Edited by admin on Fri Dec 15 15:25:21 UTC 2023
PRIMARY RxNorm
PUBCHEM
76971374
Created by admin on Fri Dec 15 15:25:21 UTC 2023 , Edited by admin on Fri Dec 15 15:25:21 UTC 2023
PRIMARY
MERCK INDEX
m8303
Created by admin on Fri Dec 15 15:25:21 UTC 2023 , Edited by admin on Fri Dec 15 15:25:21 UTC 2023
PRIMARY Merck Index
SMS_ID
100000089627
Created by admin on Fri Dec 15 15:25:21 UTC 2023 , Edited by admin on Fri Dec 15 15:25:21 UTC 2023
PRIMARY
ChEMBL
CHEMBL2111020
Created by admin on Fri Dec 15 15:25:21 UTC 2023 , Edited by admin on Fri Dec 15 15:25:21 UTC 2023
PRIMARY
EVMPD
SUB03568MIG
Created by admin on Fri Dec 15 15:25:21 UTC 2023 , Edited by admin on Fri Dec 15 15:25:21 UTC 2023
PRIMARY
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PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY