LANATOSIDE C

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C49H76O20
Molecular Weight	985.1157
Optical Activity	UNSPECIFIED
Defined Stereocenters	26 / 26
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12CC[C@]3([H])[C@]([H])(C[C@@H](O)[C@]4(C)[C@H](CC[C@]34O)C5=CC(=O)OC5)[C@@]1(C)CC[C@@H](C2)O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O[C@H]8C[C@H](OC(C)=O)[C@H](O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O)[C@@H](C)O8)[C@@H](C)O7)[C@@H](C)O6

InChI

InChIKey=JAYAGJDXJIDEKI-PTGWOZRBSA-N

InChI=1S/C49H76O20/c1-21-43(67-38-17-32(53)44(22(2)62-38)68-39-18-33(64-24(4)51)45(23(3)63-39)69-46-42(58)41(57)40(56)34(19-50)66-46)31(52)16-37(61-21)65-27-9-11-47(5)26(14-27)7-8-29-30(47)15-35(54)48(6)28(10-12-49(29,48)59)25-13-36(55)60-20-25/h13,21-23,26-35,37-46,50,52-54,56-59H,7-12,14-20H2,1-6H3/t21-,22-,23-,26-,27+,28-,29-,30+,31+,32+,33+,34-,35-,37+,38+,39+,40-,41+,42-,43-,44-,45-,46+,47+,48+,49+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C49H76O20
Molecular Weight	985.1157
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	26 / 26
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: doi:10.1021/np50084a007

Lanatoside C (or isolanid) is a cardiac glycoside, a type of drug that can be used in the treatment of heart disease. Digitalis lanata is a significant medicinal plant as a source of this compound. Lanatoside C is marketed in a number of countries and it’s also available in generic form. It can be transformed into digoxin by deglucolysation.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Congestive heart failure 54 Sources: http://www.ncbi.nlm.nih.gov/pubmed/6492562	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Effect of a single dose of lanatoside C on the left heart ventricle in patients with primary congestive cardiomyopathy].	1984	6492562

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:53:44 GMT 2023` Edited by `admin` on `Sat Dec 16 16:53:44 GMT 2023`
Record UNII	5RR3JFZ771
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LANATOSIDE C

Official Name

English

LANATIGEN C

Brand Name

English

CETOSANOL

Brand Name

English

LANATOSIDE C [MART.]

Common Name

English

CELADIGAL

Brand Name

English

Lanatoside c [WHO-DD]

Common Name

English

CEDILANID

Brand Name

English

LANATOSIDE C [MI]

Common Name

English

lanatoside c [INN]

Common Name

English

NSC-119991

Code

English

ISOLANIDE

Brand Name

English

LANIMERCK

Brand Name

English

DIGOXIN IMPURITY H [EP IMPURITY]

Common Name

English

NSC-7533

Code

English

ISOLANID

Brand Name

English

3.BETA.-((.BETA.-D-GLUCOPYRANOSYL-(1->4)-3-O-ACETYL-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL)OXY)-12.BETA.,14-DIHYDROXY-5.BETA.-CARD-20(22)-ENOLIDE

Systematic Name

English

LANATOSIDE C [JAN]

Common Name

English

ALLOCOR

Brand Name

English

DIGILANOGEN C

Brand Name

English

LANATOSIDE C JP 17 [JAN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QC01AA06