PROTHIPENDYL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H19N3S
Molecular Weight	285.407
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CN(C)CCCN1C2=C(SC3=C1N=CC=C3)C=CC=C2

InChI

InChIKey=JTTAUPUMOLRVRA-UHFFFAOYSA-N

InChI=1S/C16H19N3S/c1-18(2)11-6-12-19-13-7-3-4-8-14(13)20-15-9-5-10-17-16(15)19/h3-5,7-10H,6,11-12H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C16H19N3S
Molecular Weight	285.407
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

PROTHIPENDYL is a neuroleptic azaphenothiazine used to treat anxiety and agitation in psychotic syndromes. It also shows strong antihistamine and anti-emetic actions.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine D1 receptor 101	Antagonist 2,778
Dopamine D2 receptor 297	Antagonist 2,778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Tranquilizer 4	Primary		Approved 8,429	Unknown

C_max

Value	Dose	Co-administered	Analyte	Population
18 ng/mL	40 mg single, oral		PROTHIPENDYL serum	Homo sapiens
42.6 ng/mL	80 mg single, oral		PROTHIPENDYL serum	Homo sapiens

T_1/2

Value	Dose	Co-administered	Analyte	Population
2.5 h	unknown, oral		PROTHIPENDYL unknown	Homo sapiens

Doses

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Dose	Population	Adverse events
1280 mg 1 times / day multiple, oral Studied dose	unhealthy, 20 years (range: 16-31 years) n = 10
960 mg 1 times / day multiple, oral Studied dose	unhealthy, 26 years (range: 14-42 years) n = 10
4 g single, oral Overdose	unknown	Other AEs: Adverse event...

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AEs

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AE	Significance	Dose	Population
Adverse event	grade 5	4 g single, oral Overdose	unknown

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Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1,737	substrate 1,037	substrate 1,217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
	CYP1A2 1,054 CYP2C19 991

Drug as victim

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Target	Modality	Activity
CYP2C9 1,037	substrate 3,367	likely
CYP1A2 1,054	substrate 3,367	major
CYP2C19 991	substrate 3,367	major
CYP2D6 1,217	substrate 3,367	minor
CYP3A4 1,737	substrate 3,367	minor

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Sourcing

Sourcing

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Vendor/Aggregator	ID	URL
001 Chemical	DY547352	https://www.001chemical.com/chem/303-69-5
ABI Chem	AC1L24BL
BOC Sciences	303-69-5
Chemieliva Pharmaceutical Co., Ltd	PBCM1267030
Compound Cloud	14669

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PubMed

PubMed

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Title	Date	PubMed
A double-blind, randomized, parallel group study to compare the efficacy, safety and tolerability of slow-release oral morphine versus methadone in opioid-dependent in-patients willing to undergo detoxification.	2009 Sep	19686525
Research on antipsychotics in India.	2010 Jan	21836703

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Substance Class	Chemical
Record UNII	5O6VWA87VA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROTHIPENDYL

Official Name

English

PROTHIPENDYL [MI]

Common Name

English

prothipendyl [INN]

Common Name

English

Prothipendyl [WHO-DD]

Common Name

English

N,N-DIMETHYL-10H-PYRIDO(3,2-B)(1,4)BENZOTHIAZINE-10-PROPANAMINE

Systematic Name

English

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Classification Tree

Code System

Code

Agent Affecting Nervous System

NCI_THESAURUS

C29710

Other antipsychotics

WHO-VATC

QN05AX07

Other antipsychotics

WHO-ATC

N05AX07

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Code System

Code

Type

Description

WIKIPEDIA

PROTHIPENDYL

PRIMARY

MESH

C069248

PRIMARY

FDA UNII

5O6VWA87VA

PRIMARY

SMS_ID

100000080835

PRIMARY

ChEMBL

CHEMBL2111030

PRIMARY

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Related Record

Type

Details


					7610629RVH

PROTHIPENDYL HYDROCHLORIDE

SALT/SOLVATE -> PARENT

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Related Record

Type

Details


					5O6VWA87VA

PROTHIPENDYL

ACTIVE MOIETY

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SMILES

InChI

CNS Activity

Approval Year

Targets

Conditions

Cmax

T1/2

Doses

AEs

Overview

OverviewOther

Drug as victim

Sourcing

PubMed

C_max

T_1/2