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Details

Stereochemistry ACHIRAL
Molecular Formula C16H19N3S
Molecular Weight 285.407
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROTHIPENDYL

SMILES

CN(C)CCCN1C2=C(SC3=C1N=CC=C3)C=CC=C2

InChI

InChIKey=JTTAUPUMOLRVRA-UHFFFAOYSA-N
InChI=1S/C16H19N3S/c1-18(2)11-6-12-19-13-7-3-4-8-14(13)20-15-9-5-10-17-16(15)19/h3-5,7-10H,6,11-12H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C16H19N3S
Molecular Weight 285.407
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

PROTHIPENDYL is a neuroleptic azaphenothiazine used to treat anxiety and agitation in psychotic syndromes. It also shows strong antihistamine and anti-emetic actions.

Approval Year

Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
18 ng/mL
40 mg single, oral
dose: 40 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PROTHIPENDYL serum
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
42.6 ng/mL
80 mg single, oral
dose: 80 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PROTHIPENDYL serum
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2.5 h
unknown, oral
PROTHIPENDYL unknown
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
1280 mg 1 times / day multiple, oral
Studied dose
Dose: 1280 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1280 mg, 1 times / day
Sources:
unhealthy, 20 years (range: 16-31 years)
n = 10
Health Status: unhealthy
Condition: long-standing behaviour disorders
Age Group: 20 years (range: 16-31 years)
Sex: M
Population Size: 10
Sources:
960 mg 1 times / day multiple, oral
Studied dose
Dose: 960 mg, 1 times / day
Route: oral
Route: multiple
Dose: 960 mg, 1 times / day
Sources:
unhealthy, 26 years (range: 14-42 years)
n = 10
Health Status: unhealthy
Condition: long-standing behaviour disorders
Age Group: 26 years (range: 14-42 years)
Sex: F
Population Size: 10
Sources:
4 g single, oral
Overdose
Dose: 4 g
Route: oral
Route: single
Dose: 4 g
Sources:
unknown
Health Status: unknown
Sources:
Other AEs: Adverse event...
Other AEs:
Adverse event (grade 5)
Sources:
AEs

AEs

AESignificanceDosePopulation
Adverse event grade 5
4 g single, oral
Overdose
Dose: 4 g
Route: oral
Route: single
Dose: 4 g
Sources:
unknown
Health Status: unknown
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG



OverviewOther

Other InhibitorOther SubstrateOther Inducer


Drug as victim
PubMed

PubMed

TitleDatePubMed
Different fatal toxicity of neuroleptics identified by autopsy.
2001 Apr
Application of ammonium peroxidisulfate and metavanadate for spectrophotometric determination of prothipendyl hydrochloride.
2001 Mar-Apr
Fatal accident caused by isoflurane abuse.
2002 Dec
Simultaneous prescribing of atypical antipsychotics, conventional antipsychotics and anticholinergics-a European study.
2007 Jun
Increased D-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study.
2009 Dec
Psychotropic medication use among nursing home residents in Austria: a cross-sectional study.
2009 May 21
A double-blind, randomized, parallel group study to compare the efficacy, safety and tolerability of slow-release oral morphine versus methadone in opioid-dependent in-patients willing to undergo detoxification.
2009 Sep
Research on antipsychotics in India.
2010 Jan
The impact of perfectionism and anxiety traits on action monitoring in major depressive disorder.
2010 Jul
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:28:10 UTC 2023
Edited
by admin
on Fri Dec 15 15:28:10 UTC 2023
Record UNII
5O6VWA87VA
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PROTHIPENDYL
INN   MI   WHO-DD  
INN  
Official Name English
PROTHIPENDYL [MI]
Common Name English
prothipendyl [INN]
Common Name English
Prothipendyl [WHO-DD]
Common Name English
N,N-DIMETHYL-10H-PYRIDO(3,2-B)(1,4)BENZOTHIAZINE-10-PROPANAMINE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29710
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
WHO-VATC QN05AX07
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
WHO-ATC N05AX07
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
Code System Code Type Description
WIKIPEDIA
PROTHIPENDYL
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
PRIMARY
MESH
C069248
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
PRIMARY
FDA UNII
5O6VWA87VA
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
PRIMARY
SMS_ID
100000080835
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
PRIMARY
ChEMBL
CHEMBL2111030
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
PRIMARY
CAS
303-69-5
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
PRIMARY
INN
691
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
PRIMARY
RXCUI
55244
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
PRIMARY RxNorm
DRUG BANK
DB12958
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
PRIMARY
NCI_THESAURUS
C84124
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
PRIMARY
PUBCHEM
14670
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
PRIMARY
EVMPD
SUB10138MIG
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
PRIMARY
EPA CompTox
DTXSID50184389
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
PRIMARY
MERCK INDEX
m9268
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
PRIMARY Merck Index
DRUG CENTRAL
2315
Created by admin on Fri Dec 15 15:28:10 UTC 2023 , Edited by admin on Fri Dec 15 15:28:10 UTC 2023
PRIMARY
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