JNJ-39758979

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C11H19N5
Molecular Weight	221.3021
Optical Activity	( - )
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)C1=CC(=NC(N)=N1)N2CC[C@@H](N)C2

InChI

InChIKey=COOGVHJHSCBOQT-MRVPVSSYSA-N

InChI=1S/C11H19N5/c1-7(2)9-5-10(15-11(13)14-9)16-4-3-8(12)6-16/h5,7-8H,3-4,6,12H2,1-2H3,(H2,13,14,15)/t8-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C11H19N5
Molecular Weight	221.3021
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/2001967 | https://www.ncbi.nlm.nih.gov/pubmed/24495018 | https://clinicaltrials.gov/ct2/show/record/NCT01497119

JNJ-39758979 is a histamine H4 receptor antagonist which clinical development for asthma and atopic dermatitis was halted during phase II because of the observation of idiosyncratic drug-induced agranulocytosis in two subjects.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H4 receptor 20 Target ID: CHEMBL3759 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24495018	Antagonist 2778		12.5 nM [Ki]

PubMed

Title	Date	PubMed
Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.	2014 Mar 27	24495018
International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.	2015 Jul	26084539

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:42:19 GMT 2023` Edited by `admin` on `Sat Dec 16 09:42:19 GMT 2023`
Record UNII	5RV7T5BNMG
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

JNJ-39758979

Code

English

JNJ 39758979 [WHO-DD]

Common Name

English

2-PYRIMIDINAMINE, 4-((3R)-3-AMINO-1-PYRROLIDINYL)-6-(1-METHYLETHYL)-

Systematic Name

English

JNJ-39758979, (-)-

Code

English

JNJ39758979

Code

English

Code System Code Type Description

FDA UNII

5RV7T5BNMG

Created by admin on Sat Dec 16 09:42:19 GMT 2023 , Edited by admin on Sat Dec 16 09:42:19 GMT 2023

PRIMARY

PUBCHEM

24994634

Created by admin on Sat Dec 16 09:42:19 GMT 2023 , Edited by admin on Sat Dec 16 09:42:19 GMT 2023

PRIMARY

CAS

1046447-90-8

Created by admin on Sat Dec 16 09:42:19 GMT 2023 , Edited by admin on Sat Dec 16 09:42:19 GMT 2023

PRIMARY

Related Record Type Details


					539B0275OU

HISTAMINE H4 RECEPTOR

TARGET -> INHIBITOR

Amount:


					W00RQD3LO2

JNJ-39758979 DIHYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					5RV7T5BNMG

JNJ-39758979

ACTIVE MOIETY

Amount:

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/mesh/2001967 | https://www.ncbi.nlm.nih.gov/pubmed/24495018 | https://clinicaltrials.gov/ct2/show/record/NCT01497119

Originator

Approval Year

Targets

PubMed

Patents

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/2001967 | https://www.ncbi.nlm.nih.gov/pubmed/24495018 | https://clinicaltrials.gov/ct2/show/record/NCT01497119